Oxidative stress in colon tissue induced by vitamin E depletion

J. E. Drew, D. K. Mercer, C. Mayer, A. J. Farquharson, P. C. Morrice, J. R. Arthur, G. G. Duthie

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Inflammatory disorders of the bowel and colon cancer are associated with elevated indices of oxidative stress. Analogous elevations in markers of oxidative stress and loss of cell-membrane integrity are also observed in the colons of rats deficient in vitamin E (D-alpha-tocopherol), the major lipid-soluble antioxidant in biological systems. The causal relationship between colon pathologies associated with oxidative stress and dietary deficiency in antioxidant vitamins such as vitamin E is still uncertain. Investigation of potential mechanisms by which lack of dietary vitamin E may lead to clinically relevant pathological changes in colon tissue was conducted using gene expression profiling strategies on vitamin E-sufficient and -deficient rats. Morphological changes and increased indices of lipid peroxidation were linked to vitamin E deficiency. These changes in colon tissue are potentially important in disease pathogenesis of the colon linked with oxidative stress or other direct consequences of inadequate levels of vitamin E.
Original languageEnglish
Pages (from-to)979-981
Number of pages3
JournalBiochemical Society Transactions
Volume32
Issue number6
DOIs
Publication statusPublished - 1 Dec 2004

Keywords

  • animals
  • colon
  • gene expression regulation
  • lipid peroxidation
  • oxidative stress
  • rats
  • rats, inbred strains
  • vitamin E deficiency
  • alpha-tocopherol
  • collagen alpha(1)
  • colon tissue
  • lysyl oxidase deregulation
  • inflammatory bowel disease
  • collagenous colitis
  • gene expression
  • damage

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