Peripheral tissue-brain interactions in the regulation of food intake

Miguel López, Sulay Tovar, María J. Vázquez, Lynda M. Williams, Carlos Diéguez*

*Corresponding author for this work

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

More than 70 years ago the glucostatic, lipostatic and aminostatic hypotheses proposed that the central nervous system sensed circulating levels of different metabolites, changing feeding behaviour in response to the levels of those molecules. In the last 20 years the rapid increase in obesity and associated pathologies in developed countries has involved a substantial increase in the knowledge of the physiological and molecular mechanism regulating body mass. This effort has resulted in the recent discovery of new peripheral signals, such as leptin and ghrelin, as well as new neuropeptides, such as orexins, involved in body-weight homeostasis. The present review summarises research into energy balance, starting from the original classical hypotheses proposing metabolite sensing, through peripheral tissue-brain interactions and coming full circle to the recently-discovered role of hypothalamic fatty acid synthase in feeding regulation. Understanding these molecular mechanisms will provide new pharmacological targets for the treatment of obesity and appetite disorders.

Original languageEnglish
Pages (from-to)131-155
Number of pages25
JournalProceedings of the Nutrition Society
Volume66
Issue number1
DOIs
Publication statusPublished - 1 Feb 2007

Fingerprint

Appetite Regulation
food intake
obesity
Obesity
metabolites
brain
Fatty Acid Synthases
ghrelin
fatty-acid synthase
Ghrelin
eating disorders
neuropeptides
Brain
Feeding Behavior
Leptin
leptin
Neuropeptides
Developed Countries
developed countries
energy balance

Keywords

  • Adipose and pancreatic hormones
  • Food intake regulation
  • Gastrointestinal signals
  • Neural control

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

Cite this

López, M., Tovar, S., Vázquez, M. J., Williams, L. M., & Diéguez, C. (2007). Peripheral tissue-brain interactions in the regulation of food intake. Proceedings of the Nutrition Society, 66(1), 131-155. https://doi.org/10.1017/S0029665107005368

Peripheral tissue-brain interactions in the regulation of food intake. / López, Miguel; Tovar, Sulay; Vázquez, María J.; Williams, Lynda M.; Diéguez, Carlos.

In: Proceedings of the Nutrition Society, Vol. 66, No. 1, 01.02.2007, p. 131-155.

Research output: Contribution to journalArticle

López, M, Tovar, S, Vázquez, MJ, Williams, LM & Diéguez, C 2007, 'Peripheral tissue-brain interactions in the regulation of food intake', Proceedings of the Nutrition Society, vol. 66, no. 1, pp. 131-155. https://doi.org/10.1017/S0029665107005368
López, Miguel ; Tovar, Sulay ; Vázquez, María J. ; Williams, Lynda M. ; Diéguez, Carlos. / Peripheral tissue-brain interactions in the regulation of food intake. In: Proceedings of the Nutrition Society. 2007 ; Vol. 66, No. 1. pp. 131-155.
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