Performance of CURB-65 and CURB-age in community-acquired pneumonia

P K Myint, P Sankaran, P Musonda, D N Subramanian, H Ruffell, A C Smith, P Prentice, S M Tariq, A V Kamath

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Abstract

BACKGROUND: Community-acquired pneumonia (CAP) is common and associated with significant mortality. In this study, we validated a newly proposed severity assessment rule for CAP, CURB-age, and also compared with to the currently recommended criteria in UK, CURB-65.

METHODS: We conducted a prospective study in three hospitals in Norfolk and Suffolk, UK. One hundred and ninety patients were included and followed up for 6 weeks.

RESULTS: Of 190 patients, 100 were men (53%). The age range was 18-101 years (median 76 years). Sixty-five (34%) had severe pneumonia by CURB-65 and 54 (28%) had severe pneumonia by CURB-age. There were 54 deaths during follow-up. There were 32 deaths (50%) in severe and 22 deaths (18%) in non-severe group by CURB-65. There were 27 deaths each in both the groups by CURB-age (50% of severe cases and 20% of non-severe cases). For CURB-65, sensitivity, specificity, and positive and negative predictive values were 59.3% (45.0-72.4), 75.7% (67.6-82.7), 49.2% (36.6-61.9) and 82.4% (74.6-88.6), respectively. For CURB-age, the respective values were 50.0% (31.1-63.9), 80.1% (72.4-86.5), 50.0% (36.1-63.9) and 80.1% (72.4-86.5). Exclusion of patients aged < 65 years did not alter the results.

CONCLUSIONS: Despite better specificity in correctly identifying 6-week mortality for CAP, CURB-age appears to be less sensitive than CURB-65. Our findings further assure the usefulness of CURB-65 for predicting mortality in CAP.

Original languageEnglish
Pages (from-to)1345-1350
Number of pages6
JournalInternational Journal of Clinical Practice
Volume63
Issue number9
Early online date10 Aug 2009
DOIs
Publication statusPublished - Sep 2009

Keywords

  • Age Distribution
  • Aged
  • Aged, 80 and over
  • Community-Acquired Infections
  • England
  • Female
  • Humans
  • Male
  • Pneumonia
  • Prospective Studies
  • Sensitivity and Specificity
  • Severity of Illness Index

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    Myint, P. K., Sankaran, P., Musonda, P., Subramanian, D. N., Ruffell, H., Smith, A. C., Prentice, P., Tariq, S. M., & Kamath, A. V. (2009). Performance of CURB-65 and CURB-age in community-acquired pneumonia. International Journal of Clinical Practice, 63(9), 1345-1350. https://doi.org/10.1111/j.1742-1241.2009.02147.x