Oxytocin is implicated in social memory deficits induced by early sensory deprivation in mice

Jin-Bao Zhang; Ling Chen; Zhu-Man Lv; Xue-Yuan Niu; Can-Can Shao; Chan Zhang; Michal Pruski; Ying Huang; Cong-Cong Qi; Ning-Ning Song; Bing Lang; Yu-Qiang Ding

doi:10.1186/s13041-016-0278-3

Oxytocin is implicated in social memory deficits induced by early sensory deprivation in mice

Jin-Bao Zhang, Ling Chen, Zhu-Man Lv, Xue-Yuan Niu, Can-Can Shao, Chan Zhang, Michal Pruski, Ying Huang, Cong-Cong Qi, Ning-Ning Song, Bing Lang, Yu-Qiang Ding^*

^*Corresponding author for this work

Medical Sciences

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Abstract

Early-life sensory input plays a crucial role in brain development. Although deprivation of orofacial sensory input at perinatal stages disrupts the establishment of the barrel cortex and relevant callosal connections, its long-term effect on adult behavior remains elusive. In this study, we investigated the behavioral phenotypes in adult mice with unilateral transection of the infraorbital nerve (ION) at postnatal day 3 (P3). Although ION-transected mice had normal locomotor activity, motor coordination, olfaction, anxiety-like behaviors, novel object memory, preference for social novelty and sociability, they presented deficits in social memory and spatial memory compared with control mice. In addition, the social memory deficit was associated with reduced oxytocin (OXT) levels in the hypothalamus and could be partially restored by intranasal administration of OXT. Thus, early sensory deprivation does result in behavioral alterations in mice, some of which may be associated with the disruption of oxytocin signaling.

Original language	English
Article number	98
Number of pages	13
Journal	Molecular brain
Volume	9
DOIs	https://doi.org/10.1186/s13041-016-0278-3
Publication status	Published - 13 Dec 2016

Bibliographical note

Acknowledgements
We thank Miss Jia-Yin and Miss Yu-Ling Sun for their help in breading the mice.

Funding
This work was supported by grants from the National Natural Science Foundation of China (81200933 to N.-N. Song; 81200692 to L. Chen; 81101026 to Y. Huang; 31528011 to B. Lang; 81221001, 91232724 and 81571332 to Y-Q. Ding), Zhejiang Province Natural Science Foundation of China (LQ13C090004 to C. Zhang), China Postdoctoral Science Foundation (2016 M591714 to C.-C. Qi), and the Fundamental Research Funds for the Central Universities (2013KJ049).

Keywords

Sensory deprivation
Infraorbital nerve
Social memory
Oxytocin
Spatial memory
Autism
Mouse barrel cortex
autistic-like behavior
somatosensory cortex
early experience
split-brain
functional-organization
synaptic plasticity
vibrissal damage
medial amygdala
water-maze

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Oxytocin is implicated in social memory
© The Author(s). 2016 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated
Final published version, 2.1 MBLicence: CC BY

Cite this

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title = "Oxytocin is implicated in social memory deficits induced by early sensory deprivation in mice",

abstract = "Early-life sensory input plays a crucial role in brain development. Although deprivation of orofacial sensory input at perinatal stages disrupts the establishment of the barrel cortex and relevant callosal connections, its long-term effect on adult behavior remains elusive. In this study, we investigated the behavioral phenotypes in adult mice with unilateral transection of the infraorbital nerve (ION) at postnatal day 3 (P3). Although ION-transected mice had normal locomotor activity, motor coordination, olfaction, anxiety-like behaviors, novel object memory, preference for social novelty and sociability, they presented deficits in social memory and spatial memory compared with control mice. In addition, the social memory deficit was associated with reduced oxytocin (OXT) levels in the hypothalamus and could be partially restored by intranasal administration of OXT. Thus, early sensory deprivation does result in behavioral alterations in mice, some of which may be associated with the disruption of oxytocin signaling.",

keywords = "Sensory deprivation, Infraorbital nerve, Social memory, Oxytocin, Spatial memory, Autism, Mouse barrel cortex, autistic-like behavior, somatosensory cortex, early experience, split-brain, functional-organization, synaptic plasticity, vibrissal damage, medial amygdala, water-maze",

author = "Jin-Bao Zhang and Ling Chen and Zhu-Man Lv and Xue-Yuan Niu and Can-Can Shao and Chan Zhang and Michal Pruski and Ying Huang and Cong-Cong Qi and Ning-Ning Song and Bing Lang and Yu-Qiang Ding",

note = "Acknowledgements We thank Miss Jia-Yin and Miss Yu-Ling Sun for their help in breading the mice. Funding This work was supported by grants from the National Natural Science Foundation of China (81200933 to N.-N. Song; 81200692 to L. Chen; 81101026 to Y. Huang; 31528011 to B. Lang; 81221001, 91232724 and 81571332 to Y-Q. Ding), Zhejiang Province Natural Science Foundation of China (LQ13C090004 to C. Zhang), China Postdoctoral Science Foundation (2016 M591714 to C.-C. Qi), and the Fundamental Research Funds for the Central Universities (2013KJ049). ",

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doi = "10.1186/s13041-016-0278-3",

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AU - Zhang, Jin-Bao

AU - Chen, Ling

AU - Lv, Zhu-Man

AU - Niu, Xue-Yuan

AU - Shao, Can-Can

AU - Zhang, Chan

AU - Pruski, Michal

AU - Huang, Ying

AU - Qi, Cong-Cong

AU - Song, Ning-Ning

AU - Lang, Bing

AU - Ding, Yu-Qiang

N1 - Acknowledgements We thank Miss Jia-Yin and Miss Yu-Ling Sun for their help in breading the mice. Funding This work was supported by grants from the National Natural Science Foundation of China (81200933 to N.-N. Song; 81200692 to L. Chen; 81101026 to Y. Huang; 31528011 to B. Lang; 81221001, 91232724 and 81571332 to Y-Q. Ding), Zhejiang Province Natural Science Foundation of China (LQ13C090004 to C. Zhang), China Postdoctoral Science Foundation (2016 M591714 to C.-C. Qi), and the Fundamental Research Funds for the Central Universities (2013KJ049).

PY - 2016/12/13

Y1 - 2016/12/13

N2 - Early-life sensory input plays a crucial role in brain development. Although deprivation of orofacial sensory input at perinatal stages disrupts the establishment of the barrel cortex and relevant callosal connections, its long-term effect on adult behavior remains elusive. In this study, we investigated the behavioral phenotypes in adult mice with unilateral transection of the infraorbital nerve (ION) at postnatal day 3 (P3). Although ION-transected mice had normal locomotor activity, motor coordination, olfaction, anxiety-like behaviors, novel object memory, preference for social novelty and sociability, they presented deficits in social memory and spatial memory compared with control mice. In addition, the social memory deficit was associated with reduced oxytocin (OXT) levels in the hypothalamus and could be partially restored by intranasal administration of OXT. Thus, early sensory deprivation does result in behavioral alterations in mice, some of which may be associated with the disruption of oxytocin signaling.

AB - Early-life sensory input plays a crucial role in brain development. Although deprivation of orofacial sensory input at perinatal stages disrupts the establishment of the barrel cortex and relevant callosal connections, its long-term effect on adult behavior remains elusive. In this study, we investigated the behavioral phenotypes in adult mice with unilateral transection of the infraorbital nerve (ION) at postnatal day 3 (P3). Although ION-transected mice had normal locomotor activity, motor coordination, olfaction, anxiety-like behaviors, novel object memory, preference for social novelty and sociability, they presented deficits in social memory and spatial memory compared with control mice. In addition, the social memory deficit was associated with reduced oxytocin (OXT) levels in the hypothalamus and could be partially restored by intranasal administration of OXT. Thus, early sensory deprivation does result in behavioral alterations in mice, some of which may be associated with the disruption of oxytocin signaling.

KW - Sensory deprivation

KW - Infraorbital nerve

KW - Social memory

KW - Oxytocin

KW - Spatial memory

KW - Autism

KW - Mouse barrel cortex

KW - autistic-like behavior

KW - somatosensory cortex

KW - early experience

KW - split-brain

KW - functional-organization

KW - synaptic plasticity

KW - vibrissal damage

KW - medial amygdala

KW - water-maze

U2 - 10.1186/s13041-016-0278-3

DO - 10.1186/s13041-016-0278-3

M3 - Article

SN - 1756-6606

VL - 9

JO - Molecular brain

JF - Molecular brain

M1 - 98

ER -

Oxytocin is implicated in social memory deficits induced by early sensory deprivation in mice

Abstract

Bibliographical note

Keywords

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