Pan-Domain Analysis of ZIP Zinc Transporters

Laura E. Lehtovirta-Morley; Mohammad Alsarraf; Duncan Wilson

doi:10.3390/ijms18122631

Pan-Domain Analysis of ZIP Zinc Transporters

Laura E. Lehtovirta-Morley, Mohammad Alsarraf, Duncan Wilson

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Abstract

The ZIP family of zinc transporters is found in all three domains of life. However, little is known about the phylogenetic relationship amongst ZIP transporters, their distribution or origin. Here we employed phylogenetic analysis to explore the evolution of ZIP transporters, with a focus on the major human fungal pathogen, Candida albicans. Pan-domain analysis of bacterial, archaeal, fungal and human proteins revealed a complex relationship amongst the ZIP family members. Here we report (i) a eukaryote-wide group of cellular zinc importers (ii) a fungal-specific group of zinc importers, with genetic association with the fungal zincophore, and, (iii) a pan-kingdom supercluster made up of two distinct subgroups with orthologues in bacterial, archaeal and eukaryotic phyla.

Original language	English
Article number	2631
Journal	International Journal of Molecular Sciences
Volume	18
Issue number	12
DOIs	https://doi.org/10.3390/ijms18122631
Publication status	Published - 6 Dec 2017

Bibliographical note

DW is supported by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (102549/Z/13/Z), a Wellcome Trust ISSF seed corn grant (RG12723 14), the Medical Research Council and University of Aberdeen (MR/N006364/1) and a Wellcome Trust Strategic Award for Medical Mycology and Fungal Immunology (097377/Z/11/Z). LL is supported by a Royal Society Dorothy Hodgkin Fellowship (DH150187). MA is funded by the Public Authority for Applied Education and Training, Kuwait.

Keywords

ZIP
zinc
transport
transporter
evolution
pathogenic fungi
Candida albicans

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10.3390/ijms18122631Licence: CC BY

Pan-Domain Analysis of ZIP Zinc Transporters
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0). https://creativecommons.org/licenses/by/4.0/
Final published version, 1.39 MBLicence: CC BY

Cite this

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abstract = "The ZIP family of zinc transporters is found in all three domains of life. However, little is known about the phylogenetic relationship amongst ZIP transporters, their distribution or origin. Here we employed phylogenetic analysis to explore the evolution of ZIP transporters, with a focus on the major human fungal pathogen, Candida albicans. Pan-domain analysis of bacterial, archaeal, fungal and human proteins revealed a complex relationship amongst the ZIP family members. Here we report (i) a eukaryote-wide group of cellular zinc importers (ii) a fungal-specific group of zinc importers, with genetic association with the fungal zincophore, and, (iii) a pan-kingdom supercluster made up of two distinct subgroups with orthologues in bacterial, archaeal and eukaryotic phyla.",

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AB - The ZIP family of zinc transporters is found in all three domains of life. However, little is known about the phylogenetic relationship amongst ZIP transporters, their distribution or origin. Here we employed phylogenetic analysis to explore the evolution of ZIP transporters, with a focus on the major human fungal pathogen, Candida albicans. Pan-domain analysis of bacterial, archaeal, fungal and human proteins revealed a complex relationship amongst the ZIP family members. Here we report (i) a eukaryote-wide group of cellular zinc importers (ii) a fungal-specific group of zinc importers, with genetic association with the fungal zincophore, and, (iii) a pan-kingdom supercluster made up of two distinct subgroups with orthologues in bacterial, archaeal and eukaryotic phyla.

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Pan-Domain Analysis of ZIP Zinc Transporters

Abstract

Bibliographical note

Keywords

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