One year prospective survey of Candida bloodstream infections in Scotland

Frank Christopher Odds, Mary F. Hanson, Amanda Denise Davidson, Mette D. Jacobsen, Pauline Wright, Julie A. Whyte, Neil A. R. Gow, Brian L. Jones

Research output: Contribution to journalArticle

135 Citations (Scopus)

Abstract

A 12 month survey of candidaemia in Scotland, UK, in which every Scottish hospital laboratory submitted all blood isolates of yeasts for identification, strain typing and susceptibility testing, provided 300 isolates from 242 patients, generating incidence data of 4.8 cases per 100 000 population per year and 5.9 cases per 100 000 acute occupied bed days; 27.9 % of cases occurred in intensive care units. More than half the patients with candidaemia had an underlying disease involving the abdomen, 78 % had an indwelling intravenous catheter, 62 % had suffered a bacterial infection within the 2 weeks prior to candidaemia and 37 % had undergone a laparotomy. Candida albicans was the infecting species in 50 % of cases, followed by Candida glabrata (21 %) and Candida parapsilosis (12 %). Seven cases of candidaemia were caused by Candida dubliniensis, which was more prevalent even than Candida lusitaniae and Candida tropicalis (six cases each). Among C. glabrata isolates, 55 % showed reduced susceptibility to fluconazole, but azole resistance among other species was extremely low. Multilocus sequence typing showed isolates with high similarity came from different hospitals across the country, and many different types came from the hospitals that submitted [he most isolates, indicating no tendency towards hospital-specific endemic strains. Multiple isolates of C. albicans and C. glabrata from individual patients were of the same strain type with single exceptions for each species. The high prevalence of candidaemia in Scotland, relative to other population-based European studies, and the high level of reduced fluconazole susceptibility of Scottish C. glabrata isolates warrant continued future surveillance of invasive Candida infections.

Original languageEnglish
Pages (from-to)1066-1075
Number of pages10
JournalJournal of Medical Microbiology
Volume56
Issue number8
DOIs
Publication statusPublished - Aug 2007

Keywords

  • in-vitro susceptibilities
  • care unit patients
  • antifungal susceptibility
  • intensive-care
  • surveillance program
  • invasive candidiasis
  • active surveillance
  • European committee
  • secular trends
  • albicans

Cite this

Odds, F. C., Hanson, M. F., Davidson, A. D., Jacobsen, M. D., Wright, P., Whyte, J. A., ... Jones, B. L. (2007). One year prospective survey of Candida bloodstream infections in Scotland. Journal of Medical Microbiology, 56(8), 1066-1075. https://doi.org/10.1099/jmm.0.47239-0

One year prospective survey of Candida bloodstream infections in Scotland. / Odds, Frank Christopher; Hanson, Mary F.; Davidson, Amanda Denise; Jacobsen, Mette D.; Wright, Pauline; Whyte, Julie A.; Gow, Neil A. R.; Jones, Brian L.

In: Journal of Medical Microbiology, Vol. 56, No. 8, 08.2007, p. 1066-1075.

Research output: Contribution to journalArticle

Odds, FC, Hanson, MF, Davidson, AD, Jacobsen, MD, Wright, P, Whyte, JA, Gow, NAR & Jones, BL 2007, 'One year prospective survey of Candida bloodstream infections in Scotland', Journal of Medical Microbiology, vol. 56, no. 8, pp. 1066-1075. https://doi.org/10.1099/jmm.0.47239-0
Odds FC, Hanson MF, Davidson AD, Jacobsen MD, Wright P, Whyte JA et al. One year prospective survey of Candida bloodstream infections in Scotland. Journal of Medical Microbiology. 2007 Aug;56(8):1066-1075. https://doi.org/10.1099/jmm.0.47239-0
Odds, Frank Christopher ; Hanson, Mary F. ; Davidson, Amanda Denise ; Jacobsen, Mette D. ; Wright, Pauline ; Whyte, Julie A. ; Gow, Neil A. R. ; Jones, Brian L. / One year prospective survey of Candida bloodstream infections in Scotland. In: Journal of Medical Microbiology. 2007 ; Vol. 56, No. 8. pp. 1066-1075.
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abstract = "A 12 month survey of candidaemia in Scotland, UK, in which every Scottish hospital laboratory submitted all blood isolates of yeasts for identification, strain typing and susceptibility testing, provided 300 isolates from 242 patients, generating incidence data of 4.8 cases per 100 000 population per year and 5.9 cases per 100 000 acute occupied bed days; 27.9 {\%} of cases occurred in intensive care units. More than half the patients with candidaemia had an underlying disease involving the abdomen, 78 {\%} had an indwelling intravenous catheter, 62 {\%} had suffered a bacterial infection within the 2 weeks prior to candidaemia and 37 {\%} had undergone a laparotomy. Candida albicans was the infecting species in 50 {\%} of cases, followed by Candida glabrata (21 {\%}) and Candida parapsilosis (12 {\%}). Seven cases of candidaemia were caused by Candida dubliniensis, which was more prevalent even than Candida lusitaniae and Candida tropicalis (six cases each). Among C. glabrata isolates, 55 {\%} showed reduced susceptibility to fluconazole, but azole resistance among other species was extremely low. Multilocus sequence typing showed isolates with high similarity came from different hospitals across the country, and many different types came from the hospitals that submitted [he most isolates, indicating no tendency towards hospital-specific endemic strains. Multiple isolates of C. albicans and C. glabrata from individual patients were of the same strain type with single exceptions for each species. The high prevalence of candidaemia in Scotland, relative to other population-based European studies, and the high level of reduced fluconazole susceptibility of Scottish C. glabrata isolates warrant continued future surveillance of invasive Candida infections.",
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