Parvalbumin-positive CA1 interneurons are required for spatial working but not for reference memory

Andrew J Murray; Jonas-Frederic Sauer; Gernot Riedel; Christina McClure; Laura Ansel; Lesley Cheyne; Marlene Bartos; William Wisden; Peer Wulff

doi:10.1038/nn.2751

Parvalbumin-positive CA1 interneurons are required for spatial working but not for reference memory

Andrew J Murray, Jonas-Frederic Sauer, Gernot Riedel, Christina McClure, Laura Ansel, Lesley Cheyne, Marlene Bartos, William Wisden, Peer Wulff

Research output: Contribution to journal › Article › peer-review

225 Citations (Scopus)

Abstract

Parvalbumin-positive GABAergic interneurons in cortical circuits are hypothesized to control cognitive function. To test this idea directly, we functionally removed parvalbumin-positive interneurons selectively from hippocampal CA1 in mice. We found that parvalbumin-positive interneurons are dispensable for spatial reference, but are essential for spatial working memory.

Original language	English
Pages (from-to)	297-299
Number of pages	3
Journal	Nature Neuroscience
Volume	14
Issue number	3
Early online date	30 Jan 2011
DOIs	https://doi.org/10.1038/nn.2751
Publication status	Published - Mar 2011

Access to Document

10.1038/nn.2751

Cite this

@article{bb3af1b06ff345e58dc977dafe5a3d1a,

title = "Parvalbumin-positive CA1 interneurons are required for spatial working but not for reference memory",

abstract = "Parvalbumin-positive GABAergic interneurons in cortical circuits are hypothesized to control cognitive function. To test this idea directly, we functionally removed parvalbumin-positive interneurons selectively from hippocampal CA1 in mice. We found that parvalbumin-positive interneurons are dispensable for spatial reference, but are essential for spatial working memory.",

author = "Murray, {Andrew J} and Jonas-Frederic Sauer and Gernot Riedel and Christina McClure and Laura Ansel and Lesley Cheyne and Marlene Bartos and William Wisden and Peer Wulff",

year = "2011",

month = mar,

doi = "10.1038/nn.2751",

language = "English",

volume = "14",

pages = "297--299",

journal = "Nature Neuroscience",

issn = "1546-1726",

publisher = "Nature Publishing Group",

number = "3",

}

TY - JOUR

T1 - Parvalbumin-positive CA1 interneurons are required for spatial working but not for reference memory

AU - Murray, Andrew J

AU - Sauer, Jonas-Frederic

AU - Riedel, Gernot

AU - McClure, Christina

AU - Ansel, Laura

AU - Cheyne, Lesley

AU - Bartos, Marlene

AU - Wisden, William

AU - Wulff, Peer

PY - 2011/3

Y1 - 2011/3

N2 - Parvalbumin-positive GABAergic interneurons in cortical circuits are hypothesized to control cognitive function. To test this idea directly, we functionally removed parvalbumin-positive interneurons selectively from hippocampal CA1 in mice. We found that parvalbumin-positive interneurons are dispensable for spatial reference, but are essential for spatial working memory.

AB - Parvalbumin-positive GABAergic interneurons in cortical circuits are hypothesized to control cognitive function. To test this idea directly, we functionally removed parvalbumin-positive interneurons selectively from hippocampal CA1 in mice. We found that parvalbumin-positive interneurons are dispensable for spatial reference, but are essential for spatial working memory.

U2 - 10.1038/nn.2751

DO - 10.1038/nn.2751

M3 - Article

C2 - 21278730

SN - 1546-1726

VL - 14

SP - 297

EP - 299

JO - Nature Neuroscience

JF - Nature Neuroscience

IS - 3

ER -

Parvalbumin-positive CA1 interneurons are required for spatial working but not for reference memory

Abstract

Access to Document

Fingerprint

Cite this