Ophiobolin sesterterpenoids and pyrrolidine alkaloids from the sponge-derived fungus Aspergillus ustus

Hong-Bing Liu, RuAngelie Edrada-Ebel, Rainer Ebel, Yao Wang, Barbara Schulz, Siegfried Draeger, Werner E.G. Müller, Victor Wray, Wen-Han Lin, Peter Proksch

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Chemical examination of the fungus Aspergillus ustus isolated from the Mediterranean sponge Suberites domuncula yielded the five new ophiobolin-type sesterterpenoids 1-5 and the two new pyrrolidine alkaloids 6 and 7, together with the known compound aurantiamine and cerebroside D. The structures of the new compounds were unambiguously elucidated on the basis of extensive spectroscopic-data analysis (1D- and 2D-NMR, MS, and UV) and comparison with literature data. All compounds were evaluated for their cytotoxicity against murine lymphoma cell line L5178Y.
Original languageEnglish
Pages (from-to)623-631
Number of pages9
JournalHelvetica Chimica Acta
Volume94
Issue number4
DOIs
Publication statusPublished - Apr 2011

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Suberites
Aspergillus
Alkaloids
alkaloids
fungi
Porifera
Cytotoxicity
Fungi
cultured cells
Lymphoma
examination
Cells
Nuclear magnetic resonance
Cell Line
nuclear magnetic resonance
ophiobolins
cerebroside D
pyrrolidine
aurantiamine

Keywords

  • Aspergillus ustus
  • Suberites domuncula
  • fungi
  • sesterterpenoids
  • pyrrolidine alkaloids
  • cytotoxic activity
  • alkaloids

Cite this

Ophiobolin sesterterpenoids and pyrrolidine alkaloids from the sponge-derived fungus Aspergillus ustus. / Liu, Hong-Bing; Edrada-Ebel, RuAngelie; Ebel, Rainer; Wang, Yao; Schulz, Barbara; Draeger, Siegfried; Müller, Werner E.G.; Wray, Victor; Lin, Wen-Han; Proksch, Peter.

In: Helvetica Chimica Acta, Vol. 94, No. 4, 04.2011, p. 623-631.

Research output: Contribution to journalArticle

Liu, H-B, Edrada-Ebel, R, Ebel, R, Wang, Y, Schulz, B, Draeger, S, Müller, WEG, Wray, V, Lin, W-H & Proksch, P 2011, 'Ophiobolin sesterterpenoids and pyrrolidine alkaloids from the sponge-derived fungus Aspergillus ustus', Helvetica Chimica Acta, vol. 94, no. 4, pp. 623-631. https://doi.org/10.1002/hlca.201000283
Liu, Hong-Bing ; Edrada-Ebel, RuAngelie ; Ebel, Rainer ; Wang, Yao ; Schulz, Barbara ; Draeger, Siegfried ; Müller, Werner E.G. ; Wray, Victor ; Lin, Wen-Han ; Proksch, Peter. / Ophiobolin sesterterpenoids and pyrrolidine alkaloids from the sponge-derived fungus Aspergillus ustus. In: Helvetica Chimica Acta. 2011 ; Vol. 94, No. 4. pp. 623-631.
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