Panton–Valentine leukocidin-positive Staphylococcus aureus: a position statement from the International Society of Chemotherapy

Kordo Saeed, Ian Gould, Silvano Espositio, Nusreen Ahmad-Saeed, Salman Shaheer Ahmed, Emine Alp, Abhijit M. Bal, Matteo Bassetti, Eric Bonnet, Monica Chan, Geoffrey Coombs, Stephanie Dancer, Michael Z. David, Giuseppe De Simone, Matthew Dryden, Luca Guardabassi, Leif G. Hanitsch, Karolin Hijazi, Renate Krüger, Andie LeeRasmus Leistner, Pasquale Pagliano, Elda Righi, Sylke Schneider-Burrus, Robert Leo Skov, Pierre Tattevin, Willem Van Wamel, Margreet C. Vos, Andreas Voss, International Society of Chemotherapy

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Abstract

Panton–Valentine leukocidin (PVL), a pore-forming cytotoxic secreted toxin, has been associated with severe Staphylococcus aureus pneumonia and prototypical skin lesions. The reported incidence and prevalence of PVL-positive S. aureus (PVLP-SA) varies globally and suffers from a selective reporting bias towards community-associated methicillin-resistant S. aureus (CA-MRSA). Recent studies, however, have identified PVL-positive methicillin-susceptible S. aureus (MSSA) more frequently than previously expected. In this review, a group of experts from four continents affiliated with the International Society of Chemotherapy (ISC) offer a position statement on the important aspects of PVL in S. aureus epidemiology, antimicrobial treatment and decolonisation, and aim to highlight future areas for collaboration and research.
Original languageEnglish
Pages (from-to)16-25
Number of pages10
JournalInternational Journal of Antimicrobial Agents
Volume51
Issue number1
Early online date22 Nov 2017
DOIs
Publication statusPublished - Jan 2018

Keywords

  • PVL
  • CA-MRSA
  • MSSA
  • S. aureus
  • infection control

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    Saeed, K., Gould, I., Espositio, S., Ahmad-Saeed, N., Ahmed, S. S., Alp, E., Bal, A. M., Bassetti, M., Bonnet, E., Chan, M., Coombs, G., Dancer, S., David, M. Z., De Simone, G., Dryden, M., Guardabassi, L., Hanitsch, L. G., Hijazi, K., Krüger, R., ... International Society of Chemotherapy (2018). Panton–Valentine leukocidin-positive Staphylococcus aureus: a position statement from the International Society of Chemotherapy. International Journal of Antimicrobial Agents, 51(1), 16-25. https://doi.org/10.1016/j.ijantimicag.2017.11.002