Osteoblast response to single wall carbon nanotube-PLLA composites

B. Annaz; B. Reid; B. Olalde; M. J. Jurado; J. I. Alava; C. D. McCaig; I. R. Gibson

Osteoblast response to single wall carbon nanotube-PLLA composites

B. Annaz^*, B. Reid, B. Olalde, M. J. Jurado, J. I. Alava, C. D. McCaig, I. R. Gibson

^*Corresponding author for this work

Medical Sciences

INASMET-Tecnalia

Research output: Chapter in Book/Report/Conference proceeding › Published conference contribution

Abstract

This study showed that incorporation of single-walled carbon nanotubes (1wt%) in to PLLA polymer resulted in a large decrease in resistivity, but did not appear to affect the growth and viability of osteoblast-like cells. Also, incorporation of SWCNTs resulted in no significant difference in alkaline phosphatase activity, an important early-stage marker of osteogenic differentiation, of BMSC. These initial studies suggest that SWCNTs did not have a negative effect on cell behaviour, compared to results reported for MWCNT [2]; this could be related to the purity of CNTs used in the present study. Further, long term studies are required to determine if there is a toxic response to the SWCNTs as the PLLA degrades.

Original language	English
Title of host publication	8th World Biomaterials Congress 2008
Number of pages	1
Volume	2
Publication status	Published - 1 Dec 2008
Event	8th World Biomaterials Congress 2008, WBC 2008 - Amsterdam, Netherlands Duration: 28 May 2008 → 1 Jun 2008

Conference

Conference	8th World Biomaterials Congress 2008, WBC 2008
Country/Territory	Netherlands
City	Amsterdam
Period	28/05/08 → 1/06/08

Cite this

@inproceedings{7e2777fee8b54b6fb87ffdfedfbdb66a,

title = "Osteoblast response to single wall carbon nanotube-PLLA composites",

abstract = "This study showed that incorporation of single-walled carbon nanotubes (1wt%) in to PLLA polymer resulted in a large decrease in resistivity, but did not appear to affect the growth and viability of osteoblast-like cells. Also, incorporation of SWCNTs resulted in no significant difference in alkaline phosphatase activity, an important early-stage marker of osteogenic differentiation, of BMSC. These initial studies suggest that SWCNTs did not have a negative effect on cell behaviour, compared to results reported for MWCNT [2]; this could be related to the purity of CNTs used in the present study. Further, long term studies are required to determine if there is a toxic response to the SWCNTs as the PLLA degrades.",

author = "B. Annaz and B. Reid and B. Olalde and Jurado, {M. J.} and Alava, {J. I.} and McCaig, {C. D.} and Gibson, {I. R.}",

year = "2008",

month = dec,

day = "1",

language = "English",

isbn = "9781615670802",

volume = "2",

booktitle = "8th World Biomaterials Congress 2008",

note = "8th World Biomaterials Congress 2008, WBC 2008 ; Conference date: 28-05-2008 Through 01-06-2008",

}

TY - GEN

T1 - Osteoblast response to single wall carbon nanotube-PLLA composites

AU - Annaz, B.

AU - Reid, B.

AU - Olalde, B.

AU - Jurado, M. J.

AU - Alava, J. I.

AU - McCaig, C. D.

AU - Gibson, I. R.

PY - 2008/12/1

Y1 - 2008/12/1

N2 - This study showed that incorporation of single-walled carbon nanotubes (1wt%) in to PLLA polymer resulted in a large decrease in resistivity, but did not appear to affect the growth and viability of osteoblast-like cells. Also, incorporation of SWCNTs resulted in no significant difference in alkaline phosphatase activity, an important early-stage marker of osteogenic differentiation, of BMSC. These initial studies suggest that SWCNTs did not have a negative effect on cell behaviour, compared to results reported for MWCNT [2]; this could be related to the purity of CNTs used in the present study. Further, long term studies are required to determine if there is a toxic response to the SWCNTs as the PLLA degrades.

AB - This study showed that incorporation of single-walled carbon nanotubes (1wt%) in to PLLA polymer resulted in a large decrease in resistivity, but did not appear to affect the growth and viability of osteoblast-like cells. Also, incorporation of SWCNTs resulted in no significant difference in alkaline phosphatase activity, an important early-stage marker of osteogenic differentiation, of BMSC. These initial studies suggest that SWCNTs did not have a negative effect on cell behaviour, compared to results reported for MWCNT [2]; this could be related to the purity of CNTs used in the present study. Further, long term studies are required to determine if there is a toxic response to the SWCNTs as the PLLA degrades.

UR - http://www.scopus.com/inward/record.url?scp=84869019451&partnerID=8YFLogxK

M3 - Published conference contribution

AN - SCOPUS:84869019451

SN - 9781615670802

VL - 2

BT - 8th World Biomaterials Congress 2008

T2 - 8th World Biomaterials Congress 2008, WBC 2008

Y2 - 28 May 2008 through 1 June 2008

ER -

Osteoblast response to single wall carbon nanotube-PLLA composites

Abstract

Conference

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