Pathogenic role of glial cells in Parkinson's disease

Peter Teismann, Kim Tieu, Oren Cohen, Dong-Kug Choi, Du Chu Wu, Daniel Marks, Miquel Vila, Vernice Jackson-Lewis, Serge Przedborski

Research output: Contribution to journalArticle

208 Citations (Scopus)

Abstract

Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive loss of the dopaminergic neurons in the substantia nigra pars compacta (SNpc). The loss of these neurons is associated with a glial response composed mainly of activated microglial cells and, to a lesser extent, of reactive astrocytes. This glial response may be the source of trophic factors and can protect against reactive oxygen species and glutamate. Alternatively, this glial response can also mediate a variety of deleterious events related to the production of pro-oxidant reactive species, and pro-inflammatory prostaglandin and cytokines. We discuss the potential protective and deleterious effects of glial cells in the SNpc of PD and examine how those factors may contribute to the pathogenesis of this disease.
Original languageEnglish
Pages (from-to)121-129
Number of pages9
JournalMovement Disorders
Volume18
Issue number2
Early online date28 Oct 2002
DOIs
Publication statusPublished - 1 Feb 2003

Keywords

  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
  • Adrenergic Agents
  • Animals
  • Astrocytes
  • Dopamine Agents
  • Glial Cell Line-Derived Neurotrophic Factor
  • Mice
  • Microglia
  • Nerve Growth Factors
  • Neuroprotective Agents
  • Oxidopamine
  • Parkinsonian Disorders
  • Reactive Oxygen Species
  • Substantia Nigra
  • astrocyte
  • gliosis
  • IL-1ß
  • iNOS
  • microglia
  • MPTP
  • neurodegeneration
  • Parkinson's disease

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    Teismann, P., Tieu, K., Cohen, O., Choi, D-K., Wu, D. C., Marks, D., Vila, M., Jackson-Lewis, V., & Przedborski, S. (2003). Pathogenic role of glial cells in Parkinson's disease. Movement Disorders, 18(2), 121-129. https://doi.org/10.1002/mds.10332