Introduction: To elucidate how obstetric conditions are associated with atypical placental weight ratios (PWR)s in infants born: (a) >= 37 weeks gestation; (b) at >= 33 but
Methods: The study included all in-hospital singleton births in London, Ontario between June 1, 2006 and March 31, 2011. PWR was assessed as 90th percentile by gestational age-specific local population standards. Multivariable analysis was carried out using multinomial logistic regression with blockwise variable entry in order of temporality.
Results: Baseline factors and maternal obstetric conditions associated with PWR 90th percentile were: underweight, overweight and obese BMIs, smoking, preeclampsia, placenta previa, and placental abruption. In particular, indicators of hypoxia and altered placental function were generally associated with elevated PWR at all gestations.
Discussion: An association between obstetric conditions associated with fetal hypoxia and PWR >90th percentile was illustrated.
Conclusions: The multivariable findings suggest that the PWR is similarly increased regardless of the etiology of the hypoxia. (C) 2014 Elsevier Ltd. All rights reserved.
- fetal growth
- placental growth
- placental weight ratio
- maternal smoking
- 1st trimester
- adult life