On the Road to Immunotherapy

Prospects for Treating Head and Neck Cancers With Checkpoint Inhibitor Antibodies

Frank J. Ward (Corresponding Author), Lekh N. Dahal, Rasha Abu-Eid

Research output: Contribution to journalReview article

4 Citations (Scopus)
3 Downloads (Pure)

Abstract

Head and neck cancers (HNC) represent a heterogeneous cluster of aggressive malignancies that account for 3% of all cancer cases in the UK. HNC is increasing in frequency particularly in the developing world, which is related to changes in risk factors. Unfortunately, the mortality rate is high, which is chiefly attributed to late diagnosis at stages where traditional treatments fail. Cancer immunotherapy has achieved great successes in anti-tumor therapy. Checkpoint inhibitor (CI) antibodies enhance anti-tumor activity by blocking inhibitory receptors to drive tumor-specific T and NK cell effector responses. Since their introduction in 2011, CI antibodies have been approved for many cancer types including HNC. Here, we examine the development of CI therapies and look forward to future developments for treatment of HNC with CI therapies.

Original languageEnglish
Article number2182
Number of pages12
JournalFrontiers in Immunology
Volume9
DOIs
Publication statusPublished - 24 Sep 2018

Fingerprint

Head and Neck Neoplasms
Immunotherapy
Antibodies
Neoplasms
Therapeutics
Delayed Diagnosis
Natural Killer Cells
Anti-Idiotypic Antibodies
T-Lymphocytes
Mortality

Keywords

  • checkpoint inhibitor
  • head and neck squamous cell carcinoma
  • immunotherapy
  • PD-1
  • T cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

@article{0acfe49a98354279b50298af6a1898ae,
title = "On the Road to Immunotherapy: Prospects for Treating Head and Neck Cancers With Checkpoint Inhibitor Antibodies",
abstract = "Head and neck cancers (HNC) represent a heterogeneous cluster of aggressive malignancies that account for 3{\%} of all cancer cases in the UK. HNC is increasing in frequency particularly in the developing world, which is related to changes in risk factors. Unfortunately, the mortality rate is high, which is chiefly attributed to late diagnosis at stages where traditional treatments fail. Cancer immunotherapy has achieved great successes in anti-tumor therapy. Checkpoint inhibitor (CI) antibodies enhance anti-tumor activity by blocking inhibitory receptors to drive tumor-specific T and NK cell effector responses. Since their introduction in 2011, CI antibodies have been approved for many cancer types including HNC. Here, we examine the development of CI therapies and look forward to future developments for treatment of HNC with CI therapies.",
keywords = "checkpoint inhibitor, head and neck squamous cell carcinoma, immunotherapy, PD-1, T cells",
author = "Ward, {Frank J.} and Dahal, {Lekh N.} and Rasha Abu-Eid",
year = "2018",
month = "9",
day = "24",
doi = "10.3389/fimmu.2018.02182",
language = "English",
volume = "9",
journal = "Frontiers in Immunology",
issn = "1664-3224",
publisher = "Frontiers Media S.A.",

}

TY - JOUR

T1 - On the Road to Immunotherapy

T2 - Prospects for Treating Head and Neck Cancers With Checkpoint Inhibitor Antibodies

AU - Ward, Frank J.

AU - Dahal, Lekh N.

AU - Abu-Eid, Rasha

PY - 2018/9/24

Y1 - 2018/9/24

N2 - Head and neck cancers (HNC) represent a heterogeneous cluster of aggressive malignancies that account for 3% of all cancer cases in the UK. HNC is increasing in frequency particularly in the developing world, which is related to changes in risk factors. Unfortunately, the mortality rate is high, which is chiefly attributed to late diagnosis at stages where traditional treatments fail. Cancer immunotherapy has achieved great successes in anti-tumor therapy. Checkpoint inhibitor (CI) antibodies enhance anti-tumor activity by blocking inhibitory receptors to drive tumor-specific T and NK cell effector responses. Since their introduction in 2011, CI antibodies have been approved for many cancer types including HNC. Here, we examine the development of CI therapies and look forward to future developments for treatment of HNC with CI therapies.

AB - Head and neck cancers (HNC) represent a heterogeneous cluster of aggressive malignancies that account for 3% of all cancer cases in the UK. HNC is increasing in frequency particularly in the developing world, which is related to changes in risk factors. Unfortunately, the mortality rate is high, which is chiefly attributed to late diagnosis at stages where traditional treatments fail. Cancer immunotherapy has achieved great successes in anti-tumor therapy. Checkpoint inhibitor (CI) antibodies enhance anti-tumor activity by blocking inhibitory receptors to drive tumor-specific T and NK cell effector responses. Since their introduction in 2011, CI antibodies have been approved for many cancer types including HNC. Here, we examine the development of CI therapies and look forward to future developments for treatment of HNC with CI therapies.

KW - checkpoint inhibitor

KW - head and neck squamous cell carcinoma

KW - immunotherapy

KW - PD-1

KW - T cells

UR - http://www.scopus.com/inward/record.url?scp=85054894005&partnerID=8YFLogxK

U2 - 10.3389/fimmu.2018.02182

DO - 10.3389/fimmu.2018.02182

M3 - Review article

VL - 9

JO - Frontiers in Immunology

JF - Frontiers in Immunology

SN - 1664-3224

M1 - 2182

ER -