Paraoxonase 1 (PON1) and stroke; the dilemma of genetic variation

Amir Tajbakhsh, Mehdi Rezaee, Mahdi Rivandi, Faranak Forouzanfar, Fahimeh Afzaljavan, Alireza Pasdar*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

11 Citations (Scopus)

Abstract

Ischaemic stroke, which is mostly caused by atherosclerosis, is one of the most widely causes of mortality and morbidity. One of the most important enzymatic activities of paraoxonase-1 (PON1) in association with high-density lipoprotein (HDL) is the prevention of low-density lipoprotein (LDL) oxidation, which gives it an anti-atherogenic activity. PON1 expression and activity is influenced by various factors; the most important of which is genetic polymorphism, mainly single nucleotide polymorphisms (SNPs). The results of various studies in different populations indicate that some SNPs of the PON1 gene are associated with stroke. Therefore, in this review we studied various researches, in which the association of PON1 SNPs with stroke had been investigated in different populations.

Original languageEnglish
Pages (from-to)1298-1305
Number of pages8
JournalClinical Biochemistry
Volume50
Issue number18
DOIs
Publication statusPublished - Dec 2017

Keywords

  • Association
  • Atherosclerosis
  • Ischaemic stroke
  • Paraoxonase-1
  • Single nucleotide polymorphism
  • Stroke

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