Pax6 regulates regional development and neuronal migration in the cerebral cortex

A. Talamillo, J. C. Quinn, Jon Martin Collinson, D. Caric, D. J. Price, J. D. West, R. E. Hill

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Mutations in the Pax6 gene disrupt telencephalic development, resulting in a thin cortical plate, expansion of proliferative layers, and the absence of the olfactory bulb. The primary defect in the neuronal cell population of the developing cerebral cortex was analysed by using mouse chimeras containing a mixture of wild-type and Pax6-deficient cells. The chimeric analysis shows that Pax6 influences cellular activity throughout corticogenesis. At early stages, Pax6-deficient and wildtype cells segregate. into exclusive patches, indicating an inability of different cell genotypes to interact. At later stages, cells are sorted further based on telencephalic domains. Pax6-deficient cells are specifically reduced in the mediocaudal domain of the dorsal telencephalon, indicating a role in regionalization. In addition, Pax6 regulates the process of radial migration of neuronal precursors. Loss of Pax6 particularly affects movement of neuronal precursors at the subventricular zone/intermediate zone boundary at a transitional migratory phase essential for entry into the intermediate zone. We suggest that the primary role of Pax6 is the continual regulation of cell surface properties responsible for both cellular identity and radial migration, defects of which cause regional cell sorting and abnormalities of migration in chimeras. (C) 2003 Elsevier Science (USA). All rights reserved.

Original languageEnglish
Pages (from-to)151-163
Number of pages12
JournalDevelopmental Biology
Volume255
Issue number1
DOIs
Publication statusPublished - Mar 2003

Keywords

  • Pax6
  • small eye
  • cerebral cortex
  • neuronal migration
  • cell autonomous
  • cell-migration
  • mammalian telencephalon
  • gene-expression
  • cortical areas
  • radial glia
  • mutant mice
  • eye
  • mouse
  • neocortex
  • forebrain

Cite this

Talamillo, A., Quinn, J. C., Collinson, J. M., Caric, D., Price, D. J., West, J. D., & Hill, R. E. (2003). Pax6 regulates regional development and neuronal migration in the cerebral cortex. Developmental Biology, 255(1), 151-163. https://doi.org/10.1016/S0012-1606(02)00046-5

Pax6 regulates regional development and neuronal migration in the cerebral cortex. / Talamillo, A.; Quinn, J. C.; Collinson, Jon Martin; Caric, D.; Price, D. J.; West, J. D.; Hill, R. E.

In: Developmental Biology, Vol. 255, No. 1, 03.2003, p. 151-163.

Research output: Contribution to journalArticle

Talamillo, A, Quinn, JC, Collinson, JM, Caric, D, Price, DJ, West, JD & Hill, RE 2003, 'Pax6 regulates regional development and neuronal migration in the cerebral cortex', Developmental Biology, vol. 255, no. 1, pp. 151-163. https://doi.org/10.1016/S0012-1606(02)00046-5
Talamillo, A. ; Quinn, J. C. ; Collinson, Jon Martin ; Caric, D. ; Price, D. J. ; West, J. D. ; Hill, R. E. / Pax6 regulates regional development and neuronal migration in the cerebral cortex. In: Developmental Biology. 2003 ; Vol. 255, No. 1. pp. 151-163.
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