Abstract
Introduction: To elucidate how obstetric conditions are associated with atypical placental weight ratios (PWR)s in infants born: (a) >= 37 weeks gestation; (b) at >= 33 but
Methods: The study included all in-hospital singleton births in London, Ontario between June 1, 2006 and March 31, 2011. PWR was assessed as 90th percentile by gestational age-specific local population standards. Multivariable analysis was carried out using multinomial logistic regression with blockwise variable entry in order of temporality.
Results: Baseline factors and maternal obstetric conditions associated with PWR 90th percentile were: underweight, overweight and obese BMIs, smoking, preeclampsia, placenta previa, and placental abruption. In particular, indicators of hypoxia and altered placental function were generally associated with elevated PWR at all gestations.
Discussion: An association between obstetric conditions associated with fetal hypoxia and PWR >90th percentile was illustrated.
Conclusions: The multivariable findings suggest that the PWR is similarly increased regardless of the etiology of the hypoxia. (C) 2014 Elsevier Ltd. All rights reserved.
| Original language | English |
|---|---|
| Pages (from-to) | 582-586 |
| Number of pages | 5 |
| Journal | Placenta |
| Volume | 35 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Aug 2014 |
Keywords
- fetal growth
- placental growth
- placental weight ratio
- hypoxia
- birth-weight
- gestational-age
- fetal-growth
- cardiovascular-disease
- maternal smoking
- 1st trimester
- adult life
- oxygen
- preeclampsia
- trophoblast
Cite this
Obstetric conditions and the placental weight ratio. / Macdonald, E M; Natale, R; Regnault, T R H; Koval, J J; Campbell, M K.
In: Placenta, Vol. 35, No. 8, 08.2014, p. 582-586.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Obstetric conditions and the placental weight ratio
AU - Macdonald, E M
AU - Natale, R
AU - Regnault, T R H
AU - Koval, J J
AU - Campbell, M K
PY - 2014/8
Y1 - 2014/8
N2 - Introduction: To elucidate how obstetric conditions are associated with atypical placental weight ratios (PWR)s in infants born: (a) >= 37 weeks gestation; (b) at >= 33 but Methods: The study included all in-hospital singleton births in London, Ontario between June 1, 2006 and March 31, 2011. PWR was assessed as 90th percentile by gestational age-specific local population standards. Multivariable analysis was carried out using multinomial logistic regression with blockwise variable entry in order of temporality. Results: Baseline factors and maternal obstetric conditions associated with PWR 90th percentile were: underweight, overweight and obese BMIs, smoking, preeclampsia, placenta previa, and placental abruption. In particular, indicators of hypoxia and altered placental function were generally associated with elevated PWR at all gestations. Discussion: An association between obstetric conditions associated with fetal hypoxia and PWR >90th percentile was illustrated. Conclusions: The multivariable findings suggest that the PWR is similarly increased regardless of the etiology of the hypoxia. (C) 2014 Elsevier Ltd. All rights reserved.
AB - Introduction: To elucidate how obstetric conditions are associated with atypical placental weight ratios (PWR)s in infants born: (a) >= 37 weeks gestation; (b) at >= 33 but Methods: The study included all in-hospital singleton births in London, Ontario between June 1, 2006 and March 31, 2011. PWR was assessed as 90th percentile by gestational age-specific local population standards. Multivariable analysis was carried out using multinomial logistic regression with blockwise variable entry in order of temporality. Results: Baseline factors and maternal obstetric conditions associated with PWR 90th percentile were: underweight, overweight and obese BMIs, smoking, preeclampsia, placenta previa, and placental abruption. In particular, indicators of hypoxia and altered placental function were generally associated with elevated PWR at all gestations. Discussion: An association between obstetric conditions associated with fetal hypoxia and PWR >90th percentile was illustrated. Conclusions: The multivariable findings suggest that the PWR is similarly increased regardless of the etiology of the hypoxia. (C) 2014 Elsevier Ltd. All rights reserved.
KW - fetal growth
KW - placental growth
KW - placental weight ratio
KW - hypoxia
KW - birth-weight
KW - gestational-age
KW - fetal-growth
KW - cardiovascular-disease
KW - maternal smoking
KW - 1st trimester
KW - adult life
KW - oxygen
KW - preeclampsia
KW - trophoblast
U2 - 10.1016/j.placenta.2014.04.019
DO - 10.1016/j.placenta.2014.04.019
M3 - Article
VL - 35
SP - 582
EP - 586
JO - Placenta
JF - Placenta
SN - 0143-4004
IS - 8
ER -