Ophiobolin sesterterpenoids and pyrrolidine alkaloids from the sponge-derived fungus Aspergillus ustus

Hong-Bing Liu, RuAngelie Edrada-Ebel, Rainer Ebel, Yao Wang, Barbara Schulz, Siegfried Draeger, Werner E.G. Müller, Victor Wray, Wen-Han Lin, Peter Proksch

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Chemical examination of the fungus Aspergillus ustus isolated from the Mediterranean sponge Suberites domuncula yielded the five new ophiobolin-type sesterterpenoids 1-5 and the two new pyrrolidine alkaloids 6 and 7, together with the known compound aurantiamine and cerebroside D. The structures of the new compounds were unambiguously elucidated on the basis of extensive spectroscopic-data analysis (1D- and 2D-NMR, MS, and UV) and comparison with literature data. All compounds were evaluated for their cytotoxicity against murine lymphoma cell line L5178Y.
Original languageEnglish
Pages (from-to)623-631
Number of pages9
JournalHelvetica Chimica Acta
Volume94
Issue number4
DOIs
Publication statusPublished - Apr 2011

Keywords

  • Aspergillus ustus
  • Suberites domuncula
  • fungi
  • sesterterpenoids
  • pyrrolidine alkaloids
  • cytotoxic activity
  • alkaloids

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