Optimisation of the aqueous precipitation synthesis of silicate-substituted hydroxyapatite

Daniel James Hadden, Jan Skakle, Iain Ronald Gibson

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Silicon-substituted hydroxyapatite (SiHA) bioceramics are widely used as bone replacement materials. There are various synthesis methods used to produce SiHA samples using different sources of silicon. This study aims to investigate the role of tetraethyl orthosilicate (TEOS) as the silicon source in the precipitation reaction synthesis of silicate-substituted HA. Four different synthesis methods were studied by changing the order of addition of the TEOS solution during the precipitation reaction. XRD and QXRD were used to determine the phase purity of the prepared samples. FTIR and SSNMR were used to assess silicon/silicate substitution in the prepared materials. Of the initial four methods used, only one resulted in a sample that was phase pure. The other three syntheses, which produced biphasic compositions, were modified and a further single phase sample was prepared. Results showed that the final composition is strongly dependant on how and when the TEOS was added during the precipitation reaction.

Original languageEnglish
Title of host publicationBioceramics
EditorsGuy Daculsi, Pierre Layrolle
Place of PublicationZurich, Switzerland
PublisherTrans Tech Publications Ltd
Pages55-58
Number of pages4
Volume20
Edition1-2
ISBN (Print)087849457X, 978-0878494576
Publication statusPublished - 30 Mar 2008
Event20th International Symposium on Ceramics in Medicine - Nantes, France
Duration: 24 Oct 200726 Oct 2007

Publication series

NameKey Engineering Materials
PublisherTrans Tech Publications Ltd
Volume361-363
ISSN (Print)1013-9826

Conference

Conference20th International Symposium on Ceramics in Medicine
CountryFrance
CityNantes
Period24/10/0726/10/07

Keywords

  • hydroxyapatite
  • silicate
  • silicon
  • substitution
  • X-ray diffraction

Cite this

Hadden, D. J., Skakle, J., & Gibson, I. R. (2008). Optimisation of the aqueous precipitation synthesis of silicate-substituted hydroxyapatite. In G. Daculsi, & P. Layrolle (Eds.), Bioceramics (1-2 ed., Vol. 20, pp. 55-58). (Key Engineering Materials; Vol. 361-363). Zurich, Switzerland: Trans Tech Publications Ltd.

Optimisation of the aqueous precipitation synthesis of silicate-substituted hydroxyapatite. / Hadden, Daniel James; Skakle, Jan; Gibson, Iain Ronald.

Bioceramics. ed. / Guy Daculsi; Pierre Layrolle. Vol. 20 1-2. ed. Zurich, Switzerland : Trans Tech Publications Ltd, 2008. p. 55-58 (Key Engineering Materials; Vol. 361-363).

Research output: Chapter in Book/Report/Conference proceedingChapter

Hadden, DJ, Skakle, J & Gibson, IR 2008, Optimisation of the aqueous precipitation synthesis of silicate-substituted hydroxyapatite. in G Daculsi & P Layrolle (eds), Bioceramics. 1-2 edn, vol. 20, Key Engineering Materials, vol. 361-363, Trans Tech Publications Ltd, Zurich, Switzerland, pp. 55-58, 20th International Symposium on Ceramics in Medicine , Nantes, France, 24/10/07.
Hadden DJ, Skakle J, Gibson IR. Optimisation of the aqueous precipitation synthesis of silicate-substituted hydroxyapatite. In Daculsi G, Layrolle P, editors, Bioceramics. 1-2 ed. Vol. 20. Zurich, Switzerland: Trans Tech Publications Ltd. 2008. p. 55-58. (Key Engineering Materials).
Hadden, Daniel James ; Skakle, Jan ; Gibson, Iain Ronald. / Optimisation of the aqueous precipitation synthesis of silicate-substituted hydroxyapatite. Bioceramics. editor / Guy Daculsi ; Pierre Layrolle. Vol. 20 1-2. ed. Zurich, Switzerland : Trans Tech Publications Ltd, 2008. pp. 55-58 (Key Engineering Materials).
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