Oxytocin is implicated in social memory deficits induced by early sensory deprivation in mice

Jin-Bao Zhang, Ling Chen, Zhu-Man Lv, Xue-Yuan Niu, Can-Can Shao, Chan Zhang, Michal Pruski, Ying Huang, Cong-Cong Qi, Ning-Ning Song, Bing Lang, Yu-Qiang Ding*

*Corresponding author for this work

Research output: Contribution to journalArticle

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Abstract

Early-life sensory input plays a crucial role in brain development. Although deprivation of orofacial sensory input at perinatal stages disrupts the establishment of the barrel cortex and relevant callosal connections, its long-term effect on adult behavior remains elusive. In this study, we investigated the behavioral phenotypes in adult mice with unilateral transection of the infraorbital nerve (ION) at postnatal day 3 (P3). Although ION-transected mice had normal locomotor activity, motor coordination, olfaction, anxiety-like behaviors, novel object memory, preference for social novelty and sociability, they presented deficits in social memory and spatial memory compared with control mice. In addition, the social memory deficit was associated with reduced oxytocin (OXT) levels in the hypothalamus and could be partially restored by intranasal administration of OXT. Thus, early sensory deprivation does result in behavioral alterations in mice, some of which may be associated with the disruption of oxytocin signaling.

Original languageEnglish
Article number98
Number of pages13
JournalMolecular brain
Volume9
DOIs
Publication statusPublished - 13 Dec 2016

Keywords

  • Sensory deprivation
  • Infraorbital nerve
  • Social memory
  • Oxytocin
  • Spatial memory
  • Autism
  • Mouse barrel cortex
  • autistic-like behavior
  • somatosensory cortex
  • early experience
  • split-brain
  • functional-organization
  • synaptic plasticity
  • vibrissal damage
  • medial amygdala
  • water-maze

Cite this

Zhang, J-B., Chen, L., Lv, Z-M., Niu, X-Y., Shao, C-C., Zhang, C., ... Ding, Y-Q. (2016). Oxytocin is implicated in social memory deficits induced by early sensory deprivation in mice. Molecular brain, 9, [98]. https://doi.org/10.1186/s13041-016-0278-3