Oxidative stress, malaria, sickle cell disease, and innate immunity

Huan Cao; Mark Vickers

doi:10.1016/j.it.2021.08.008

Oxidative stress, malaria, sickle cell disease, and innate immunity

Huan Cao, Mark Vickers^* (Corresponding Author)

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Plasmodium falciparum shields from adaptive immunity in erythrocytes, but how might the innate immune system recognize infected cells? Replication by the parasite results in oxidative stress, causing surface expression of high-mannose glycans. These can act as pathogen-associated molecular patterns to stimulate phagocytosis in the spleen and the sickle cell allele enhances these responses.

Original language	English
Pages (from-to)	849-851
Number of pages	3
Journal	Trends in Immunology
Volume	42
Issue number	10
Early online date	30 Sep 2021
DOIs	https://doi.org/10.1016/j.it.2021.08.008
Publication status	Published - 1 Dec 2021

Keywords

malaria
sickle cell disease
oxidative stress
high mannose glycans
pathogen associated molecular patterns
damage associated molecular pattern
phagocytosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.it.2021.08.008Licence: Unspecified

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© 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
Accepted author manuscript, 239 KBLicence: CC BY-NC-ND

Cite this

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title = "Oxidative stress, malaria, sickle cell disease, and innate immunity",

abstract = "Plasmodium falciparum shields from adaptive immunity in erythrocytes, but how might the innate immune system recognize infected cells? Replication by the parasite results in oxidative stress, causing surface expression of high-mannose glycans. These can act as pathogen-associated molecular patterns to stimulate phagocytosis in the spleen and the sickle cell allele enhances these responses.",

keywords = "malaria, sickle cell disease, oxidative stress, high mannose glycans, pathogen associated molecular patterns, damage associated molecular pattern, phagocytosis",

author = "Huan Cao and Mark Vickers",

note = "This work was supported by the Wellcome Trust (grant 094847).",

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AU - Cao, Huan

AU - Vickers, Mark

N1 - This work was supported by the Wellcome Trust (grant 094847).

PY - 2021/12/1

Y1 - 2021/12/1

N2 - Plasmodium falciparum shields from adaptive immunity in erythrocytes, but how might the innate immune system recognize infected cells? Replication by the parasite results in oxidative stress, causing surface expression of high-mannose glycans. These can act as pathogen-associated molecular patterns to stimulate phagocytosis in the spleen and the sickle cell allele enhances these responses.

AB - Plasmodium falciparum shields from adaptive immunity in erythrocytes, but how might the innate immune system recognize infected cells? Replication by the parasite results in oxidative stress, causing surface expression of high-mannose glycans. These can act as pathogen-associated molecular patterns to stimulate phagocytosis in the spleen and the sickle cell allele enhances these responses.

KW - malaria

KW - sickle cell disease

KW - oxidative stress

KW - high mannose glycans

KW - pathogen associated molecular patterns

KW - damage associated molecular pattern

KW - phagocytosis

U2 - 10.1016/j.it.2021.08.008

DO - 10.1016/j.it.2021.08.008

M3 - Article

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SP - 849

EP - 851

JO - Trends in Immunology

JF - Trends in Immunology

SN - 1471-4906

IS - 10

ER -

Oxidative stress, malaria, sickle cell disease, and innate immunity

Abstract

Keywords

UN SDGs

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