oPer1 is an early response gene under photoperiodic regulation in the ovine pars tuberalis

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Abstract

Mammalian Per1 (or RIGUI) is a recently described putative clock gene that is expressed in the suprachiasmatic nucleus. It is also expressed in the pars tuberalis (PT) of the pituitary, where melatonin appears to drive its expression. This study examines the regulation of Per1 expression, In ovine PT cells, oPer1 is an early response gene transiently expressed after stimulation with forskolin, but melatonin has no independent effect on its expression. In sheep, PT tissue photoperiodic background influences the magnitude or timing of expression of oPer1 2 h after lights-on. These data demonstrate that oPer1 mRNA is elevated in the PT following the decline in night-time melatonin, and that the amplitude or timing of this elevation is dependent upon the duration of the nocturnal melatonin signal.

Original languageEnglish
Pages (from-to)319-323
Number of pages5
JournalJournal of Neuroendocrinology
Volume10
Issue number5
DOIs
Publication statusPublished - May 1998

Keywords

  • RIGUI
  • PER
  • melatonin
  • SCN
  • early response gene
  • photoperiod
  • pituitary
  • cells
  • prolactin
  • gland

Cite this

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title = "oPer1 is an early response gene under photoperiodic regulation in the ovine pars tuberalis",
abstract = "Mammalian Per1 (or RIGUI) is a recently described putative clock gene that is expressed in the suprachiasmatic nucleus. It is also expressed in the pars tuberalis (PT) of the pituitary, where melatonin appears to drive its expression. This study examines the regulation of Per1 expression, In ovine PT cells, oPer1 is an early response gene transiently expressed after stimulation with forskolin, but melatonin has no independent effect on its expression. In sheep, PT tissue photoperiodic background influences the magnitude or timing of expression of oPer1 2 h after lights-on. These data demonstrate that oPer1 mRNA is elevated in the PT following the decline in night-time melatonin, and that the amplitude or timing of this elevation is dependent upon the duration of the nocturnal melatonin signal.",
keywords = "RIGUI, PER, melatonin, SCN, early response gene, photoperiod, pituitary, cells, prolactin, gland",
author = "Morgan, {Peter John} and Alexander Ross and Graham, {E S} and Adam, {Clare Lesley} and S Messager and Perry Barrett",
year = "1998",
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doi = "10.1046/j.1365-2826.1998.00232.x",
language = "English",
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journal = "Journal of Neuroendocrinology",
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TY - JOUR

T1 - oPer1 is an early response gene under photoperiodic regulation in the ovine pars tuberalis

AU - Morgan, Peter John

AU - Ross, Alexander

AU - Graham, E S

AU - Adam, Clare Lesley

AU - Messager, S

AU - Barrett, Perry

PY - 1998/5

Y1 - 1998/5

N2 - Mammalian Per1 (or RIGUI) is a recently described putative clock gene that is expressed in the suprachiasmatic nucleus. It is also expressed in the pars tuberalis (PT) of the pituitary, where melatonin appears to drive its expression. This study examines the regulation of Per1 expression, In ovine PT cells, oPer1 is an early response gene transiently expressed after stimulation with forskolin, but melatonin has no independent effect on its expression. In sheep, PT tissue photoperiodic background influences the magnitude or timing of expression of oPer1 2 h after lights-on. These data demonstrate that oPer1 mRNA is elevated in the PT following the decline in night-time melatonin, and that the amplitude or timing of this elevation is dependent upon the duration of the nocturnal melatonin signal.

AB - Mammalian Per1 (or RIGUI) is a recently described putative clock gene that is expressed in the suprachiasmatic nucleus. It is also expressed in the pars tuberalis (PT) of the pituitary, where melatonin appears to drive its expression. This study examines the regulation of Per1 expression, In ovine PT cells, oPer1 is an early response gene transiently expressed after stimulation with forskolin, but melatonin has no independent effect on its expression. In sheep, PT tissue photoperiodic background influences the magnitude or timing of expression of oPer1 2 h after lights-on. These data demonstrate that oPer1 mRNA is elevated in the PT following the decline in night-time melatonin, and that the amplitude or timing of this elevation is dependent upon the duration of the nocturnal melatonin signal.

KW - RIGUI

KW - PER

KW - melatonin

KW - SCN

KW - early response gene

KW - photoperiod

KW - pituitary

KW - cells

KW - prolactin

KW - gland

U2 - 10.1046/j.1365-2826.1998.00232.x

DO - 10.1046/j.1365-2826.1998.00232.x

M3 - Article

VL - 10

SP - 319

EP - 323

JO - Journal of Neuroendocrinology

JF - Journal of Neuroendocrinology

SN - 0953-8194

IS - 5

ER -