Obstetric outcome in women with subfertility

F. Thompson, Smruta Shanbhag, Alexander Allan Templeton, Siladitya Bhattacharya

Research output: Contribution to journalArticle

127 Citations (Scopus)

Abstract

Background It has been suggested that a history of subfertility is associated with increased obstetric and perinatal risks. It is unclear if the cause is inherent characteristics in the women or the fertility treatment.

Objectives To compare the obstetric and perinatal risks of singleton pregnancies in women with a history of subfertility in comparison with the general population.

Design Population cohort.

Setting Aberdeen, Scotland.

Population Cases were women attending the Fertility Clinic between 1989 and 1999 who subsequently went on to have singleton pregnancies. Controls included the general population of women who delivered singletons over the same period.

Methods We performed a retrospective cohort study to investigate the obstetric outcome of singleton pregnancies in women with subfertility. The general population of women who delivered singletons over the same period served as controls.

Main outcome measures Obstetric and perinatal complications in singleton pregnancies.

Results Maternity records were available for a total of 1437 subfertile women and 21,688 controls. Subfertile women were older [mean (SD) age: 31 (4.7) years vs 27 (5.4) years, P < 0.01] and more likely to be primiparous (70%vs 65%, P < 0.001). After adjusting for age and parity, subfertile women were at increased risk of pre-eclampsia (OR 1.9, 95% CI 1.5-2.5), placenta praevia (OR 3.9, 95% CI 2.2-7.0) and placental abruption (OR 1.8, 95% CI 1.1-3.0), and more likely to undergo induction of labour (OR 1.5, 95% CI 1.3-1.6), caesarean section (OR 2.1, 95% CI 1.8-2.4) and instrumental delivery (OR 2.2, 95% CI 1.8-2.6), and deliver low birthweight (OR 1.4, 95% CI 1.3-1.7) and preterm (OR 1.7, 95% CI 1.2-2.2) infants. There were no differences between treatment-related and treatment-independent pregnancies.

Conclusion Subfertile women are at higher risk of obstetric complications, which persist after adjusting for age and parity.

Original languageEnglish
Pages (from-to)632-637
Number of pages5
JournalBJOG-An International Journal of Obstetrics and Gynaecology
Volume112
DOIs
Publication statusPublished - 2005

Keywords

  • BIRTH-WEIGHT
  • UNEXPLAINED INFERTILITY
  • PREGNANCIES
  • COMPLICATIONS
  • DELIVERY
  • SERVICES
  • HISTORY
  • COUPLES

Cite this

Obstetric outcome in women with subfertility. / Thompson, F.; Shanbhag, Smruta; Templeton, Alexander Allan; Bhattacharya, Siladitya.

In: BJOG-An International Journal of Obstetrics and Gynaecology, Vol. 112, 2005, p. 632-637.

Research output: Contribution to journalArticle

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title = "Obstetric outcome in women with subfertility",
abstract = "Background It has been suggested that a history of subfertility is associated with increased obstetric and perinatal risks. It is unclear if the cause is inherent characteristics in the women or the fertility treatment.Objectives To compare the obstetric and perinatal risks of singleton pregnancies in women with a history of subfertility in comparison with the general population.Design Population cohort.Setting Aberdeen, Scotland.Population Cases were women attending the Fertility Clinic between 1989 and 1999 who subsequently went on to have singleton pregnancies. Controls included the general population of women who delivered singletons over the same period.Methods We performed a retrospective cohort study to investigate the obstetric outcome of singleton pregnancies in women with subfertility. The general population of women who delivered singletons over the same period served as controls.Main outcome measures Obstetric and perinatal complications in singleton pregnancies.Results Maternity records were available for a total of 1437 subfertile women and 21,688 controls. Subfertile women were older [mean (SD) age: 31 (4.7) years vs 27 (5.4) years, P < 0.01] and more likely to be primiparous (70{\%}vs 65{\%}, P < 0.001). After adjusting for age and parity, subfertile women were at increased risk of pre-eclampsia (OR 1.9, 95{\%} CI 1.5-2.5), placenta praevia (OR 3.9, 95{\%} CI 2.2-7.0) and placental abruption (OR 1.8, 95{\%} CI 1.1-3.0), and more likely to undergo induction of labour (OR 1.5, 95{\%} CI 1.3-1.6), caesarean section (OR 2.1, 95{\%} CI 1.8-2.4) and instrumental delivery (OR 2.2, 95{\%} CI 1.8-2.6), and deliver low birthweight (OR 1.4, 95{\%} CI 1.3-1.7) and preterm (OR 1.7, 95{\%} CI 1.2-2.2) infants. There were no differences between treatment-related and treatment-independent pregnancies.Conclusion Subfertile women are at higher risk of obstetric complications, which persist after adjusting for age and parity.",
keywords = "BIRTH-WEIGHT, UNEXPLAINED INFERTILITY, PREGNANCIES, COMPLICATIONS, DELIVERY, SERVICES, HISTORY, COUPLES",
author = "F. Thompson and Smruta Shanbhag and Templeton, {Alexander Allan} and Siladitya Bhattacharya",
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T1 - Obstetric outcome in women with subfertility

AU - Thompson, F.

AU - Shanbhag, Smruta

AU - Templeton, Alexander Allan

AU - Bhattacharya, Siladitya

PY - 2005

Y1 - 2005

N2 - Background It has been suggested that a history of subfertility is associated with increased obstetric and perinatal risks. It is unclear if the cause is inherent characteristics in the women or the fertility treatment.Objectives To compare the obstetric and perinatal risks of singleton pregnancies in women with a history of subfertility in comparison with the general population.Design Population cohort.Setting Aberdeen, Scotland.Population Cases were women attending the Fertility Clinic between 1989 and 1999 who subsequently went on to have singleton pregnancies. Controls included the general population of women who delivered singletons over the same period.Methods We performed a retrospective cohort study to investigate the obstetric outcome of singleton pregnancies in women with subfertility. The general population of women who delivered singletons over the same period served as controls.Main outcome measures Obstetric and perinatal complications in singleton pregnancies.Results Maternity records were available for a total of 1437 subfertile women and 21,688 controls. Subfertile women were older [mean (SD) age: 31 (4.7) years vs 27 (5.4) years, P < 0.01] and more likely to be primiparous (70%vs 65%, P < 0.001). After adjusting for age and parity, subfertile women were at increased risk of pre-eclampsia (OR 1.9, 95% CI 1.5-2.5), placenta praevia (OR 3.9, 95% CI 2.2-7.0) and placental abruption (OR 1.8, 95% CI 1.1-3.0), and more likely to undergo induction of labour (OR 1.5, 95% CI 1.3-1.6), caesarean section (OR 2.1, 95% CI 1.8-2.4) and instrumental delivery (OR 2.2, 95% CI 1.8-2.6), and deliver low birthweight (OR 1.4, 95% CI 1.3-1.7) and preterm (OR 1.7, 95% CI 1.2-2.2) infants. There were no differences between treatment-related and treatment-independent pregnancies.Conclusion Subfertile women are at higher risk of obstetric complications, which persist after adjusting for age and parity.

AB - Background It has been suggested that a history of subfertility is associated with increased obstetric and perinatal risks. It is unclear if the cause is inherent characteristics in the women or the fertility treatment.Objectives To compare the obstetric and perinatal risks of singleton pregnancies in women with a history of subfertility in comparison with the general population.Design Population cohort.Setting Aberdeen, Scotland.Population Cases were women attending the Fertility Clinic between 1989 and 1999 who subsequently went on to have singleton pregnancies. Controls included the general population of women who delivered singletons over the same period.Methods We performed a retrospective cohort study to investigate the obstetric outcome of singleton pregnancies in women with subfertility. The general population of women who delivered singletons over the same period served as controls.Main outcome measures Obstetric and perinatal complications in singleton pregnancies.Results Maternity records were available for a total of 1437 subfertile women and 21,688 controls. Subfertile women were older [mean (SD) age: 31 (4.7) years vs 27 (5.4) years, P < 0.01] and more likely to be primiparous (70%vs 65%, P < 0.001). After adjusting for age and parity, subfertile women were at increased risk of pre-eclampsia (OR 1.9, 95% CI 1.5-2.5), placenta praevia (OR 3.9, 95% CI 2.2-7.0) and placental abruption (OR 1.8, 95% CI 1.1-3.0), and more likely to undergo induction of labour (OR 1.5, 95% CI 1.3-1.6), caesarean section (OR 2.1, 95% CI 1.8-2.4) and instrumental delivery (OR 2.2, 95% CI 1.8-2.6), and deliver low birthweight (OR 1.4, 95% CI 1.3-1.7) and preterm (OR 1.7, 95% CI 1.2-2.2) infants. There were no differences between treatment-related and treatment-independent pregnancies.Conclusion Subfertile women are at higher risk of obstetric complications, which persist after adjusting for age and parity.

KW - BIRTH-WEIGHT

KW - UNEXPLAINED INFERTILITY

KW - PREGNANCIES

KW - COMPLICATIONS

KW - DELIVERY

KW - SERVICES

KW - HISTORY

KW - COUPLES

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JO - BJOG-An International Journal of Obstetrics and Gynaecology

JF - BJOG-An International Journal of Obstetrics and Gynaecology

SN - 1470-0328

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