Pattern recognition

recent insights from Dectin-1

Delyth M Reid, Neil A R Gow, Gordon D Brown

Research output: Contribution to journalArticle

191 Citations (Scopus)

Abstract

The beta-glucan receptor Dectin-1 is an archetypical non-toll-like pattern recognition receptor expressed predominantly by myeloid cells, which can induce its own intracellular signalling and can mediate a variety of cellular responses, such as cytokine production. Recent identification of the components of these signalling pathways, such as Syk kinase, CARD9 and Raf-1, has provided novel insights into the molecular mechanisms underlying Dectin-1 function. Furthermore, a broader appreciation of the cellular responses mediated by this receptor and the effects of interactions with other receptors, including the TLRs, have greatly furthered our understanding of innate immunity and how this drives the development of adaptive immunity, particularly Th17 responses. Recent studies have highlighted the importance of Dectin-1 in anti-fungal immunity, in both mice and humans, and have suggested a possible involvement of this receptor in the control of mycobacterial infections.
Original languageEnglish
Pages (from-to)30-37
Number of pages8
JournalCurrent Opinion in Immunology
Volume21
Issue number1
DOIs
Publication statusPublished - Feb 2009

Fingerprint

Proto-Oncogene Proteins c-raf
Pattern Recognition Receptors
Adaptive Immunity
Myeloid Cells
Infection Control
Innate Immunity
Immunity
Cytokines
dectin 1
beta-glucan receptor
Syk Kinase

Keywords

  • animals
  • CARD signaling adaptor proteins
  • humans
  • immunity, cellular
  • immunity, innate
  • interleukin-17
  • intracellular signaling peptides and proteins
  • membrane proteins
  • mice
  • mycobacterium infections
  • mycoses
  • myeloid cells
  • nerve tissue proteins
  • protein-tyrosine kinases
  • proto-oncogene proteins c-raf
  • signal transduction
  • Th1 cells
  • toll-like receptors

Cite this

Pattern recognition : recent insights from Dectin-1. / Reid, Delyth M; Gow, Neil A R; Brown, Gordon D.

In: Current Opinion in Immunology, Vol. 21, No. 1, 02.2009, p. 30-37.

Research output: Contribution to journalArticle

Reid, Delyth M ; Gow, Neil A R ; Brown, Gordon D. / Pattern recognition : recent insights from Dectin-1. In: Current Opinion in Immunology. 2009 ; Vol. 21, No. 1. pp. 30-37.
@article{1a9ea151195846cb830d53fcdeb842f5,
title = "Pattern recognition: recent insights from Dectin-1",
abstract = "The beta-glucan receptor Dectin-1 is an archetypical non-toll-like pattern recognition receptor expressed predominantly by myeloid cells, which can induce its own intracellular signalling and can mediate a variety of cellular responses, such as cytokine production. Recent identification of the components of these signalling pathways, such as Syk kinase, CARD9 and Raf-1, has provided novel insights into the molecular mechanisms underlying Dectin-1 function. Furthermore, a broader appreciation of the cellular responses mediated by this receptor and the effects of interactions with other receptors, including the TLRs, have greatly furthered our understanding of innate immunity and how this drives the development of adaptive immunity, particularly Th17 responses. Recent studies have highlighted the importance of Dectin-1 in anti-fungal immunity, in both mice and humans, and have suggested a possible involvement of this receptor in the control of mycobacterial infections.",
keywords = "animals, CARD signaling adaptor proteins, humans, immunity, cellular, immunity, innate, interleukin-17, intracellular signaling peptides and proteins, membrane proteins, mice, mycobacterium infections, mycoses, myeloid cells, nerve tissue proteins, protein-tyrosine kinases, proto-oncogene proteins c-raf, signal transduction, Th1 cells, toll-like receptors",
author = "Reid, {Delyth M} and Gow, {Neil A R} and Brown, {Gordon D}",
year = "2009",
month = "2",
doi = "10.1016/j.coi.2009.01.003",
language = "English",
volume = "21",
pages = "30--37",
journal = "Current Opinion in Immunology",
issn = "0952-7915",
publisher = "Elsevier Limited",
number = "1",

}

TY - JOUR

T1 - Pattern recognition

T2 - recent insights from Dectin-1

AU - Reid, Delyth M

AU - Gow, Neil A R

AU - Brown, Gordon D

PY - 2009/2

Y1 - 2009/2

N2 - The beta-glucan receptor Dectin-1 is an archetypical non-toll-like pattern recognition receptor expressed predominantly by myeloid cells, which can induce its own intracellular signalling and can mediate a variety of cellular responses, such as cytokine production. Recent identification of the components of these signalling pathways, such as Syk kinase, CARD9 and Raf-1, has provided novel insights into the molecular mechanisms underlying Dectin-1 function. Furthermore, a broader appreciation of the cellular responses mediated by this receptor and the effects of interactions with other receptors, including the TLRs, have greatly furthered our understanding of innate immunity and how this drives the development of adaptive immunity, particularly Th17 responses. Recent studies have highlighted the importance of Dectin-1 in anti-fungal immunity, in both mice and humans, and have suggested a possible involvement of this receptor in the control of mycobacterial infections.

AB - The beta-glucan receptor Dectin-1 is an archetypical non-toll-like pattern recognition receptor expressed predominantly by myeloid cells, which can induce its own intracellular signalling and can mediate a variety of cellular responses, such as cytokine production. Recent identification of the components of these signalling pathways, such as Syk kinase, CARD9 and Raf-1, has provided novel insights into the molecular mechanisms underlying Dectin-1 function. Furthermore, a broader appreciation of the cellular responses mediated by this receptor and the effects of interactions with other receptors, including the TLRs, have greatly furthered our understanding of innate immunity and how this drives the development of adaptive immunity, particularly Th17 responses. Recent studies have highlighted the importance of Dectin-1 in anti-fungal immunity, in both mice and humans, and have suggested a possible involvement of this receptor in the control of mycobacterial infections.

KW - animals

KW - CARD signaling adaptor proteins

KW - humans

KW - immunity, cellular

KW - immunity, innate

KW - interleukin-17

KW - intracellular signaling peptides and proteins

KW - membrane proteins

KW - mice

KW - mycobacterium infections

KW - mycoses

KW - myeloid cells

KW - nerve tissue proteins

KW - protein-tyrosine kinases

KW - proto-oncogene proteins c-raf

KW - signal transduction

KW - Th1 cells

KW - toll-like receptors

U2 - 10.1016/j.coi.2009.01.003

DO - 10.1016/j.coi.2009.01.003

M3 - Article

VL - 21

SP - 30

EP - 37

JO - Current Opinion in Immunology

JF - Current Opinion in Immunology

SN - 0952-7915

IS - 1

ER -