Pan-Domain Analysis of ZIP Zinc Transporters

Laura E. Lehtovirta-Morley, Mohammad Alsarraf, Duncan Wilson

Research output: Contribution to journalArticle

3 Citations (Scopus)
7 Downloads (Pure)

Abstract

The ZIP family of zinc transporters is found in all three domains of life. However, little is known about the phylogenetic relationship amongst ZIP transporters, their distribution or origin. Here we employed phylogenetic analysis to explore the evolution of ZIP transporters, with a focus on the major human fungal pathogen, Candida albicans. Pan-domain analysis of bacterial, archaeal, fungal and human proteins revealed a complex relationship amongst the ZIP family members. Here we report (i) a eukaryote-wide group of cellular zinc importers (ii) a fungal-specific group of zinc importers, with genetic association with the fungal zincophore, and, (iii) a pan-kingdom supercluster made up of two distinct subgroups with orthologues in bacterial, archaeal and eukaryotic phyla.
Original languageEnglish
Article number2631
Journal International Journal of Molecular Sciences
Volume18
Issue number12
DOIs
Publication statusPublished - 6 Dec 2017

Fingerprint

transporter
Zinc
zinc
Fungal Proteins
Candida
Pathogens
Eukaryota
Candida albicans
eukaryotes
pathogens
subgroups
proteins
Proteins
zinc-binding protein

Keywords

  • ZIP
  • zinc
  • transport
  • transporter
  • evolution
  • pathogenic fungi
  • Candida albicans

Cite this

Pan-Domain Analysis of ZIP Zinc Transporters. / Lehtovirta-Morley, Laura E.; Alsarraf, Mohammad; Wilson, Duncan.

In: International Journal of Molecular Sciences, Vol. 18, No. 12, 2631, 06.12.2017.

Research output: Contribution to journalArticle

Lehtovirta-Morley, Laura E. ; Alsarraf, Mohammad ; Wilson, Duncan. / Pan-Domain Analysis of ZIP Zinc Transporters. In: International Journal of Molecular Sciences. 2017 ; Vol. 18, No. 12.
@article{0c8563137f3d451f8728266e62ee4974,
title = "Pan-Domain Analysis of ZIP Zinc Transporters",
abstract = "The ZIP family of zinc transporters is found in all three domains of life. However, little is known about the phylogenetic relationship amongst ZIP transporters, their distribution or origin. Here we employed phylogenetic analysis to explore the evolution of ZIP transporters, with a focus on the major human fungal pathogen, Candida albicans. Pan-domain analysis of bacterial, archaeal, fungal and human proteins revealed a complex relationship amongst the ZIP family members. Here we report (i) a eukaryote-wide group of cellular zinc importers (ii) a fungal-specific group of zinc importers, with genetic association with the fungal zincophore, and, (iii) a pan-kingdom supercluster made up of two distinct subgroups with orthologues in bacterial, archaeal and eukaryotic phyla.",
keywords = "ZIP, zinc, transport, transporter, evolution, pathogenic fungi, Candida albicans",
author = "Lehtovirta-Morley, {Laura E.} and Mohammad Alsarraf and Duncan Wilson",
note = "DW is supported by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (102549/Z/13/Z), a Wellcome Trust ISSF seed corn grant (RG12723 14), the Medical Research Council and University of Aberdeen (MR/N006364/1) and a Wellcome Trust Strategic Award for Medical Mycology and Fungal Immunology (097377/Z/11/Z). LL is supported by a Royal Society Dorothy Hodgkin Fellowship (DH150187). MA is funded by the Public Authority for Applied Education and Training, Kuwait.",
year = "2017",
month = "12",
day = "6",
doi = "10.3390/ijms18122631",
language = "English",
volume = "18",
journal = "International Journal of Molecular Sciences",
issn = "1422-0067",
publisher = "MDPI",
number = "12",

}

TY - JOUR

T1 - Pan-Domain Analysis of ZIP Zinc Transporters

AU - Lehtovirta-Morley, Laura E.

AU - Alsarraf, Mohammad

AU - Wilson, Duncan

N1 - DW is supported by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (102549/Z/13/Z), a Wellcome Trust ISSF seed corn grant (RG12723 14), the Medical Research Council and University of Aberdeen (MR/N006364/1) and a Wellcome Trust Strategic Award for Medical Mycology and Fungal Immunology (097377/Z/11/Z). LL is supported by a Royal Society Dorothy Hodgkin Fellowship (DH150187). MA is funded by the Public Authority for Applied Education and Training, Kuwait.

PY - 2017/12/6

Y1 - 2017/12/6

N2 - The ZIP family of zinc transporters is found in all three domains of life. However, little is known about the phylogenetic relationship amongst ZIP transporters, their distribution or origin. Here we employed phylogenetic analysis to explore the evolution of ZIP transporters, with a focus on the major human fungal pathogen, Candida albicans. Pan-domain analysis of bacterial, archaeal, fungal and human proteins revealed a complex relationship amongst the ZIP family members. Here we report (i) a eukaryote-wide group of cellular zinc importers (ii) a fungal-specific group of zinc importers, with genetic association with the fungal zincophore, and, (iii) a pan-kingdom supercluster made up of two distinct subgroups with orthologues in bacterial, archaeal and eukaryotic phyla.

AB - The ZIP family of zinc transporters is found in all three domains of life. However, little is known about the phylogenetic relationship amongst ZIP transporters, their distribution or origin. Here we employed phylogenetic analysis to explore the evolution of ZIP transporters, with a focus on the major human fungal pathogen, Candida albicans. Pan-domain analysis of bacterial, archaeal, fungal and human proteins revealed a complex relationship amongst the ZIP family members. Here we report (i) a eukaryote-wide group of cellular zinc importers (ii) a fungal-specific group of zinc importers, with genetic association with the fungal zincophore, and, (iii) a pan-kingdom supercluster made up of two distinct subgroups with orthologues in bacterial, archaeal and eukaryotic phyla.

KW - ZIP

KW - zinc

KW - transport

KW - transporter

KW - evolution

KW - pathogenic fungi

KW - Candida albicans

U2 - 10.3390/ijms18122631

DO - 10.3390/ijms18122631

M3 - Article

VL - 18

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1422-0067

IS - 12

M1 - 2631

ER -