Parvalbumin-positive CA1 interneurons are required for spatial working but not for reference memory

Andrew J Murray, Jonas-Frederic Sauer, Gernot Riedel, Christina McClure, Laura Ansel, Lesley Cheyne, Marlene Bartos, William Wisden, Peer Wulff

Research output: Contribution to journalArticle

156 Citations (Scopus)

Abstract

Parvalbumin-positive GABAergic interneurons in cortical circuits are hypothesized to control cognitive function. To test this idea directly, we functionally removed parvalbumin-positive interneurons selectively from hippocampal CA1 in mice. We found that parvalbumin-positive interneurons are dispensable for spatial reference, but are essential for spatial working memory.
Original languageEnglish
Pages (from-to)297-299
Number of pages3
JournalNature Neuroscience
Volume14
Issue number3
Early online date30 Jan 2011
DOIs
Publication statusPublished - Mar 2011

Fingerprint

Parvalbumins
Interneurons
Short-Term Memory
Cognition

Cite this

Parvalbumin-positive CA1 interneurons are required for spatial working but not for reference memory. / Murray, Andrew J; Sauer, Jonas-Frederic; Riedel, Gernot; McClure, Christina; Ansel, Laura; Cheyne, Lesley; Bartos, Marlene; Wisden, William; Wulff, Peer.

In: Nature Neuroscience, Vol. 14, No. 3, 03.2011, p. 297-299.

Research output: Contribution to journalArticle

Murray, AJ, Sauer, J-F, Riedel, G, McClure, C, Ansel, L, Cheyne, L, Bartos, M, Wisden, W & Wulff, P 2011, 'Parvalbumin-positive CA1 interneurons are required for spatial working but not for reference memory', Nature Neuroscience, vol. 14, no. 3, pp. 297-299. https://doi.org/10.1038/nn.2751
Murray, Andrew J ; Sauer, Jonas-Frederic ; Riedel, Gernot ; McClure, Christina ; Ansel, Laura ; Cheyne, Lesley ; Bartos, Marlene ; Wisden, William ; Wulff, Peer. / Parvalbumin-positive CA1 interneurons are required for spatial working but not for reference memory. In: Nature Neuroscience. 2011 ; Vol. 14, No. 3. pp. 297-299.
@article{bb3af1b06ff345e58dc977dafe5a3d1a,
title = "Parvalbumin-positive CA1 interneurons are required for spatial working but not for reference memory",
abstract = "Parvalbumin-positive GABAergic interneurons in cortical circuits are hypothesized to control cognitive function. To test this idea directly, we functionally removed parvalbumin-positive interneurons selectively from hippocampal CA1 in mice. We found that parvalbumin-positive interneurons are dispensable for spatial reference, but are essential for spatial working memory.",
author = "Murray, {Andrew J} and Jonas-Frederic Sauer and Gernot Riedel and Christina McClure and Laura Ansel and Lesley Cheyne and Marlene Bartos and William Wisden and Peer Wulff",
year = "2011",
month = "3",
doi = "10.1038/nn.2751",
language = "English",
volume = "14",
pages = "297--299",
journal = "Nature Neuroscience",
issn = "1097-6256",
publisher = "Nature Publishing Group",
number = "3",

}

TY - JOUR

T1 - Parvalbumin-positive CA1 interneurons are required for spatial working but not for reference memory

AU - Murray, Andrew J

AU - Sauer, Jonas-Frederic

AU - Riedel, Gernot

AU - McClure, Christina

AU - Ansel, Laura

AU - Cheyne, Lesley

AU - Bartos, Marlene

AU - Wisden, William

AU - Wulff, Peer

PY - 2011/3

Y1 - 2011/3

N2 - Parvalbumin-positive GABAergic interneurons in cortical circuits are hypothesized to control cognitive function. To test this idea directly, we functionally removed parvalbumin-positive interneurons selectively from hippocampal CA1 in mice. We found that parvalbumin-positive interneurons are dispensable for spatial reference, but are essential for spatial working memory.

AB - Parvalbumin-positive GABAergic interneurons in cortical circuits are hypothesized to control cognitive function. To test this idea directly, we functionally removed parvalbumin-positive interneurons selectively from hippocampal CA1 in mice. We found that parvalbumin-positive interneurons are dispensable for spatial reference, but are essential for spatial working memory.

U2 - 10.1038/nn.2751

DO - 10.1038/nn.2751

M3 - Article

C2 - 21278730

VL - 14

SP - 297

EP - 299

JO - Nature Neuroscience

JF - Nature Neuroscience

SN - 1097-6256

IS - 3

ER -