Overnourishing pregnant adolescent ewes stimulates perirenal fat deposition in their growth restricted foetuses

M Matsuzaki, John Milne, Raymond Aitken, D A Redmer, Jacqueline Wallace

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The influence of maternal nutrition during pregnancy on foetal adipose tissue development was studied in a sheep model of foetal growth restriction, achieved by overnourishing adolescent ewes. At Day 130 of gestation, the growth restricted foetuses from the overnourished rapidly growing dams (H) had higher perirenal fat proportions compared to control foetuses from the moderately fed adolescent dams (M). The mRNA expression for uncoupling protein (UCP)1 and leptin in foetal perirenal fat was equivalent between groups, but irrespective of maternal nutrition UCP1 was negatively correlated with foetal weight. Maternal plasma prolactin and glucose concentrations were higher in the H group and were positively associated with foetal perirenal fat deposition.

Original languageEnglish
Pages (from-to)519-522
Number of pages4
JournalJournal of Animal and Feed Sciences
Issue numberSuppl. 1
Publication statusPublished - 2004
Event10th International Symposium on Ruminant Pysiology - Copenhagen, Denmark
Duration: 30 Aug 20044 Sep 2004


  • adolescent pregnancy
  • foetal fat deposition
  • foetal growth
  • nutrition
  • prolactin
  • uncoupling protein 1
  • fetal

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