Personalised medicine in hypercholesterolaemia: the role of pharmacogenetics in statin therapy

Najmeh Ahangari, Mohammad Doosti, Majid Ghayour Mobarhan, Amirhossein Sahebkar, Gordon A. Ferns, Alireza Pasdar* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Statins are the first-line choice in Lipid-lowering therapy to reduce cardiovascular risk. In a continuous attempt to optimise treatment success, there is a need for additional research on genes and related molecular pathways that can determine the efficacy and toxicity of lipid-lowering drugs. Several variations within genes associated with lipid metabolism, including those involved in uptake, distribution and metabolism of statins have been reported. The purpose of this study was to evaluate the effect of genetic variations in the key genes responsible for statins’ metabolism and their role in personalised medicine and pharmacogenetic testing (PGx) in patients treated with such drugs. Genetic assessment for specific known SNPs within the most known genes such as ABCG2, SLCO1B1, CYP3A4, and HMGCR, appears likely to predict the efficacy of statin therapy and prevent their side effects but does not necessarily reduce the risk of cardiovascular events.
Original languageEnglish
Pages (from-to)462-470
Number of pages9
JournalAnnals of Medicine
Volume52
Issue number8
Early online date24 Aug 2020
DOIs
Publication statusE-pub ahead of print - 24 Aug 2020

Keywords

  • Statins
  • hypercholesterolaemia
  • personalised medicine
  • HMG-COA REDUCTASE
  • SLCO1B1 POLYMORPHISM
  • ACUTE CORONARY SYNDROMES
  • INDUCED MYOPATHY
  • BCRP GENE POLYMORPHISMS
  • HIGH-RISK PATIENTS
  • LDL-CHOLESTEROL LEVELS
  • LIPID-LOWERING RESPONSE
  • CARDIOVASCULAR-DISEASE
  • SINGLE NUCLEOTIDE POLYMORPHISMS

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    Ahangari, N., Doosti, M., Mobarhan, M. G., Sahebkar, A., Ferns, G. A., & Pasdar, A. (2020). Personalised medicine in hypercholesterolaemia: the role of pharmacogenetics in statin therapy. Annals of Medicine, 52(8), 462-470. https://doi.org/10.1080/07853890.2020.1800074