Persistent infection with human papillomavirus following the successful treatment of high grade cervical intraepithelial neoplasia

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Abstract

In a need case-control study, we identified women who were successfully treated for CIN 3. Cases had biopsy proven recurrence, whilst controls remained disease free for at least five years. One hundred and seventy-two women were P-globin positive at diagnostic and at six-month post-treatment smear (90 controls and 82 cases). Thirty-nine cases (47.6%) were HPV16/18 positive at biopsy or follow up smear and 14 (17.1%) of 82 were positive at both. Of the controls, 37 (41.1%) were HPV positive at biopsy or smear with (3.3%) positive at both. The unadjusted OR associated with being HPV positive at both points compared to being HPV negative at both was 8.0 (95% CI 2.13-30.37). The persistence of HPV 16/18 infection following the confirmed eradication of CIN is a highly significant risk factor for recurrence.

Original languageEnglish
Pages (from-to)579-581
Number of pages2
JournalBJOG-An International Journal of Obstetrics and Gynaecology
Volume109
Issue number5
DOIs
Publication statusPublished - 2002

Keywords

  • SMEARS
  • CANCER

Cite this

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title = "Persistent infection with human papillomavirus following the successful treatment of high grade cervical intraepithelial neoplasia",
abstract = "In a need case-control study, we identified women who were successfully treated for CIN 3. Cases had biopsy proven recurrence, whilst controls remained disease free for at least five years. One hundred and seventy-two women were P-globin positive at diagnostic and at six-month post-treatment smear (90 controls and 82 cases). Thirty-nine cases (47.6{\%}) were HPV16/18 positive at biopsy or follow up smear and 14 (17.1{\%}) of 82 were positive at both. Of the controls, 37 (41.1{\%}) were HPV positive at biopsy or smear with (3.3{\%}) positive at both. The unadjusted OR associated with being HPV positive at both points compared to being HPV negative at both was 8.0 (95{\%} CI 2.13-30.37). The persistence of HPV 16/18 infection following the confirmed eradication of CIN is a highly significant risk factor for recurrence.",
keywords = "SMEARS, CANCER",
author = "Cruickshank, {Margaret Eleanor} and Linda Sharp and Murray, {Graeme Ian} and Louise Smart",
year = "2002",
doi = "10.1111/j.1471-0528.2002.01554.x",
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volume = "109",
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journal = "BJOG-An International Journal of Obstetrics and Gynaecology",
issn = "1470-0328",
publisher = "John Wiley & Sons, Ltd (10.1111)",
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TY - JOUR

T1 - Persistent infection with human papillomavirus following the successful treatment of high grade cervical intraepithelial neoplasia

AU - Cruickshank, Margaret Eleanor

AU - Sharp, Linda

AU - Murray, Graeme Ian

AU - Smart, Louise

PY - 2002

Y1 - 2002

N2 - In a need case-control study, we identified women who were successfully treated for CIN 3. Cases had biopsy proven recurrence, whilst controls remained disease free for at least five years. One hundred and seventy-two women were P-globin positive at diagnostic and at six-month post-treatment smear (90 controls and 82 cases). Thirty-nine cases (47.6%) were HPV16/18 positive at biopsy or follow up smear and 14 (17.1%) of 82 were positive at both. Of the controls, 37 (41.1%) were HPV positive at biopsy or smear with (3.3%) positive at both. The unadjusted OR associated with being HPV positive at both points compared to being HPV negative at both was 8.0 (95% CI 2.13-30.37). The persistence of HPV 16/18 infection following the confirmed eradication of CIN is a highly significant risk factor for recurrence.

AB - In a need case-control study, we identified women who were successfully treated for CIN 3. Cases had biopsy proven recurrence, whilst controls remained disease free for at least five years. One hundred and seventy-two women were P-globin positive at diagnostic and at six-month post-treatment smear (90 controls and 82 cases). Thirty-nine cases (47.6%) were HPV16/18 positive at biopsy or follow up smear and 14 (17.1%) of 82 were positive at both. Of the controls, 37 (41.1%) were HPV positive at biopsy or smear with (3.3%) positive at both. The unadjusted OR associated with being HPV positive at both points compared to being HPV negative at both was 8.0 (95% CI 2.13-30.37). The persistence of HPV 16/18 infection following the confirmed eradication of CIN is a highly significant risk factor for recurrence.

KW - SMEARS

KW - CANCER

U2 - 10.1111/j.1471-0528.2002.01554.x

DO - 10.1111/j.1471-0528.2002.01554.x

M3 - Article

VL - 109

SP - 579

EP - 581

JO - BJOG-An International Journal of Obstetrics and Gynaecology

JF - BJOG-An International Journal of Obstetrics and Gynaecology

SN - 1470-0328

IS - 5

ER -