Panton–Valentine leukocidin-positive Staphylococcus aureus: a position statement from the International Society of Chemotherapy

Kordo Saeed, Ian Gould, Silvano Espositio, Nusreen Ahmad-Saeed, Salman Shaheer Ahmed, Emine Alp, Abhijit M. Bal, Matteo Bassetti, Eric Bonnet, Monica Chan, Geoffrey Coombs, Stephanie Dancer, Michael Z. David, Giuseppe De Simone, Matthew Dryden, Luca Guardabassi, Leif G. Hanitsch, Karolin Hijazi, Renate Krüger, Andie LeeRasmus Leistner, Pasquale Pagliano, Elda Righi, Sylke Schneider-Burrus, Robert Leo Skov, Pierre Tattevin, Willem Van Wamel, Margreet C. Vos, Andreas Voss, International Society of Chemotherapy

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Abstract

Panton–Valentine leukocidin (PVL), a pore-forming cytotoxic secreted toxin, has been associated with severe Staphylococcus aureus pneumonia and prototypical skin lesions. The reported incidence and prevalence of PVL-positive S. aureus (PVLP-SA) varies globally and suffers from a selective reporting bias towards community-associated methicillin-resistant S. aureus (CA-MRSA). Recent studies, however, have identified PVL-positive methicillin-susceptible S. aureus (MSSA) more frequently than previously expected. In this review, a group of experts from four continents affiliated with the International Society of Chemotherapy (ISC) offer a position statement on the important aspects of PVL in S. aureus epidemiology, antimicrobial treatment and decolonisation, and aim to highlight future areas for collaboration and research.
Original languageEnglish
Pages (from-to)16-25
Number of pages10
JournalInternational Journal of Antimicrobial Agents
Volume51
Issue number1
Early online date22 Nov 2017
DOIs
Publication statusPublished - Jan 2018

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Leukocidins
Staphylococcus aureus
Drug Therapy
Staphylococcal Pneumonia
Methicillin
Methicillin-Resistant Staphylococcus aureus
Epidemiology
Skin
Incidence
Research

Keywords

  • PVL
  • CA-MRSA
  • MSSA
  • S. aureus
  • infection control

Cite this

Panton–Valentine leukocidin-positive Staphylococcus aureus: a position statement from the International Society of Chemotherapy. / Saeed, Kordo; Gould, Ian; Espositio, Silvano; Ahmad-Saeed, Nusreen; Ahmed, Salman Shaheer; Alp, Emine; Bal, Abhijit M.; Bassetti, Matteo; Bonnet, Eric; Chan, Monica; Coombs, Geoffrey; Dancer, Stephanie; David, Michael Z.; De Simone, Giuseppe; Dryden, Matthew; Guardabassi, Luca; Hanitsch, Leif G.; Hijazi, Karolin; Krüger, Renate; Lee, Andie; Leistner, Rasmus; Pagliano, Pasquale; Righi, Elda; Schneider-Burrus, Sylke; Skov, Robert Leo; Tattevin, Pierre; Van Wamel, Willem; Vos, Margreet C.; Voss, Andreas; International Society of Chemotherapy.

In: International Journal of Antimicrobial Agents, Vol. 51, No. 1, 01.2018, p. 16-25.

Research output: Contribution to journalArticle

Saeed, K, Gould, I, Espositio, S, Ahmad-Saeed, N, Ahmed, SS, Alp, E, Bal, AM, Bassetti, M, Bonnet, E, Chan, M, Coombs, G, Dancer, S, David, MZ, De Simone, G, Dryden, M, Guardabassi, L, Hanitsch, LG, Hijazi, K, Krüger, R, Lee, A, Leistner, R, Pagliano, P, Righi, E, Schneider-Burrus, S, Skov, RL, Tattevin, P, Van Wamel, W, Vos, MC, Voss, A & International Society of Chemotherapy 2018, 'Panton–Valentine leukocidin-positive Staphylococcus aureus: a position statement from the International Society of Chemotherapy', International Journal of Antimicrobial Agents, vol. 51, no. 1, pp. 16-25. https://doi.org/10.1016/j.ijantimicag.2017.11.002
Saeed, Kordo ; Gould, Ian ; Espositio, Silvano ; Ahmad-Saeed, Nusreen ; Ahmed, Salman Shaheer ; Alp, Emine ; Bal, Abhijit M. ; Bassetti, Matteo ; Bonnet, Eric ; Chan, Monica ; Coombs, Geoffrey ; Dancer, Stephanie ; David, Michael Z. ; De Simone, Giuseppe ; Dryden, Matthew ; Guardabassi, Luca ; Hanitsch, Leif G. ; Hijazi, Karolin ; Krüger, Renate ; Lee, Andie ; Leistner, Rasmus ; Pagliano, Pasquale ; Righi, Elda ; Schneider-Burrus, Sylke ; Skov, Robert Leo ; Tattevin, Pierre ; Van Wamel, Willem ; Vos, Margreet C. ; Voss, Andreas ; International Society of Chemotherapy. / Panton–Valentine leukocidin-positive Staphylococcus aureus: a position statement from the International Society of Chemotherapy. In: International Journal of Antimicrobial Agents. 2018 ; Vol. 51, No. 1. pp. 16-25.
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abstract = "Panton–Valentine leukocidin (PVL), a pore-forming cytotoxic secreted toxin, has been associated with severe Staphylococcus aureus pneumonia and prototypical skin lesions. The reported incidence and prevalence of PVL-positive S. aureus (PVLP-SA) varies globally and suffers from a selective reporting bias towards community-associated methicillin-resistant S. aureus (CA-MRSA). Recent studies, however, have identified PVL-positive methicillin-susceptible S. aureus (MSSA) more frequently than previously expected. In this review, a group of experts from four continents affiliated with the International Society of Chemotherapy (ISC) offer a position statement on the important aspects of PVL in S. aureus epidemiology, antimicrobial treatment and decolonisation, and aim to highlight future areas for collaboration and research.",
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AU - Ahmed, Salman Shaheer

AU - Alp, Emine

AU - Bal, Abhijit M.

AU - Bassetti, Matteo

AU - Bonnet, Eric

AU - Chan, Monica

AU - Coombs, Geoffrey

AU - Dancer, Stephanie

AU - David, Michael Z.

AU - De Simone, Giuseppe

AU - Dryden, Matthew

AU - Guardabassi, Luca

AU - Hanitsch, Leif G.

AU - Hijazi, Karolin

AU - Krüger, Renate

AU - Lee, Andie

AU - Leistner, Rasmus

AU - Pagliano, Pasquale

AU - Righi, Elda

AU - Schneider-Burrus, Sylke

AU - Skov, Robert Leo

AU - Tattevin, Pierre

AU - Van Wamel, Willem

AU - Vos, Margreet C.

AU - Voss, Andreas

AU - International Society of Chemotherapy

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