### Abstract

Original language | English |
---|---|

Pages (from-to) | 651-66 |

Number of pages | 16 |

Journal | Physics in Medicine and Biology |

Volume | 43 |

Issue number | 3 |

Publication status | Published - 1998 |

### Fingerprint

### Keywords

- Algorithms
- Astrocytoma
- Biophysical Phenomena
- Biophysics
- Brain Neoplasms
- Carbon Radioisotopes
- Colonic Neoplasms
- Female
- Humans
- Image Processing, Computer-Assisted
- Least-Squares Analysis
- Middle Aged
- Models, Theoretical
- Phantoms, Imaging
- Software
- Thymidine
- Tomography, Emission-Computed

### Cite this

*Physics in Medicine and Biology*,

*43*(3), 651-66.

**Parametric image reconstruction using spectral analysis of PET projection data.** / Meikle, S R; Matthews, J C; Cunningham, V J; Bailey, D L; Livieratos, L; Jones, Terry; Price, Pat.

Research output: Contribution to journal › Article

*Physics in Medicine and Biology*, vol. 43, no. 3, pp. 651-66.

}

TY - JOUR

T1 - Parametric image reconstruction using spectral analysis of PET projection data

AU - Meikle, S R

AU - Matthews, J C

AU - Cunningham, V J

AU - Bailey, D L

AU - Livieratos, L

AU - Jones, Terry

AU - Price, Pat

PY - 1998

Y1 - 1998

N2 - Spectral analysis is a general modelling approach that enables calculation of parametric images from reconstructed tracer kinetic data independent of an assumed compartmental structure. We investigated the validity of applying spectral analysis directly to projection data motivated by the advantages that: (i) the number of reconstructions is reduced by an order of magnitude and (ii) iterative reconstruction becomes practical which may improve signal-to-noise ratio (SNR). A dynamic software phantom with typical 2-[11C]thymidine kinetics was used to compare projection-based and image-based methods and to assess bias-variance trade-offs using iterative expectation maximization (EM) reconstruction. We found that the two approaches are not exactly equivalent due to properties of the non-negative least-squares algorithm. However, the differences are small (<5%) and mainly affect parameters related to early and late time points on the impulse response function (K1 and, to a lesser extent, VD). The optimal number of EM iteration was 15-30 with up to a two-fold improvement in SNR over filtered back projection. We conclude that projection-based spectral analysis with EM reconstruction yields accurate parametric images with high SNR and has potential application to a wide range of positron emission tomography ligands.

AB - Spectral analysis is a general modelling approach that enables calculation of parametric images from reconstructed tracer kinetic data independent of an assumed compartmental structure. We investigated the validity of applying spectral analysis directly to projection data motivated by the advantages that: (i) the number of reconstructions is reduced by an order of magnitude and (ii) iterative reconstruction becomes practical which may improve signal-to-noise ratio (SNR). A dynamic software phantom with typical 2-[11C]thymidine kinetics was used to compare projection-based and image-based methods and to assess bias-variance trade-offs using iterative expectation maximization (EM) reconstruction. We found that the two approaches are not exactly equivalent due to properties of the non-negative least-squares algorithm. However, the differences are small (<5%) and mainly affect parameters related to early and late time points on the impulse response function (K1 and, to a lesser extent, VD). The optimal number of EM iteration was 15-30 with up to a two-fold improvement in SNR over filtered back projection. We conclude that projection-based spectral analysis with EM reconstruction yields accurate parametric images with high SNR and has potential application to a wide range of positron emission tomography ligands.

KW - Algorithms

KW - Astrocytoma

KW - Biophysical Phenomena

KW - Biophysics

KW - Brain Neoplasms

KW - Carbon Radioisotopes

KW - Colonic Neoplasms

KW - Female

KW - Humans

KW - Image Processing, Computer-Assisted

KW - Least-Squares Analysis

KW - Middle Aged

KW - Models, Theoretical

KW - Phantoms, Imaging

KW - Software

KW - Thymidine

KW - Tomography, Emission-Computed

M3 - Article

C2 - 9533143

VL - 43

SP - 651

EP - 666

JO - Physics in Medicine and Biology

JF - Physics in Medicine and Biology

SN - 0031-9155

IS - 3

ER -