Pattern recognition receptors in antifungal immunity

Anthony Plato, Sarah E Hardison, Gordon D Brown (Corresponding Author)

Research output: Contribution to journalArticle

95 Citations (Scopus)
6 Downloads (Pure)

Abstract

Receptors of the innate immune system are the first line of defence against infection, being able to recognise and initiate an inflammatory response to invading microorganisms. The Toll-like (TLR), NOD-like (NLR), RIG-I-like (RLR) and C-type lectin-like receptors (CLR) are four receptor families that contribute to the recognition of a vast range of species, including fungi. Many of these pattern recognition receptors (PRRs) are able to initiate innate immunity and polarise adaptive responses upon the recognition of fungal cell wall components and other conserved molecular patterns, including fungal nucleic acids. These receptors induce effective mechanisms of fungal clearance in normal hosts, but medical interventions, immunosuppression or genetic predisposition can lead to susceptibility to fungal infections. In this review, we highlight the importance of PRRs in fungal infection, specifically CLRs, which are the major PRR involved. We will describe specific PRRs in detail, the importance of receptor collaboration in fungal recognition and clearance, and describe how genetic aberrations in PRRs can contribute to disease pathology.

Original languageEnglish
Pages (from-to)97-106
Number of pages10
JournalSeminars in Immunopathology
Volume37
Issue number2
Early online date25 Nov 2014
DOIs
Publication statusPublished - Mar 2015

Keywords

  • C-type lectin
  • dectin-1
  • syk
  • antifungal
  • Th17

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