Optimal placement of origins for DNA replication

Jens Karschau, J. Julian Blow, Alessandro P. S. de Moura

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Abstract

DNA replication is an essential process in biology and its timing must be robust so that cells can divide properly. Random fluctuations in the formation of replication starting points, called origins, and the subsequent activation of proteins lead to variations in the replication time. We analyze these stochastic properties of DNA and derive the positions of origins corresponding to the minimum replication time. We show that under some conditions the minimization of replication time leads to the grouping of origins, and relate this to experimental data in a number of species showing origin grouping.
Original languageEnglish
Article number058101
Number of pages5
JournalPhysical Review Letters
Volume108
Issue number5
Early online date30 Jan 2012
DOIs
Publication statusPublished - 3 Feb 2012

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deoxyribonucleic acid
biology
time measurement
activation
proteins
optimization
cells

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Optimal placement of origins for DNA replication. / Karschau, Jens; Blow, J. Julian; de Moura, Alessandro P. S.

In: Physical Review Letters, Vol. 108, No. 5, 058101, 03.02.2012.

Research output: Contribution to journalArticle

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