Perinatal complications and maximising lamb survival in an adolescent paradigm characterised by premature delivery and low birthweight

Jacqueline M. Wallace; Paul O. Shepherd; John S. Milne; Raymond P. Aitken

doi:10.1371/journal.pone.0259890

Perinatal complications and maximising lamb survival in an adolescent paradigm characterised by premature delivery and low birthweight

Jacqueline M. Wallace^* (Corresponding Author), Paul O. Shepherd, John S. Milne, Raymond P. Aitken

^*Corresponding author for this work

The Rowett Institute of Nutrition and Health

Rowett Institute, University of Aberdeen

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

11 Downloads (Pure)

Abstract

The competition for nutrients in overnourished and still-growing adolescent sheep negatively impacts gestation length, colostrum supply and lamb birthweight, all of which may affect neonatal morbidity and survival to weaning. Herein perinatal complications and the requirement for supplementary feeding were analysed in relation to gestational-intake, and the degree of premature delivery and prenatal growth-restriction exhibited. Pregnancies were established by embryo transfer and the mean/standard deviation (SD) gestation length and birthweight of the optimally-fed control group (n = 100) was used to define early delivery and reduced birthweight categories (1.5 and 3.0 SDs below the control mean for each aspect). Control lambs were largely delivered at term (94%), and had a normal birthweight (92%), while very preterm (≤139days, 18.5%) and preterm delivery (140-142days, 54.8%), extremely low birthweight (ELBW; females ≤2838g and males ≤3216g, 21.1%) and low birthweight (LBW; females 2839 to ≤4001g and males 3217 to ≤4372g, 32.2%), were common in the overnourished group (n = 270, P

Original language	English
Article number	e0259890
Number of pages	24
Journal	PloS ONE
Volume	16
Issue number	11
Early online date	15 Nov 2021
DOIs	https://doi.org/10.1371/journal.pone.0259890
Publication status	Published - 15 Nov 2021

Bibliographical note

Acknowledgments
Dr Anja Petrie provided supporting veterinary input in her role as Named Veterinary
Surgeon.
Funding acquisition: Jacqueline M. Wallace.

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Cite this

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title = "Perinatal complications and maximising lamb survival in an adolescent paradigm characterised by premature delivery and low birthweight",

abstract = "The competition for nutrients in overnourished and still-growing adolescent sheep negatively impacts gestation length, colostrum supply and lamb birthweight, all of which may affect neonatal morbidity and survival to weaning. Herein perinatal complications and the requirement for supplementary feeding were analysed in relation to gestational-intake, and the degree of premature delivery and prenatal growth-restriction exhibited. Pregnancies were established by embryo transfer and the mean/standard deviation (SD) gestation length and birthweight of the optimally-fed control group (n = 100) was used to define early delivery and reduced birthweight categories (1.5 and 3.0 SDs below the control mean for each aspect). Control lambs were largely delivered at term (94%), and had a normal birthweight (92%), while very preterm (≤139days, 18.5%) and preterm delivery (140-142days, 54.8%), extremely low birthweight (ELBW; females ≤2838g and males ≤3216g, 21.1%) and low birthweight (LBW; females 2839 to ≤4001g and males 3217 to ≤4372g, 32.2%), were common in the overnourished group (n = 270, P",

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AU - Milne, John S.

AU - Aitken, Raymond P.

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Perinatal complications and maximising lamb survival in an adolescent paradigm characterised by premature delivery and low birthweight

Abstract

Bibliographical note

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