Oxidative damage increases with reproductive energy expenditure and is reduced by food-supplementation

Quinn E. Fletcher*, Colin Selman, Stan Boutin, Andrew G. McAdam, Sarah B. Woods, Arnold Y. Seo, Christiaan Leeuwenburgh, John R. Speakman, Murray M. Humphries

*Corresponding author for this work

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

A central principle in life-history theory is that reproductive effort negatively affects survival. Costs of reproduction are thought to be physiologically based, but the underlying mechanisms remain poorly understood. Using female North American red squirrels (Tamiasciurus hudsonicus), we test the hypothesis that energetic investment in reproduction overwhelms investment in antioxidant protection, leading to oxidative damage. In support of this hypothesis we found that the highest levels of plasma protein oxidative damage in squirrels occurred during the energetically demanding period of lactation. Moreover, plasma protein oxidative damage was also elevated in squirrels that expended the most energy and had the lowest antioxidant protection. Finally, we found that squirrels that were food-supplemented during lactation and winter had increased antioxidant protection and reduced plasma protein oxidative damage providing the first experimental evidence in the wild that access to abundant resources can reduce this physiological cost.

Original languageEnglish
Pages (from-to)1527-1536
Number of pages10
JournalEvolution
Volume67
Issue number5
Early online date20 Dec 2012
DOIs
Publication statusPublished - May 2013

Keywords

  • Antioxidant protection
  • Daily energy expenditure
  • Doubly-labeled water
  • Energetics
  • Food-supplementation
  • Life-history theory

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Agricultural and Biological Sciences(all)

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    Fletcher, Q. E., Selman, C., Boutin, S., McAdam, A. G., Woods, S. B., Seo, A. Y., Leeuwenburgh, C., Speakman, J. R., & Humphries, M. M. (2013). Oxidative damage increases with reproductive energy expenditure and is reduced by food-supplementation. Evolution, 67(5), 1527-1536. https://doi.org/10.1111/evo.12014