Perinatal selective serotonin reuptake inhibitor exposure and behavioral outcomes: A systematic review and meta-analyses of animal studies

A. S. Ramsteijn; L. Van de Wijer; J. Rando; J. van Luijk; J. R. Homberg; J. D.A. Olivier

doi:10.1016/j.neubiorev.2020.04.010

Perinatal selective serotonin reuptake inhibitor exposure and behavioral outcomes: A systematic review and meta-analyses of animal studies

A. S. Ramsteijn, L. Van de Wijer, J. Rando, J. van Luijk, J. R. Homberg^*, J. D.A. Olivier

^*Corresponding author for this work

The Rowett Institute of Nutrition and Health

Research output: Contribution to journal › Review article › peer-review

26 Citations (Scopus)

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Abstract

In the Western world, 2–5 % of pregnant women use selective serotonin reuptake inhibitor (SSRI) antidepressants. There is no consensus on the potential long-term neurodevelopmental outcomes of early SSRI exposure. Our aim was to determine whether there is an overall effect of perinatal SSRI exposure in animals on a spectrum of behavioral domains. After a comprehensive database search in PubMed, PsycINFO, and Web of Science, we included 99 publications. We performed nine meta-analyses and two qualitative syntheses corresponding to different behavioral categories, aggregating data from thousands of animals. We found evidence for reduced activity and exploration behavior (standardized mean difference (SMD) −0.28 [−0.38, −0.18]), more passive stress coping (SMD −0.37 [−0.52, −0.23]), and less efficient sensory processing (SMD −0.37 [−0.69, −0.06]) in SSRI- versus vehicle-exposed animals. No differences were found for anxiety (p = 0.06), social behavior, learning and memory, ingestive- and reward behavior, motoric behavior, or reflex and pain sensitivity. Exposure in the period equivalent to the human third trimester was associated with the strongest effects.

Original language	English
Pages (from-to)	53-69
Number of pages	17
Journal	Neuroscience and Biobehavioral Reviews
Volume	114
Early online date	19 Apr 2020
DOIs	https://doi.org/10.1016/j.neubiorev.2020.04.010
Publication status	Published - Jul 2020

Bibliographical note

Funding Information:
This work was supported by a ZonMw grant (MKMD project; ID 114024127 ) awarded to JO & AR, and a grant awarded to JH from the Donders Institute for Brain, Cognition and Behavior . Funding bodies had no role in study design, data collection, data analysis, data interpretation, or the writing of the report.

Keywords

Activity and exploration
Animal studies
Antidepressants
Anxiety
Behavior
Developmental exposure
Ingestive and reward behavior
Learning and memory
Meta-analysis
Motoric behavior
Offspring
Pregnancy
Reflex and pain sensitivity
Selective serotonin reuptake inhibitors (SSRIs)
Sensory processing
Sleep and circadian activity
Social behavior
Stress coping
Systematic review
Teratogenic effects

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Ramsteijn_etal_NBR_Perinatal_Selective_Serotonin_VOR
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Cite this

@article{2f682e888b44493dbb476581db38086c,

title = "Perinatal selective serotonin reuptake inhibitor exposure and behavioral outcomes: A systematic review and meta-analyses of animal studies",

abstract = "In the Western world, 2–5 % of pregnant women use selective serotonin reuptake inhibitor (SSRI) antidepressants. There is no consensus on the potential long-term neurodevelopmental outcomes of early SSRI exposure. Our aim was to determine whether there is an overall effect of perinatal SSRI exposure in animals on a spectrum of behavioral domains. After a comprehensive database search in PubMed, PsycINFO, and Web of Science, we included 99 publications. We performed nine meta-analyses and two qualitative syntheses corresponding to different behavioral categories, aggregating data from thousands of animals. We found evidence for reduced activity and exploration behavior (standardized mean difference (SMD) −0.28 [−0.38, −0.18]), more passive stress coping (SMD −0.37 [−0.52, −0.23]), and less efficient sensory processing (SMD −0.37 [−0.69, −0.06]) in SSRI- versus vehicle-exposed animals. No differences were found for anxiety (p = 0.06), social behavior, learning and memory, ingestive- and reward behavior, motoric behavior, or reflex and pain sensitivity. Exposure in the period equivalent to the human third trimester was associated with the strongest effects.",

keywords = "Activity and exploration, Animal studies, Antidepressants, Anxiety, Behavior, Developmental exposure, Ingestive and reward behavior, Learning and memory, Meta-analysis, Motoric behavior, Offspring, Pregnancy, Reflex and pain sensitivity, Selective serotonin reuptake inhibitors (SSRIs), Sensory processing, Sleep and circadian activity, Social behavior, Stress coping, Systematic review, Teratogenic effects",

author = "Ramsteijn, {A. S.} and {Van de Wijer}, L. and J. Rando and {van Luijk}, J. and Homberg, {J. R.} and Olivier, {J. D.A.}",

note = "Funding Information: This work was supported by a ZonMw grant (MKMD project; ID 114024127 ) awarded to JO & AR, and a grant awarded to JH from the Donders Institute for Brain, Cognition and Behavior . Funding bodies had no role in study design, data collection, data analysis, data interpretation, or the writing of the report. ",

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AU - Rando, J.

AU - van Luijk, J.

AU - Homberg, J. R.

AU - Olivier, J. D.A.

N1 - Funding Information: This work was supported by a ZonMw grant (MKMD project; ID 114024127 ) awarded to JO & AR, and a grant awarded to JH from the Donders Institute for Brain, Cognition and Behavior . Funding bodies had no role in study design, data collection, data analysis, data interpretation, or the writing of the report.

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N2 - In the Western world, 2–5 % of pregnant women use selective serotonin reuptake inhibitor (SSRI) antidepressants. There is no consensus on the potential long-term neurodevelopmental outcomes of early SSRI exposure. Our aim was to determine whether there is an overall effect of perinatal SSRI exposure in animals on a spectrum of behavioral domains. After a comprehensive database search in PubMed, PsycINFO, and Web of Science, we included 99 publications. We performed nine meta-analyses and two qualitative syntheses corresponding to different behavioral categories, aggregating data from thousands of animals. We found evidence for reduced activity and exploration behavior (standardized mean difference (SMD) −0.28 [−0.38, −0.18]), more passive stress coping (SMD −0.37 [−0.52, −0.23]), and less efficient sensory processing (SMD −0.37 [−0.69, −0.06]) in SSRI- versus vehicle-exposed animals. No differences were found for anxiety (p = 0.06), social behavior, learning and memory, ingestive- and reward behavior, motoric behavior, or reflex and pain sensitivity. Exposure in the period equivalent to the human third trimester was associated with the strongest effects.

AB - In the Western world, 2–5 % of pregnant women use selective serotonin reuptake inhibitor (SSRI) antidepressants. There is no consensus on the potential long-term neurodevelopmental outcomes of early SSRI exposure. Our aim was to determine whether there is an overall effect of perinatal SSRI exposure in animals on a spectrum of behavioral domains. After a comprehensive database search in PubMed, PsycINFO, and Web of Science, we included 99 publications. We performed nine meta-analyses and two qualitative syntheses corresponding to different behavioral categories, aggregating data from thousands of animals. We found evidence for reduced activity and exploration behavior (standardized mean difference (SMD) −0.28 [−0.38, −0.18]), more passive stress coping (SMD −0.37 [−0.52, −0.23]), and less efficient sensory processing (SMD −0.37 [−0.69, −0.06]) in SSRI- versus vehicle-exposed animals. No differences were found for anxiety (p = 0.06), social behavior, learning and memory, ingestive- and reward behavior, motoric behavior, or reflex and pain sensitivity. Exposure in the period equivalent to the human third trimester was associated with the strongest effects.

KW - Activity and exploration

KW - Animal studies

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KW - Anxiety

KW - Behavior

KW - Developmental exposure

KW - Ingestive and reward behavior

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KW - Meta-analysis

KW - Motoric behavior

KW - Offspring

KW - Pregnancy

KW - Reflex and pain sensitivity

KW - Selective serotonin reuptake inhibitors (SSRIs)

KW - Sensory processing

KW - Sleep and circadian activity

KW - Social behavior

KW - Stress coping

KW - Systematic review

KW - Teratogenic effects

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M3 - Review article

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AN - SCOPUS:85084346620

SN - 0149-7634

VL - 114

SP - 53

EP - 69

JO - Neuroscience and Biobehavioral Reviews

JF - Neuroscience and Biobehavioral Reviews

ER -

Perinatal selective serotonin reuptake inhibitor exposure and behavioral outcomes: A systematic review and meta-analyses of animal studies

Abstract

Bibliographical note

Keywords

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