Oriented attachment of VNAR proteins, Q2 via site-selective modification, on PLGA–PEG nanoparticles enhances nanoconjugate performance

Joao C. F. Nogueira, Michelle K. Greene, Daniel A. Richards, Alexander O. Furby, John Steven, Andrew Porter, Caroline Barelle (Corresponding Author), Christopher J. Scott (Corresponding Author), Vijay Chudasama (Corresponding Author)

Research output: Contribution to journalArticle

Abstract

Herein we report the construction of a nanoparticle-based drug delivery system which targets a key regulator in tumour angiogenesis. We exploit a Variable New Antigen Receptor (VNAR) domain, conjugated using site-specific chemistry, to direct poly lactic acidco-glycolic acid–polyethylene glycol (PLGA–PEG) nanoparticles to delta like canonical Notch ligand 4 (DLL4). The importance of sitespecific chemistry is demonstrated.
Original languageEnglish
Pages (from-to)7671-7674
Number of pages4
JournalChemical Communications
Volume55
Issue number53
Early online date29 May 2019
DOIs
Publication statusPublished - 7 Jul 2019

Fingerprint

Nanoconjugates
Antigen Receptors
Glycols
Antigens
Nanoparticles
Proteins
Tumors
Ligands
Milk

Keywords

  • MONOCLONAL-ANTIBODY
  • TARGETED DELIVERY
  • FRAGMENTS
  • OPTIMIZATION
  • INSTALLATION
  • CONJUGATION
  • DRUGS

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Chemistry(all)
  • Catalysis

Cite this

Oriented attachment of VNAR proteins, Q2 via site-selective modification, on PLGA–PEG nanoparticles enhances nanoconjugate performance. / Nogueira, Joao C. F.; Greene, Michelle K.; Richards, Daniel A.; Furby, Alexander O.; Steven, John; Porter, Andrew; Barelle, Caroline (Corresponding Author); Scott, Christopher J. (Corresponding Author); Chudasama, Vijay (Corresponding Author).

In: Chemical Communications, Vol. 55, No. 53, 07.07.2019, p. 7671-7674.

Research output: Contribution to journalArticle

Nogueira, JCF, Greene, MK, Richards, DA, Furby, AO, Steven, J, Porter, A, Barelle, C, Scott, CJ & Chudasama, V 2019, 'Oriented attachment of VNAR proteins, Q2 via site-selective modification, on PLGA–PEG nanoparticles enhances nanoconjugate performance', Chemical Communications, vol. 55, no. 53, pp. 7671-7674. https://doi.org/10.1039/c9cc02655j
Nogueira, Joao C. F. ; Greene, Michelle K. ; Richards, Daniel A. ; Furby, Alexander O. ; Steven, John ; Porter, Andrew ; Barelle, Caroline ; Scott, Christopher J. ; Chudasama, Vijay. / Oriented attachment of VNAR proteins, Q2 via site-selective modification, on PLGA–PEG nanoparticles enhances nanoconjugate performance. In: Chemical Communications. 2019 ; Vol. 55, No. 53. pp. 7671-7674.
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