@article{3043494fa3ff463aa322d36feee63e07,
title = "Oriented attachment of VNAR proteins, Q2 via site-selective modification, on PLGA–PEG nanoparticles enhances nanoconjugate performance",
abstract = "Herein we report the construction of a nanoparticle-based drug delivery system which targets a key regulator in tumour angiogenesis. We exploit a Variable New Antigen Receptor (VNAR) domain, conjugated using site-specific chemistry, to direct poly lactic acidco-glycolic acid–polyethylene glycol (PLGA–PEG) nanoparticles to delta like canonical Notch ligand 4 (DLL4). The importance of sitespecific chemistry is demonstrated.",
keywords = "MONOCLONAL-ANTIBODY, TARGETED DELIVERY, FRAGMENTS, OPTIMIZATION, INSTALLATION, CONJUGATION, DRUGS",
author = "Nogueira, {Joao C. F.} and Greene, {Michelle K.} and Richards, {Daniel A.} and Furby, {Alexander O.} and John Steven and Andrew Porter and Caroline Barelle and Scott, {Christopher J.} and Vijay Chudasama",
note = "This work was partially funded through a US-Ireland R&D Partnership grant (STL/5010/14, MRC grant MC_PC_15013). JCFN is funded by the EU{\textquoteright}s Horizon 2020 programme under Marie-Curie grant agreement 675007. We acknowledge UCL Chemistry Mass Spectrometry Facility (Dr K. Karu/Dr X. Yang).",
year = "2019",
month = jul,
day = "7",
doi = "10.1039/c9cc02655j",
language = "English",
volume = "55",
pages = "7671--7674",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "53",
}