Outdoor air pollution is associated with rapid decline of lung function in α-1-antitrypsin deficiency

Alice M Wood, Roy M Harrison, Sean Semple, Jon G Ayres, Robert A Stockley

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Introduction Outdoor air pollutants are associated with respiratory morbidity and mortality, but little longitudinal work has been undertaken in this area in chronic obstructive pulmonary disease (COPD). Patients with α-1-antitrypsin deficiency (AATD) typically exhibit faster decline of lung function than subjects with usual COPD and thus represent a group in whom studies of factors influencing decline may be more easily clarified. Methods Decline of FEV1 and KCO in subjects of the PiZZ genotype from the UK AATD registry were studied. Pollution levels (PM10, ozone, sulphur dioxide, nitrogen dioxide) during the exposure window were extracted from GIS maps, matching the measurement to each patient's home address. Clinical predictors of decline were sought using generalised estimating equations, and pollutants added to these subsequently. Single pollutant models were used due to multicollinearity. Results In the FEV1 decline analysis, higher baseline FEV1 was associated with rapid decline of FEV1 (p<0.001). High PM10 exposure predicted more rapid decline of FEV1 (p=0.024). In a similar analysis for KCO decline, higher baseline KCO predicted rapid decline (p<0.001) as did higher exposure to ozone (p=0.018). High PM10 exposure also showed a trend towards this effect (p=0.056).
Original languageEnglish
Pages (from-to)556-561
Number of pages6
JournalOccupational and Environmental Medicine
Volume67
Issue number8
DOIs
Publication statusPublished - Aug 2010

Fingerprint

Ozone
Air Pollution
Chronic Obstructive Pulmonary Disease
Nitrogen Dioxide
Sulfur Dioxide
Lung
Air Pollutants
Registries
Genotype
Morbidity
Mortality

Keywords

  • air Pollution
  • female
  • forced expiratory volume
  • Great Britain
  • humans
  • male
  • middle aged
  • occupational exposure
  • ozone
  • pulmonary disease, chronic obstructive
  • questionnaires
  • respiratory function tests
  • sulfur dioxide
  • alpha 1-antitrypsin deficiency

Cite this

Outdoor air pollution is associated with rapid decline of lung function in α-1-antitrypsin deficiency. / Wood, Alice M; Harrison, Roy M; Semple, Sean; Ayres, Jon G; Stockley, Robert A.

In: Occupational and Environmental Medicine, Vol. 67, No. 8, 08.2010, p. 556-561.

Research output: Contribution to journalArticle

Wood, Alice M ; Harrison, Roy M ; Semple, Sean ; Ayres, Jon G ; Stockley, Robert A. / Outdoor air pollution is associated with rapid decline of lung function in α-1-antitrypsin deficiency. In: Occupational and Environmental Medicine. 2010 ; Vol. 67, No. 8. pp. 556-561.
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