Chemical examination of the fungus Aspergillus ustus isolated from the Mediterranean sponge Suberites domuncula yielded the five new ophiobolin-type sesterterpenoids 1-5 and the two new pyrrolidine alkaloids 6 and 7, together with the known compound aurantiamine and cerebroside D. The structures of the new compounds were unambiguously elucidated on the basis of extensive spectroscopic-data analysis (1D- and 2D-NMR, MS, and UV) and comparison with literature data. All compounds were evaluated for their cytotoxicity against murine lymphoma cell line L5178Y.
- Aspergillus ustus
- Suberites domuncula
- pyrrolidine alkaloids
- cytotoxic activity
Liu, H-B., Edrada-Ebel, R., Ebel, R., Wang, Y., Schulz, B., Draeger, S., Müller, W. E. G., Wray, V., Lin, W-H., & Proksch, P. (2011). Ophiobolin sesterterpenoids and pyrrolidine alkaloids from the sponge-derived fungus Aspergillus ustus. Helvetica Chimica Acta, 94(4), 623-631. https://doi.org/10.1002/hlca.201000283