Pathophysiology of diabetic erectile dysfunction: potential contribution of vasa nervorum and advanced glycation endproducts

S Cellek, N E Cameron, M A Cotter, A Muneer

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Erectile dysfunction (ED) due to diabetes mellitus remains difficult to treat medically despite advances in pharmacotherapeutic approaches in the field. This unmet need has resulted in a recent re-focus on the pathophysiology, in order to understand the cellular and molecular mechanisms leading to ED in diabetes. Diabetes-induced ED is often resistant to PDE5 inhibitor treatment, thus there is a need to discover targets that may lead to novel approaches for a successful treatment. The aim of this brief review is to update the reader in some of the latest development on that front, with a particular focus on the role of impaired neuronal blood flow and the formation of advanced glycation endproducts.International Journal of Impotence Research adv
Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalInternational Journal of Impotence Research
Volume25
Issue number1
Early online date23 Aug 2012
DOIs
Publication statusPublished - Jan 2013

Keywords

  • advanced glycation end products
  • diabetes mellitus
  • erectile dysfunction
  • hypoxia
  • microvessel
  • nitric oxide
  • vasa nervorum

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