Osteoclast diseases and dental abnormalities

M H Helfrich

Research output: Contribution to journalLiterature review

57 Citations (Scopus)


Tooth eruption depends on the presence of osteoclasts to create an eruption pathway through the alveolar bone. In diseases where osteoclast formation, or function is reduced, such as the various types of osteopetrosis, tooth eruption is affected. Diseases in which osteoclast formation or activity is increased, such as familiar expansile osteotysis and Paget's disease, are associated with dental abnormatities such as root resorption and premature tooth toss. Less is known about the origin of the dental problems in these conditions as there are no rodent models of these diseases as yet. In this short review, the genes currently known to be mutated in human osteoclast diseases will be reviewed and, where known, the effect of osteoclast dysfunction on dental development described. It will focus on human conditions and only mention rodent disease where no clear data in the human are available. (c) 2004 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)115-122
Number of pages8
JournalArchives of Oral Biology
Issue number2
Early online date18 Jan 2005
Publication statusPublished - Feb 2005


  • osteoclast
  • osteopetrosis
  • tooth eruption
  • Paget's disease
  • pycnodysostosis
  • familiar expansile osteolysis
  • expansile skeletal
  • hyperphosphatasia
  • RANK
  • OPG
  • sequestosome-1
  • autosomal recessive osteoperosis
  • malignant infantile osteoperosis
  • bone-marrow transplantation
  • anhydrase-II deficiency
  • cathepsin-K deficiency
  • renal tubular-acidosis
  • Paget's-Disease
  • knockout mice
  • OP/OP mice


Dive into the research topics of 'Osteoclast diseases and dental abnormalities'. Together they form a unique fingerprint.

Cite this