Oxidative damage, ageing, and life-history evolution

Where now?

Colin Selman*, Jonathan D. Blount, Daniel H. Nussey, John R. Speakman

*Corresponding author for this work

Research output: Contribution to journalReview article

185 Citations (Scopus)

Abstract

The idea that resources are limited and animals can maximise fitness by trading costly activities off against one another forms the basis of life-history theory. Although investment in reproduction or growth negatively affects survival, the mechanisms underlying such trade-offs remain obscure. One plausible mechanism is oxidative damage to proteins, lipids, and nucleic acids caused by reactive oxygen species (ROS). Here, we critically evaluate the premise that ROS-induced oxidative damage shapes life history, focussing on birds and mammals, and highlight the importance of ecological studies examining free-living animals within this experimental framework. We conclude by emphasising the value of using multiple assays to determine oxidative protection and damage. We also highlight the importance of using standardised and appropriate protocols, and discuss future research directions.

Original languageEnglish
Pages (from-to)570-577
Number of pages8
JournalTrends in Ecology and Evolution
Volume27
Issue number10
Early online date11 Jul 2012
DOIs
Publication statusPublished - 1 Oct 2012

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reactive oxygen species
life history
damage
nucleic acids
life history theory
animals
animal
nucleic acid
mammals
birds
assays
fitness
mammal
lipids
lipid
assay
bird
protein
proteins
resource

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics

Cite this

Oxidative damage, ageing, and life-history evolution : Where now? / Selman, Colin; Blount, Jonathan D.; Nussey, Daniel H.; Speakman, John R.

In: Trends in Ecology and Evolution, Vol. 27, No. 10, 01.10.2012, p. 570-577.

Research output: Contribution to journalReview article

Selman, Colin ; Blount, Jonathan D. ; Nussey, Daniel H. ; Speakman, John R. / Oxidative damage, ageing, and life-history evolution : Where now?. In: Trends in Ecology and Evolution. 2012 ; Vol. 27, No. 10. pp. 570-577.
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