Oxidative stress, malaria, sickle cell disease, and innate immunity

Huan Cao, Mark Vickers* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Plasmodium falciparum shields from adaptive immunity in erythrocytes, but how might the innate immune system recognize infected cells? Replication by the parasite results in oxidative stress, causing surface expression of high-mannose glycans. These can act as pathogen-associated molecular patterns to stimulate phagocytosis in the spleen and the sickle cell allele enhances these responses.
Original languageEnglish
JournalTrends in Immunology
Early online date7 Sep 2021
DOIs
Publication statusE-pub ahead of print - 7 Sep 2021

Keywords

  • malaria
  • sickle cell disease
  • oxidative stress
  • high mannose glycans
  • pathogen associated molecular patterns
  • damage associated molecular pattern
  • phagocytosis

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