Obstetric conditions and the placental weight ratio

E M Macdonald, R Natale, T R H Regnault, J J Koval, M K Campbell

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)


Introduction: To elucidate how obstetric conditions are associated with atypical placental weight ratios (PWR)s in infants born: (a) >= 37 weeks gestation; (b) at >= 33 but

Methods: The study included all in-hospital singleton births in London, Ontario between June 1, 2006 and March 31, 2011. PWR was assessed as 90th percentile by gestational age-specific local population standards. Multivariable analysis was carried out using multinomial logistic regression with blockwise variable entry in order of temporality.

Results: Baseline factors and maternal obstetric conditions associated with PWR 90th percentile were: underweight, overweight and obese BMIs, smoking, preeclampsia, placenta previa, and placental abruption. In particular, indicators of hypoxia and altered placental function were generally associated with elevated PWR at all gestations.

Discussion: An association between obstetric conditions associated with fetal hypoxia and PWR >90th percentile was illustrated.

Conclusions: The multivariable findings suggest that the PWR is similarly increased regardless of the etiology of the hypoxia. (C) 2014 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)582-586
Number of pages5
Issue number8
Publication statusPublished - Aug 2014


  • fetal growth
  • placental growth
  • placental weight ratio
  • hypoxia
  • birth-weight
  • gestational-age
  • fetal-growth
  • cardiovascular-disease
  • maternal smoking
  • 1st trimester
  • adult life
  • oxygen
  • preeclampsia
  • trophoblast


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