Pharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritisation

Charlotte King, Amanda McKenna, Niloufar Farzan, Susanne J. Vijverberg, Marc P. van der Schee, Anke H. Maitland-van der Zee, Lambang Arianto, Hans Bisgaard, Klaus BØnnelykke, Vojko Berce, Uroš Potočnik, Katja Repnik, Bruce Carleton, Denise Daley, Fook Tim Chew, Wen Chin Chiang, Yang Yie Sio, Michelle M. Cloutier, Herman T. Den Dekker, Liesbeth DuijtsJohan C. de Jongste, F. Nicole Dijk, Gerard H. Koppelman, Carlos Flores, Natalia Hernandez-Pacheco, Maria Pino-Yanes, Somnath Mukhopadhyay, Kaninika Basu, Lauren Bignell, Kelan G. Tantisira, Steve Turner, Katia M. Verhamme, Ben Francis, Munir Pirmohamed, Ian Sinha, Daniel B. Hawcutt*

*Corresponding author for this work

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Abstract

A systematic review of pharmacogenomic studies capturing adverse drug reactions (ADRs) related to asthma medications was undertaken, and a survey of Pharmacogenomics in Childhood Asthma (PiCA) consortia members was conducted. Studies were eligible if genetic polymorphisms were compared with suspected ADR(s) in a patient with asthma, as either a primary or secondary outcome. Five studies met the inclusion criteria. The ADRs and polymorphisms identified were change in lung function tests (rs1042713), adrenal suppression (rs591118), and decreased bone mineral density (rs6461639) and accretion (rs9896933, rs2074439). Two of these polymorphisms were replicated within the paper, but none had external replication. Priorities from PiCA consortia members (representing 15 institution in eight countries) for future studies were tachycardia (SABA/LABA), adrenal suppression/crisis and growth suppression (corticosteroids), sleep/behaviour disturbances (leukotriene receptor antagonists), and nausea and vomiting (theophylline). Future pharmacogenomic studies in asthma should collect relevant ADR data as well as markers of efficacy.

Original languageEnglish
Number of pages8
JournalPharmacogenomics Journal
Early online date17 Jan 2020
DOIs
Publication statusE-pub ahead of print - 17 Jan 2020

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Keywords

  • CHILDREN
  • EXACERBATIONS
  • RISK
  • POLYMORPHISM
  • BURDEN

ASJC Scopus subject areas

  • Genetics
  • Molecular Medicine
  • Pharmacology

Cite this

King, C., McKenna, A., Farzan, N., Vijverberg, S. J., van der Schee, M. P., Maitland-van der Zee, A. H., Arianto, L., Bisgaard, H., BØnnelykke, K., Berce, V., Potočnik, U., Repnik, K., Carleton, B., Daley, D., Chew, F. T., Chiang, W. C., Sio, Y. Y., Cloutier, M. M., Den Dekker, H. T., ... Hawcutt, D. B. (2020). Pharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritisation. Pharmacogenomics Journal. https://doi.org/10.1038/s41397-019-0140-y