Pathophysiological importance of antineutrophil antibodies in vasculitis

Neil Basu, Lars-Peter Erwig

Research output: Contribution to journalLiterature review

1 Citation (Scopus)

Abstract

Purpose of review: We endeavour to provide a brief overview of the recent advances in understanding of how antineutrophil cytoplasmic antibodies (ANCAs) contribute to the pathophysiology of vasculitis.

Recent findings: Substantial progress has been made in our understanding of the immunopathogenesis of ANCA-associated vasculitides. Compelling evidence from in-vitro studies and experimental models in conjunction with clinical trials has confirmed that ANCAs directly contribute to the evolution and progression of the disease process. A new ANCA, directed against human lysosome membrane protein-2 (LAMP-2), has recently been described as a sensitive and specific marker for renal vasculitis and we discuss its potential impact for diagnosis and therapy. Furthermore, high-throughput approaches are starting to identify genetic patterns that may identify patients likely to respond to specific therapy or having a high probability of relapse.

Summary: It has become increasingly clear over the last two decades that ANCA IgG is pathogenic in vasculitis. Novel therapies aimed at selected cell populations or blocking specific pathogenic pathways offer hope for more selectively treating this heterogeneous group of patients, while avoiding nonspecific immunosuppression and its adverse effects.
Original languageEnglish
Pages (from-to)25-29
Number of pages5
JournalCurrent Opinion in Hematology
Volume18
Issue number1
DOIs
Publication statusPublished - Jan 2011

Fingerprint

Antineutrophil Cytoplasmic Antibodies
Vasculitis
Antibodies
Lysosomes
Immunosuppression
Disease Progression
Membrane Proteins
Theoretical Models
Therapeutics
Immunoglobulin G
Clinical Trials
Kidney
Recurrence
Population

Keywords

  • antineutrophil cytoplasmic antibodies
  • autoimmune disease
  • vasculitis

Cite this

Pathophysiological importance of antineutrophil antibodies in vasculitis. / Basu, Neil; Erwig, Lars-Peter.

In: Current Opinion in Hematology, Vol. 18, No. 1, 01.2011, p. 25-29.

Research output: Contribution to journalLiterature review

Basu, Neil ; Erwig, Lars-Peter. / Pathophysiological importance of antineutrophil antibodies in vasculitis. In: Current Opinion in Hematology. 2011 ; Vol. 18, No. 1. pp. 25-29.
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