Optimised MR imaging for polyacrylamide gel dosimetry

IC Baustert, Mark Oldham, Timothy Andrew Davies Smith, C Hayes, Steve Webb, Martin Leach

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Polyacrylamide gels are a powerful tool to measure radiation dose by quantifying the NMR T 2 relaxation times of the irradiated gel. The exploitation of these radiation sensitive gels in clinical radiotherapy requires accurate mapping of T 2 values. This paper describes the optimization strategy used to identify accurate and practical methods of measuring the range of T 2 values typical of gel dosimeters (140-700 ms). The MR imaging techniques used to measure T 2 values and the choice of image acquisition parameters are described. Four sequences are compared and the results are analysed in terms of accuracy, signal-to-noise ratio and acquisition time. A multiple spin echo sequence was found to yield the most accurate results (98.9%). Single spin echo sequences, such as Hahn spin echo and EPI spin echo, were found to measure gel T 2 values with an accuracy of 90.1%. This paper reports the importance of careful selection and optimization of the MR imaging sequences for accurate and reliable polyacrylamide gel dosimetry.

Original languageEnglish
Pages (from-to)845-857
Number of pages13
JournalPhysics in Medicine and Biology
Volume45
Issue number4
DOIs
Publication statusPublished - 1 Jan 2000

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Gels
Radiation
Signal-To-Noise Ratio
Radiotherapy
polyacrylamide gels

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Baustert, IC., Oldham, M., Smith, T. A. D., Hayes, C., Webb, S., & Leach, M. (2000). Optimised MR imaging for polyacrylamide gel dosimetry. Physics in Medicine and Biology, 45(4), 845-857. https://doi.org/10.1088/0031-9155/45/4/303

Optimised MR imaging for polyacrylamide gel dosimetry. / Baustert, IC; Oldham, Mark; Smith, Timothy Andrew Davies; Hayes, C; Webb, Steve; Leach, Martin .

In: Physics in Medicine and Biology, Vol. 45, No. 4, 01.01.2000, p. 845-857.

Research output: Contribution to journalArticle

Baustert, IC, Oldham, M, Smith, TAD, Hayes, C, Webb, S & Leach, M 2000, 'Optimised MR imaging for polyacrylamide gel dosimetry', Physics in Medicine and Biology, vol. 45, no. 4, pp. 845-857. https://doi.org/10.1088/0031-9155/45/4/303
Baustert IC, Oldham M, Smith TAD, Hayes C, Webb S, Leach M. Optimised MR imaging for polyacrylamide gel dosimetry. Physics in Medicine and Biology. 2000 Jan 1;45(4):845-857. https://doi.org/10.1088/0031-9155/45/4/303
Baustert, IC ; Oldham, Mark ; Smith, Timothy Andrew Davies ; Hayes, C ; Webb, Steve ; Leach, Martin . / Optimised MR imaging for polyacrylamide gel dosimetry. In: Physics in Medicine and Biology. 2000 ; Vol. 45, No. 4. pp. 845-857.
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