PATENT: Antibody molecules and uses thereof.

Neil A. R. Gow; Fiona M. Rudkin; Lars-Peter Erwig; Allan Jensen

PATENT: Antibody molecules and uses thereof.

Neil A. R. Gow (Inventor), Fiona M. Rudkin (Inventor), Lars-Peter Erwig (Inventor), Allan Jensen (Inventor)

Research output: Patent

Abstract

This invention relates to recombinant human antibody molecules. The antibodies bind fungal antigens, for example from Candida spp. Human antibody encoding genes targeting clinically relevant Candida epitopes have been isolated from single B cells from carefully selected donors and screened with specified types of protein or cell wall extract. The panel of purified, fully human recombinant IgGl mAbs generated displayed a diverse range of specific binding profiles and demonstrated efficacy in a disease model. The fully human mAbs and derivatives thereof have utility in the generation of diagnostics, therapeutics and vaccines.

Original language	English
Patent number	WO 2016/142660 Al
IPC	C07K 16/14 ,G01N 33/53
Priority date	6/03/15
Filing date	4/03/16
Publication status	Published - 15 Sep 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "PATENT: Antibody molecules and uses thereof.",

abstract = "This invention relates to recombinant human antibody molecules. The antibodies bind fungal antigens, for example from Candida spp. Human antibody encoding genes targeting clinically relevant Candida epitopes have been isolated from single B cells from carefully selected donors and screened with specified types of protein or cell wall extract. The panel of purified, fully human recombinant IgGl mAbs generated displayed a diverse range of specific binding profiles and demonstrated efficacy in a disease model. The fully human mAbs and derivatives thereof have utility in the generation of diagnostics, therapeutics and vaccines.",

author = "Gow, {Neil A. R.} and Rudkin, {Fiona M.} and Lars-Peter Erwig and Allan Jensen",

year = "2016",

month = sep,

day = "15",

language = "English",

publisher = "World Intellectual Property Organization",

type = "Patent",

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AU - Gow, Neil A. R.

AU - Rudkin, Fiona M.

AU - Erwig, Lars-Peter

AU - Jensen, Allan

PY - 2016/9/15

Y1 - 2016/9/15

N2 - This invention relates to recombinant human antibody molecules. The antibodies bind fungal antigens, for example from Candida spp. Human antibody encoding genes targeting clinically relevant Candida epitopes have been isolated from single B cells from carefully selected donors and screened with specified types of protein or cell wall extract. The panel of purified, fully human recombinant IgGl mAbs generated displayed a diverse range of specific binding profiles and demonstrated efficacy in a disease model. The fully human mAbs and derivatives thereof have utility in the generation of diagnostics, therapeutics and vaccines.

AB - This invention relates to recombinant human antibody molecules. The antibodies bind fungal antigens, for example from Candida spp. Human antibody encoding genes targeting clinically relevant Candida epitopes have been isolated from single B cells from carefully selected donors and screened with specified types of protein or cell wall extract. The panel of purified, fully human recombinant IgGl mAbs generated displayed a diverse range of specific binding profiles and demonstrated efficacy in a disease model. The fully human mAbs and derivatives thereof have utility in the generation of diagnostics, therapeutics and vaccines.

M3 - Patent

M1 - WO 2016/142660 Al

Y2 - 2016/03/04

PB - World Intellectual Property Organization

ER -

PATENT: Antibody molecules and uses thereof.

Abstract

UN SDGs

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