Oral human papillomavirus infection in England and associated risk factors

a case-control study

Vanessa Hearnden (Corresponding Author), Craig Murdoch, Katy D'Apice, Susan Duthie, Nicholas J Hayward, Hilary Jane Powers

Research output: Contribution to journalArticle

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Abstract

OBJECTIVES: This study was conducted to determine the prevalence of and associated risk factors for infection with oral high-risk human papillomavirus (HR-HPV) in adult participants within England, and to explore any association with oral mucosal buccal epithelial cell and whole blood folate concentration.

DESIGN: This was an observational study to determine oral HR-HPV prevalence in the study population. A case-control study was performed to explore the association between infection and folate status.

SETTING: This study was conducted in Sheffield, UK, between April 2013 and August 2014.

PARTICIPANTS: Seven hundred participants, aged 18-60 years, were recruited from university students (n=179), university and hospital staff (n=163), dental hospital patients (n=13), Sexual Health Sheffield patients (n=122) and the general public (n=223).

INTERVENTIONS: Participants completed a lifestyle and sexual behaviour questionnaire, provided an oral rinse and gargle sample for the detection of oral HR-HPV and an oral mucosal buccal epithelial cell sample for the measurement of oral mucosal buccal epithelial cell folate. A blood sample was collected for measurement of whole blood folate concentration.

OUTCOME MEASURES: The prevalence of oral HR-HPV infection in the study population was the primary outcome measure. Secondary outcome measures included associations between risk factors, folate status and infection.

RESULTS: The prevalence of oral HR-HPV infection in this cohort was 2.2% (15/680) with 0.7% (5/680) positive for HPV16 or HPV18. Twenty samples were excluded due to insufficient material for HPV detection. Participants with oral HR-HPV infection were more likely to be a former smoker, and have a greater number of sexual and oral sexual partners. Folate status was not linked to likelihood of HPV infection.

CONCLUSIONS: The prevalence of oral infection with HR-HPV in adult men and women in Sheffield in the North of England was low. Smoking and sexual behaviour were associated with HR-HPV positivity.

TRIAL REGISTRATION NUMBER: ID14106.

Original languageEnglish
Article numbere022497
JournalBMJ Open
Volume8
Issue number8
Early online date19 Aug 2018
DOIs
Publication statusPublished - Nov 2018

Fingerprint

Papillomavirus Infections
England
Case-Control Studies
Folic Acid
Cheek
Infection
Epithelial Cells
Sexual Behavior
Outcome Assessment (Health Care)
Sexual Partners
Reproductive Health
Population
Observational Studies
Life Style
Tooth
Cross-Sectional Studies
Smoking
Students

Cite this

Hearnden, V., Murdoch, C., D'Apice, K., Duthie, S., Hayward, N. J., & Powers, H. J. (2018). Oral human papillomavirus infection in England and associated risk factors: a case-control study. BMJ Open, 8(8), [e022497]. https://doi.org/10.1136/bmjopen-2018-022497

Oral human papillomavirus infection in England and associated risk factors : a case-control study. / Hearnden, Vanessa (Corresponding Author); Murdoch, Craig; D'Apice, Katy; Duthie, Susan; Hayward, Nicholas J; Powers, Hilary Jane.

In: BMJ Open, Vol. 8, No. 8, e022497, 11.2018.

Research output: Contribution to journalArticle

Hearnden, V, Murdoch, C, D'Apice, K, Duthie, S, Hayward, NJ & Powers, HJ 2018, 'Oral human papillomavirus infection in England and associated risk factors: a case-control study', BMJ Open, vol. 8, no. 8, e022497. https://doi.org/10.1136/bmjopen-2018-022497
Hearnden, Vanessa ; Murdoch, Craig ; D'Apice, Katy ; Duthie, Susan ; Hayward, Nicholas J ; Powers, Hilary Jane. / Oral human papillomavirus infection in England and associated risk factors : a case-control study. In: BMJ Open. 2018 ; Vol. 8, No. 8.
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AU - Hearnden, Vanessa

AU - Murdoch, Craig

AU - D'Apice, Katy

AU - Duthie, Susan

AU - Hayward, Nicholas J

AU - Powers, Hilary Jane

N1 - © Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

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N2 - OBJECTIVES: This study was conducted to determine the prevalence of and associated risk factors for infection with oral high-risk human papillomavirus (HR-HPV) in adult participants within England, and to explore any association with oral mucosal buccal epithelial cell and whole blood folate concentration.DESIGN: This was an observational study to determine oral HR-HPV prevalence in the study population. A case-control study was performed to explore the association between infection and folate status.SETTING: This study was conducted in Sheffield, UK, between April 2013 and August 2014.PARTICIPANTS: Seven hundred participants, aged 18-60 years, were recruited from university students (n=179), university and hospital staff (n=163), dental hospital patients (n=13), Sexual Health Sheffield patients (n=122) and the general public (n=223).INTERVENTIONS: Participants completed a lifestyle and sexual behaviour questionnaire, provided an oral rinse and gargle sample for the detection of oral HR-HPV and an oral mucosal buccal epithelial cell sample for the measurement of oral mucosal buccal epithelial cell folate. A blood sample was collected for measurement of whole blood folate concentration.OUTCOME MEASURES: The prevalence of oral HR-HPV infection in the study population was the primary outcome measure. Secondary outcome measures included associations between risk factors, folate status and infection.RESULTS: The prevalence of oral HR-HPV infection in this cohort was 2.2% (15/680) with 0.7% (5/680) positive for HPV16 or HPV18. Twenty samples were excluded due to insufficient material for HPV detection. Participants with oral HR-HPV infection were more likely to be a former smoker, and have a greater number of sexual and oral sexual partners. Folate status was not linked to likelihood of HPV infection.CONCLUSIONS: The prevalence of oral infection with HR-HPV in adult men and women in Sheffield in the North of England was low. Smoking and sexual behaviour were associated with HR-HPV positivity.TRIAL REGISTRATION NUMBER: ID14106.

AB - OBJECTIVES: This study was conducted to determine the prevalence of and associated risk factors for infection with oral high-risk human papillomavirus (HR-HPV) in adult participants within England, and to explore any association with oral mucosal buccal epithelial cell and whole blood folate concentration.DESIGN: This was an observational study to determine oral HR-HPV prevalence in the study population. A case-control study was performed to explore the association between infection and folate status.SETTING: This study was conducted in Sheffield, UK, between April 2013 and August 2014.PARTICIPANTS: Seven hundred participants, aged 18-60 years, were recruited from university students (n=179), university and hospital staff (n=163), dental hospital patients (n=13), Sexual Health Sheffield patients (n=122) and the general public (n=223).INTERVENTIONS: Participants completed a lifestyle and sexual behaviour questionnaire, provided an oral rinse and gargle sample for the detection of oral HR-HPV and an oral mucosal buccal epithelial cell sample for the measurement of oral mucosal buccal epithelial cell folate. A blood sample was collected for measurement of whole blood folate concentration.OUTCOME MEASURES: The prevalence of oral HR-HPV infection in the study population was the primary outcome measure. Secondary outcome measures included associations between risk factors, folate status and infection.RESULTS: The prevalence of oral HR-HPV infection in this cohort was 2.2% (15/680) with 0.7% (5/680) positive for HPV16 or HPV18. Twenty samples were excluded due to insufficient material for HPV detection. Participants with oral HR-HPV infection were more likely to be a former smoker, and have a greater number of sexual and oral sexual partners. Folate status was not linked to likelihood of HPV infection.CONCLUSIONS: The prevalence of oral infection with HR-HPV in adult men and women in Sheffield in the North of England was low. Smoking and sexual behaviour were associated with HR-HPV positivity.TRIAL REGISTRATION NUMBER: ID14106.

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DO - 10.1136/bmjopen-2018-022497

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VL - 8

JO - BMJ Open

JF - BMJ Open

SN - 2044-6055

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