Abstract
The influence of maternal nutrition during pregnancy on foetal adipose tissue development was studied in a sheep model of foetal growth restriction, achieved by overnourishing adolescent ewes. At Day 130 of gestation, the growth restricted foetuses from the overnourished rapidly growing dams (H) had higher perirenal fat proportions compared to control foetuses from the moderately fed adolescent dams (M). The mRNA expression for uncoupling protein (UCP)1 and leptin in foetal perirenal fat was equivalent between groups, but irrespective of maternal nutrition UCP1 was negatively correlated with foetal weight. Maternal plasma prolactin and glucose concentrations were higher in the H group and were positively associated with foetal perirenal fat deposition.
| Original language | English |
|---|---|
| Pages (from-to) | 519-522 |
| Number of pages | 4 |
| Journal | Journal of Animal and Feed Sciences |
| Volume | 13 |
| Issue number | Suppl. 1 |
| Publication status | Published - 2004 |
| Event | 10th International Symposium on Ruminant Pysiology - Copenhagen, Denmark Duration: 30 Aug 2004 → 4 Sep 2004 |
Keywords
- adolescent pregnancy
- foetal fat deposition
- foetal growth
- nutrition
- prolactin
- uncoupling protein 1
- fetal
Cite this
Overnourishing pregnant adolescent ewes stimulates perirenal fat deposition in their growth restricted foetuses. / Matsuzaki, M ; Milne, John; Aitken, Raymond; Redmer, D A ; Wallace, Jacqueline.
In: Journal of Animal and Feed Sciences, Vol. 13, No. Suppl. 1, 2004, p. 519-522.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Overnourishing pregnant adolescent ewes stimulates perirenal fat deposition in their growth restricted foetuses
AU - Matsuzaki, M
AU - Milne, John
AU - Aitken, Raymond
AU - Redmer, D A
AU - Wallace, Jacqueline
PY - 2004
Y1 - 2004
N2 - The influence of maternal nutrition during pregnancy on foetal adipose tissue development was studied in a sheep model of foetal growth restriction, achieved by overnourishing adolescent ewes. At Day 130 of gestation, the growth restricted foetuses from the overnourished rapidly growing dams (H) had higher perirenal fat proportions compared to control foetuses from the moderately fed adolescent dams (M). The mRNA expression for uncoupling protein (UCP)1 and leptin in foetal perirenal fat was equivalent between groups, but irrespective of maternal nutrition UCP1 was negatively correlated with foetal weight. Maternal plasma prolactin and glucose concentrations were higher in the H group and were positively associated with foetal perirenal fat deposition.
AB - The influence of maternal nutrition during pregnancy on foetal adipose tissue development was studied in a sheep model of foetal growth restriction, achieved by overnourishing adolescent ewes. At Day 130 of gestation, the growth restricted foetuses from the overnourished rapidly growing dams (H) had higher perirenal fat proportions compared to control foetuses from the moderately fed adolescent dams (M). The mRNA expression for uncoupling protein (UCP)1 and leptin in foetal perirenal fat was equivalent between groups, but irrespective of maternal nutrition UCP1 was negatively correlated with foetal weight. Maternal plasma prolactin and glucose concentrations were higher in the H group and were positively associated with foetal perirenal fat deposition.
KW - adolescent pregnancy
KW - foetal fat deposition
KW - foetal growth
KW - nutrition
KW - prolactin
KW - uncoupling protein 1
KW - fetal
M3 - Article
VL - 13
SP - 519
EP - 522
JO - Journal of Animal and Feed Sciences
JF - Journal of Animal and Feed Sciences
SN - 1230-1388
IS - Suppl. 1
ER -