Pharmacogenetic analysis of GLCCI1 in three north European pediatric asthma populations with a reported use of inhaled corticosteroids

Susanne J H Vijverberg, Roger Tavendale, Maarten Leusink, Leo Koenderman, Jan A M Raaijmakers, Dirkje S Postma, Gerard H Koppelman, Steve W Turner, Somnath Mukhopadhyay, Colin N A Palmer, Anke Hilse Maitland-van der Zee, Stephen William Turner

Research output: Contribution to journalArticle

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Abstract

BACKGROUND: GLCCI1 rs37972 has previously been associated with decreased lung function improvement upon treatment with inhaled corticosteroids (ICS) in asthmatics.

AIM: To assess whether variation in rs37972 is associated with altered ICS efficacy in north European asthmatic children and young adults with a reported use of ICS.

PATIENTS & METHODS: rs37972 was genotyped in three cohort studies of asthmatic children with a reported use of ICS. As an indicator for asthma exacerbations, asthma-related hospital visits and oral corticosteroid use were studied. Asthma control was assessed using a questionnaire.

RESULTS: rs37972 T allele was not significantly associated with an increased risk of oral corticosteroid use (summary odds ratio: 1.20; 95% CI: 0.99-1.45), an increased risk of asthma-related hospital visits (summary odds ratio: 1.07; 95% CI: 0.89-1.29), uncontrolled symptoms (summary odds ratio: 1.01; 95% CI: 0.75-1.36) or higher ICS dosages (summary β: 0.01, 95% CI: -0.06-0.08).

CONCLUSION: Variation in GLCCI1 rs37972 genotype does not seem to affect ICS efficacy in north European asthmatic children. Original submitted 26 November 2013; Revision submitted 13 February 2014.

Original languageEnglish
Pages (from-to)799-806
Number of pages8
JournalThe Pharmacogenomics Journal
Volume15
Issue number6
DOIs
Publication statusPublished - Apr 2014

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Adrenal Cortex Hormones
Asthma
Pediatrics
Population
Odds Ratio
Pharmacogenomic Testing
Young Adult
Cohort Studies
Alleles
Genotype
Lung

Keywords

  • Administration, Inhalation
  • Adolescent
  • Adrenal Cortex Hormones
  • Adult
  • Anti-Asthmatic Agents
  • Asthma
  • Child
  • Child, Preschool
  • Cohort Studies
  • European Continental Ancestry Group
  • Humans
  • Pediatrics
  • Pharmacogenetics
  • Receptors, Glucocorticoid
  • Young Adult

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Pharmacogenetic analysis of GLCCI1 in three north European pediatric asthma populations with a reported use of inhaled corticosteroids. / Vijverberg, Susanne J H; Tavendale, Roger; Leusink, Maarten; Koenderman, Leo; Raaijmakers, Jan A M; Postma, Dirkje S; Koppelman, Gerard H; Turner, Steve W; Mukhopadhyay, Somnath; Palmer, Colin N A; Maitland-van der Zee, Anke Hilse; Turner, Stephen William.

In: The Pharmacogenomics Journal, Vol. 15, No. 6, 04.2014, p. 799-806.

Research output: Contribution to journalArticle

Vijverberg, SJH, Tavendale, R, Leusink, M, Koenderman, L, Raaijmakers, JAM, Postma, DS, Koppelman, GH, Turner, SW, Mukhopadhyay, S, Palmer, CNA, Maitland-van der Zee, AH & Turner, SW 2014, 'Pharmacogenetic analysis of GLCCI1 in three north European pediatric asthma populations with a reported use of inhaled corticosteroids', The Pharmacogenomics Journal, vol. 15, no. 6, pp. 799-806. https://doi.org/10.2217/pgs.14.37
Vijverberg, Susanne J H ; Tavendale, Roger ; Leusink, Maarten ; Koenderman, Leo ; Raaijmakers, Jan A M ; Postma, Dirkje S ; Koppelman, Gerard H ; Turner, Steve W ; Mukhopadhyay, Somnath ; Palmer, Colin N A ; Maitland-van der Zee, Anke Hilse ; Turner, Stephen William. / Pharmacogenetic analysis of GLCCI1 in three north European pediatric asthma populations with a reported use of inhaled corticosteroids. In: The Pharmacogenomics Journal. 2014 ; Vol. 15, No. 6. pp. 799-806.
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abstract = "BACKGROUND: GLCCI1 rs37972 has previously been associated with decreased lung function improvement upon treatment with inhaled corticosteroids (ICS) in asthmatics.AIM: To assess whether variation in rs37972 is associated with altered ICS efficacy in north European asthmatic children and young adults with a reported use of ICS.PATIENTS & METHODS: rs37972 was genotyped in three cohort studies of asthmatic children with a reported use of ICS. As an indicator for asthma exacerbations, asthma-related hospital visits and oral corticosteroid use were studied. Asthma control was assessed using a questionnaire.RESULTS: rs37972 T allele was not significantly associated with an increased risk of oral corticosteroid use (summary odds ratio: 1.20; 95{\%} CI: 0.99-1.45), an increased risk of asthma-related hospital visits (summary odds ratio: 1.07; 95{\%} CI: 0.89-1.29), uncontrolled symptoms (summary odds ratio: 1.01; 95{\%} CI: 0.75-1.36) or higher ICS dosages (summary β: 0.01, 95{\%} CI: -0.06-0.08).CONCLUSION: Variation in GLCCI1 rs37972 genotype does not seem to affect ICS efficacy in north European asthmatic children. Original submitted 26 November 2013; Revision submitted 13 February 2014.",
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T1 - Pharmacogenetic analysis of GLCCI1 in three north European pediatric asthma populations with a reported use of inhaled corticosteroids

AU - Vijverberg, Susanne J H

AU - Tavendale, Roger

AU - Leusink, Maarten

AU - Koenderman, Leo

AU - Raaijmakers, Jan A M

AU - Postma, Dirkje S

AU - Koppelman, Gerard H

AU - Turner, Steve W

AU - Mukhopadhyay, Somnath

AU - Palmer, Colin N A

AU - Maitland-van der Zee, Anke Hilse

AU - Turner, Stephen William

PY - 2014/4

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N2 - BACKGROUND: GLCCI1 rs37972 has previously been associated with decreased lung function improvement upon treatment with inhaled corticosteroids (ICS) in asthmatics.AIM: To assess whether variation in rs37972 is associated with altered ICS efficacy in north European asthmatic children and young adults with a reported use of ICS.PATIENTS & METHODS: rs37972 was genotyped in three cohort studies of asthmatic children with a reported use of ICS. As an indicator for asthma exacerbations, asthma-related hospital visits and oral corticosteroid use were studied. Asthma control was assessed using a questionnaire.RESULTS: rs37972 T allele was not significantly associated with an increased risk of oral corticosteroid use (summary odds ratio: 1.20; 95% CI: 0.99-1.45), an increased risk of asthma-related hospital visits (summary odds ratio: 1.07; 95% CI: 0.89-1.29), uncontrolled symptoms (summary odds ratio: 1.01; 95% CI: 0.75-1.36) or higher ICS dosages (summary β: 0.01, 95% CI: -0.06-0.08).CONCLUSION: Variation in GLCCI1 rs37972 genotype does not seem to affect ICS efficacy in north European asthmatic children. Original submitted 26 November 2013; Revision submitted 13 February 2014.

AB - BACKGROUND: GLCCI1 rs37972 has previously been associated with decreased lung function improvement upon treatment with inhaled corticosteroids (ICS) in asthmatics.AIM: To assess whether variation in rs37972 is associated with altered ICS efficacy in north European asthmatic children and young adults with a reported use of ICS.PATIENTS & METHODS: rs37972 was genotyped in three cohort studies of asthmatic children with a reported use of ICS. As an indicator for asthma exacerbations, asthma-related hospital visits and oral corticosteroid use were studied. Asthma control was assessed using a questionnaire.RESULTS: rs37972 T allele was not significantly associated with an increased risk of oral corticosteroid use (summary odds ratio: 1.20; 95% CI: 0.99-1.45), an increased risk of asthma-related hospital visits (summary odds ratio: 1.07; 95% CI: 0.89-1.29), uncontrolled symptoms (summary odds ratio: 1.01; 95% CI: 0.75-1.36) or higher ICS dosages (summary β: 0.01, 95% CI: -0.06-0.08).CONCLUSION: Variation in GLCCI1 rs37972 genotype does not seem to affect ICS efficacy in north European asthmatic children. Original submitted 26 November 2013; Revision submitted 13 February 2014.

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KW - Adrenal Cortex Hormones

KW - Adult

KW - Anti-Asthmatic Agents

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KW - Child

KW - Child, Preschool

KW - Cohort Studies

KW - European Continental Ancestry Group

KW - Humans

KW - Pediatrics

KW - Pharmacogenetics

KW - Receptors, Glucocorticoid

KW - Young Adult

U2 - 10.2217/pgs.14.37

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JF - The Pharmacogenomics Journal

SN - 1470-269X

IS - 6

ER -