Patterns of variability at the major histocompatibility class II alpha locus in Atlantic salmon contrast with those at the class I locus.

S. Consuegra, H. -. J. Megens, K. Leon, Rene Josephus Maria Stet, W. C. Jordan

    Research output: Contribution to journalArticle

    36 Citations (Scopus)

    Abstract

    In order to investigate the mechanisms creating and maintaining variability at the major histocompatibility (MH) class II alpha ( DAA) locus we examined patterns of polymorphism in two isolated Atlantic salmon populations which share a common post-glacial origin. As expected from their common origin, but contrary to the observation at the MH class I locus, these populations shared the majority of DAA alleles: out of 17 sequences observed, 11 were common to both populations. Recombination seems to play a more important role in the origin of new alleles at the class II alpha locus than at the class I locus. A greater than expected proportion of sites inferred to be positively selected ( potentially peptide binding residues, PBRs) were found to be involved in recombination events, suggesting a mechanism for increasing MH variability through an interaction between recombination and natural selection. Thus it appears that although selection and recombination are important mechanisms for the evolution of both class II alpha and class I loci in the Atlantic salmon, the pattern of variability differs markedly between these classes of MH loci.

    Original languageEnglish
    Pages (from-to)16-24
    Number of pages8
    JournalImmunogenetics
    Volume57
    DOIs
    Publication statusPublished - 2005

    Keywords

    • MHC
    • class II alpha
    • recombination
    • natural selection
    • Atlantic salmon
    • MHC-CLASS-I
    • AMINO-ACID SITES
    • HLA-B ALLELES
    • NUCLEOTIDE SUBSTITUTION
    • OVERDOMINANT SELECTION
    • PHYLOGENETIC ANALYSIS
    • ANTIGEN PRESENTATION
    • LIKELIHOOD METHOD
    • EVOLUTION
    • COMPLEX

    Cite this

    Patterns of variability at the major histocompatibility class II alpha locus in Atlantic salmon contrast with those at the class I locus. / Consuegra, S.; Megens, H. -. J.; Leon, K.; Stet, Rene Josephus Maria; Jordan, W. C.

    In: Immunogenetics, Vol. 57, 2005, p. 16-24.

    Research output: Contribution to journalArticle

    Consuegra, S. ; Megens, H. -. J. ; Leon, K. ; Stet, Rene Josephus Maria ; Jordan, W. C. / Patterns of variability at the major histocompatibility class II alpha locus in Atlantic salmon contrast with those at the class I locus. In: Immunogenetics. 2005 ; Vol. 57. pp. 16-24.
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    abstract = "In order to investigate the mechanisms creating and maintaining variability at the major histocompatibility (MH) class II alpha ( DAA) locus we examined patterns of polymorphism in two isolated Atlantic salmon populations which share a common post-glacial origin. As expected from their common origin, but contrary to the observation at the MH class I locus, these populations shared the majority of DAA alleles: out of 17 sequences observed, 11 were common to both populations. Recombination seems to play a more important role in the origin of new alleles at the class II alpha locus than at the class I locus. A greater than expected proportion of sites inferred to be positively selected ( potentially peptide binding residues, PBRs) were found to be involved in recombination events, suggesting a mechanism for increasing MH variability through an interaction between recombination and natural selection. Thus it appears that although selection and recombination are important mechanisms for the evolution of both class II alpha and class I loci in the Atlantic salmon, the pattern of variability differs markedly between these classes of MH loci.",
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    AU - Consuegra, S.

    AU - Megens, H. -. J.

    AU - Leon, K.

    AU - Stet, Rene Josephus Maria

    AU - Jordan, W. C.

    PY - 2005

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    N2 - In order to investigate the mechanisms creating and maintaining variability at the major histocompatibility (MH) class II alpha ( DAA) locus we examined patterns of polymorphism in two isolated Atlantic salmon populations which share a common post-glacial origin. As expected from their common origin, but contrary to the observation at the MH class I locus, these populations shared the majority of DAA alleles: out of 17 sequences observed, 11 were common to both populations. Recombination seems to play a more important role in the origin of new alleles at the class II alpha locus than at the class I locus. A greater than expected proportion of sites inferred to be positively selected ( potentially peptide binding residues, PBRs) were found to be involved in recombination events, suggesting a mechanism for increasing MH variability through an interaction between recombination and natural selection. Thus it appears that although selection and recombination are important mechanisms for the evolution of both class II alpha and class I loci in the Atlantic salmon, the pattern of variability differs markedly between these classes of MH loci.

    AB - In order to investigate the mechanisms creating and maintaining variability at the major histocompatibility (MH) class II alpha ( DAA) locus we examined patterns of polymorphism in two isolated Atlantic salmon populations which share a common post-glacial origin. As expected from their common origin, but contrary to the observation at the MH class I locus, these populations shared the majority of DAA alleles: out of 17 sequences observed, 11 were common to both populations. Recombination seems to play a more important role in the origin of new alleles at the class II alpha locus than at the class I locus. A greater than expected proportion of sites inferred to be positively selected ( potentially peptide binding residues, PBRs) were found to be involved in recombination events, suggesting a mechanism for increasing MH variability through an interaction between recombination and natural selection. Thus it appears that although selection and recombination are important mechanisms for the evolution of both class II alpha and class I loci in the Atlantic salmon, the pattern of variability differs markedly between these classes of MH loci.

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    KW - Atlantic salmon

    KW - MHC-CLASS-I

    KW - AMINO-ACID SITES

    KW - HLA-B ALLELES

    KW - NUCLEOTIDE SUBSTITUTION

    KW - OVERDOMINANT SELECTION

    KW - PHYLOGENETIC ANALYSIS

    KW - ANTIGEN PRESENTATION

    KW - LIKELIHOOD METHOD

    KW - EVOLUTION

    KW - COMPLEX

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