TY - JOUR
T1 - Occupational socioeconomic risk associations for head and neck cancer in Europe and South America
T2 - individual participant data analysis of pooled case-control studies within the INHANCE Consortium
AU - Conway, David I
AU - Hovanec, Jan
AU - Ahrens, Wolfgang
AU - Ross, Alastair
AU - Holcatova, Ivana
AU - Lagiou, Pagona
AU - Serraino, Diego
AU - Canova, Cristina
AU - Richiardi, Lorenzo
AU - Healy, Claire
AU - Kjaerheim, Kristina
AU - Macfarlane, Gary J
AU - Thomson, Peter
AU - Agudo, Antonio
AU - Znaor, Ariana
AU - Brennan, Paul
AU - Luce, Danièle
AU - Menvielle, Gwenn
AU - Stucker, Isabelle
AU - Benhamou, Simone
AU - Ramroth, Heribert
AU - Boffetta, Paolo
AU - Vilensky, Marta
AU - Fernandez, Leticia
AU - Curado, Maria Paula
AU - Menezes, Ana
AU - Daudt, Alexander
AU - Koifman, Rosalina
AU - Wunsch-Filho, Victor
AU - Yuan-Chin, Amy Lee
AU - Hashibe, Mia
AU - Behrens, Thomas
AU - McMahon, Alex D
N1 - Funding This work was supported by funders of the original studies. ARCAGE (Western Europe): European Community (5th Framework Programme) grant no QLK1-CT-2001-00182; France study: Swiss League against Cancer (KFS1069-09-2000), Fribourg League against Cancer (FOR381.88), Swiss Cancer Research (AKT 617) and Gustave-Roussy Institute (88D28); Germany-Heidelberg study: German Ministry of Education and Research (No. 01GB9702/3); Latin American study: Fondo para la Investigacion Cientifica y Tecnologica (FONCYT) Argentina, IMIM (Barcelona), Fundaco de Amparo a Pesquisa no Estado de Sao Paulo (FAPESP) (No. 01/01768-2), and European Commission (IC18-CT97-0222); INHANCE Pooled Data Project: NCI (R03CA113157, NIDCR R03DE016611). ICARE (France 2001–2007): French National Research Agency (ANR); French National Cancer Institute (INCA); French Agency for Food, Environmental and Occupational Health and Safety (ANSES); French Institute for Public Health Surveillance (InVS); Fondation pour la Recherche Médicale (FRM); Fondation de France; Fondation ARC pour la Recherche sur le Cancer; French Ministry of Labour (Direction Générale du Travail); French Ministry of Health (Direction Générale de la Santé).
PY - 2021/7/9
Y1 - 2021/7/9
N2 - BACKGROUND: The association between socioeconomic disadvantage (low education and/or income) and head and neck cancer is well established, with smoking and alcohol consumption explaining up to three-quarters of the risk. We aimed to investigate the nature of and explanations for head and neck cancer risk associated with occupational socioeconomic prestige (a perceptual measure of psychosocial status), occupational socioeconomic position and manual-work experience, and to assess the potential explanatory role of occupational exposures.METHODS: Pooled analysis included 5818 patients with head and neck cancer (and 7326 control participants) from five studies in Europe and South America. Lifetime job histories were coded to: (1) occupational social prestige-Treiman's Standard International Occupational Prestige Scale (SIOPS); (2) occupational socioeconomic position-International Socio-Economic Index (ISEI); and (3) manual/non-manual jobs.RESULTS: For the longest held job, adjusting for smoking, alcohol and nature of occupation, increased head and neck cancer risk estimates were observed for low SIOPS OR=1.88 (95% CI: 1.64 to 2.17), low ISEI OR=1.74 (95% CI: 1.51 to 1.99) and manual occupations OR=1.49 (95% CI: 1.35 to 1.64). Following mutual adjustment by socioeconomic exposures, risk associated with low SIOPS remained OR=1.59 (95% CI: 1.30 to 1.94).CONCLUSIONS: These findings indicate that low occupational socioeconomic prestige, position and manual work are associated with head and neck cancer, and such risks are only partly explained by smoking, alcohol and occupational exposures. Perceptual occupational psychosocial status (SIOPS) appears to be the strongest socioeconomic factor, relative to socioeconomic position and manual/non-manual work.
AB - BACKGROUND: The association between socioeconomic disadvantage (low education and/or income) and head and neck cancer is well established, with smoking and alcohol consumption explaining up to three-quarters of the risk. We aimed to investigate the nature of and explanations for head and neck cancer risk associated with occupational socioeconomic prestige (a perceptual measure of psychosocial status), occupational socioeconomic position and manual-work experience, and to assess the potential explanatory role of occupational exposures.METHODS: Pooled analysis included 5818 patients with head and neck cancer (and 7326 control participants) from five studies in Europe and South America. Lifetime job histories were coded to: (1) occupational social prestige-Treiman's Standard International Occupational Prestige Scale (SIOPS); (2) occupational socioeconomic position-International Socio-Economic Index (ISEI); and (3) manual/non-manual jobs.RESULTS: For the longest held job, adjusting for smoking, alcohol and nature of occupation, increased head and neck cancer risk estimates were observed for low SIOPS OR=1.88 (95% CI: 1.64 to 2.17), low ISEI OR=1.74 (95% CI: 1.51 to 1.99) and manual occupations OR=1.49 (95% CI: 1.35 to 1.64). Following mutual adjustment by socioeconomic exposures, risk associated with low SIOPS remained OR=1.59 (95% CI: 1.30 to 1.94).CONCLUSIONS: These findings indicate that low occupational socioeconomic prestige, position and manual work are associated with head and neck cancer, and such risks are only partly explained by smoking, alcohol and occupational exposures. Perceptual occupational psychosocial status (SIOPS) appears to be the strongest socioeconomic factor, relative to socioeconomic position and manual/non-manual work.
KW - cancer epidemiology
KW - cancer: occupational
KW - socioeconomic
U2 - 10.1136/jech-2020-214913
DO - 10.1136/jech-2020-214913
M3 - Article
C2 - 33622804
VL - 75
SP - 779
EP - 787
JO - Journal of Epidemiology and Community Health
JF - Journal of Epidemiology and Community Health
SN - 0143-005X
ER -
