Parvalbumin-positive CA1 interneurons are required for spatial working but not for reference memory

Andrew J Murray, Jonas-Frederic Sauer, Gernot Riedel, Christina McClure, Laura Ansel, Lesley Cheyne, Marlene Bartos, William Wisden, Peer Wulff

Research output: Contribution to journalArticlepeer-review

172 Citations (Scopus)

Abstract

Parvalbumin-positive GABAergic interneurons in cortical circuits are hypothesized to control cognitive function. To test this idea directly, we functionally removed parvalbumin-positive interneurons selectively from hippocampal CA1 in mice. We found that parvalbumin-positive interneurons are dispensable for spatial reference, but are essential for spatial working memory.
Original languageEnglish
Pages (from-to)297-299
Number of pages3
JournalNature Neuroscience
Volume14
Issue number3
Early online date30 Jan 2011
DOIs
Publication statusPublished - Mar 2011

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