Pharmacokinetic assessment of novel anti-cancer drugs using spectral analysis and positron emission tomography: a feasibility study

S R Meikle, J C Matthews, C S Brock, P Wells, R J Harte, V J Cunningham, T Jones, P Price

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

The aim of this study was to investigate the feasibility of evaluating the pharmacokinetics of radiolabeled anti-cancer drugs using spectral analysis, a non-compartmental tracer kinetic modeling technique, and positron emission tomography (PET).
Original languageEnglish
Pages (from-to)183-93
Number of pages11
JournalCancer Chemotherapy and Pharmacology
Volume42
Issue number3
Publication statusPublished - 1998

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Positron emission tomography
Pharmacokinetics
Feasibility Studies
Positron-Emission Tomography
Spectrum analysis
Kinetics
Pharmaceutical Preparations
Neoplasms

Keywords

  • Acridines
  • Antimetabolites, Antineoplastic
  • Antineoplastic Agents, Alkylating
  • Colorectal Neoplasms
  • Dacarbazine
  • Feasibility Studies
  • Female
  • Fluorouracil
  • Glioma
  • Humans
  • Middle Aged
  • Spectrum Analysis
  • Tomography, Emission-Computed

Cite this

Meikle, S. R., Matthews, J. C., Brock, C. S., Wells, P., Harte, R. J., Cunningham, V. J., ... Price, P. (1998). Pharmacokinetic assessment of novel anti-cancer drugs using spectral analysis and positron emission tomography: a feasibility study. Cancer Chemotherapy and Pharmacology, 42(3), 183-93.

Pharmacokinetic assessment of novel anti-cancer drugs using spectral analysis and positron emission tomography: a feasibility study. / Meikle, S R; Matthews, J C; Brock, C S; Wells, P; Harte, R J; Cunningham, V J; Jones, T; Price, P.

In: Cancer Chemotherapy and Pharmacology, Vol. 42, No. 3, 1998, p. 183-93.

Research output: Contribution to journalArticle

Meikle, SR, Matthews, JC, Brock, CS, Wells, P, Harte, RJ, Cunningham, VJ, Jones, T & Price, P 1998, 'Pharmacokinetic assessment of novel anti-cancer drugs using spectral analysis and positron emission tomography: a feasibility study', Cancer Chemotherapy and Pharmacology, vol. 42, no. 3, pp. 183-93.
Meikle, S R ; Matthews, J C ; Brock, C S ; Wells, P ; Harte, R J ; Cunningham, V J ; Jones, T ; Price, P. / Pharmacokinetic assessment of novel anti-cancer drugs using spectral analysis and positron emission tomography: a feasibility study. In: Cancer Chemotherapy and Pharmacology. 1998 ; Vol. 42, No. 3. pp. 183-93.
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