Pharmacologic profile of zoledronic acid: A highly potent inhibitor of bone resorption

J R Green, M J Rogers

Research output: Contribution to journalLiterature reviewpeer-review

99 Citations (Scopus)

Abstract

Bisphosphonates are effective in treating benign and malignant skeletal diseases characterized by enhanced osteoclastic bone resorption (i.e., osteoporosis, Paget's disease, tumor-induced osteolysis). The nitrogen-containing bisphosphonate pamidronate is currently the standard treatment for hypercalcemia of malignancy (HCM) and skeletal complications of bone metastases. Zoledronic acid, a novel nitrogen-containing bisphosphonate with an imidazole substituent, has demonstrated more potent inhibition of osteoclast-mediated bone resorption than all other bisphosphonates, including pamidronate, in both in vitro and in vivo preclinical models. Zoledronic acid inhibited ovariectomy-induced bone loss in adult monkeys and rats, and long-term treatment prevented skeletal turnover and subsequent bone loss, reduced cortical porosity, and increased mechanical strength. Zoledronic acid also significantly inhibited bone loss associated with arthritis, bone metastases, and prosthesis loosening. The increased potency of zoledronic acid vs. pamidronate has been demonstrated clinically: zoledronic acid (4 or 8 mg iv) was superior to pamidronate (90 mg iv) in normalizing corrected serum calcium in patients with HCM. In patients with bone metastases, low doses of zoledronic acid (less than or equal to 2 mg) suppressed bone resorption markers less than or equal to 50% below baseline, whereas pamidronate 90 mg yielded only 20 to 30% Suppression. Importantly, the increased potency of zoledronic acid is not associated with an increased incidence of local (bone) or systemic adverse events. Zoledronic acid does not impair bone mineralization and, compared with pamidronate, has a greater renal and intestinal tolerability therapeutic index. Thus, based on preclinical assays and clinical data, zoledronic acid is the most potent bisphosphonate tested to date. Given its potency and excellent safety profile, zoledronic acid is now poised to become the new standard of treatment for HCM and metastatic bone disease.

Original languageEnglish
Pages (from-to)210-224
Number of pages15
JournalDrug Development Research
Volume55
DOIs
Publication statusPublished - 2002

Keywords

  • zoledronic acid
  • bisphosphonate
  • pamidronate
  • bone resorption
  • hypercalcernia of malignancy
  • NITROGEN-CONTAINING BISPHOSPHONATES
  • MOLD DICTYOSTELIUM-DISCOIDEUM
  • CELLS IN-VITRO
  • FARNESYL DIPHOSPHATE SYNTHASE
  • ADVANCED MULTIPLE-MYELOMA
  • BREAST-CANCER
  • SKELETAL COMPLICATIONS
  • MEVALONATE PATHWAY
  • INFLAMMATORY ARTHRITIS
  • CONTROLLED TRIAL

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