Pharmacogenetic analysis of GLCCI1 in three north European pediatric asthma populations with a reported use of inhaled corticosteroids

Susanne J H Vijverberg, Roger Tavendale, Maarten Leusink, Leo Koenderman, Jan A M Raaijmakers, Dirkje S Postma, Gerard H Koppelman, Steve W Turner, Somnath Mukhopadhyay, Colin N A Palmer, Anke Hilse Maitland-van der Zee, Stephen William Turner

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

BACKGROUND: GLCCI1 rs37972 has previously been associated with decreased lung function improvement upon treatment with inhaled corticosteroids (ICS) in asthmatics.

AIM: To assess whether variation in rs37972 is associated with altered ICS efficacy in north European asthmatic children and young adults with a reported use of ICS.

PATIENTS & METHODS: rs37972 was genotyped in three cohort studies of asthmatic children with a reported use of ICS. As an indicator for asthma exacerbations, asthma-related hospital visits and oral corticosteroid use were studied. Asthma control was assessed using a questionnaire.

RESULTS: rs37972 T allele was not significantly associated with an increased risk of oral corticosteroid use (summary odds ratio: 1.20; 95% CI: 0.99-1.45), an increased risk of asthma-related hospital visits (summary odds ratio: 1.07; 95% CI: 0.89-1.29), uncontrolled symptoms (summary odds ratio: 1.01; 95% CI: 0.75-1.36) or higher ICS dosages (summary β: 0.01, 95% CI: -0.06-0.08).

CONCLUSION: Variation in GLCCI1 rs37972 genotype does not seem to affect ICS efficacy in north European asthmatic children. Original submitted 26 November 2013; Revision submitted 13 February 2014.

Original languageEnglish
Pages (from-to)799-806
Number of pages8
JournalThe Pharmacogenomics Journal
Volume15
Issue number6
DOIs
Publication statusPublished - Apr 2014

Keywords

  • Administration, Inhalation
  • Adolescent
  • Adrenal Cortex Hormones
  • Adult
  • Anti-Asthmatic Agents
  • Asthma
  • Child
  • Child, Preschool
  • Cohort Studies
  • European Continental Ancestry Group
  • Humans
  • Pediatrics
  • Pharmacogenetics
  • Receptors, Glucocorticoid
  • Young Adult

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