Pharmacological and other interventions for head and neck cancer pain

a systematic review

Patrick B Trotter, Lindsey A Norton, Ann S Loo, Jonathan I Munn, Elena Voge, Kim W Ah-See, Tatiana MacFarlane

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: Pain is a common complication in head and neck cancer. The aim of this paper is to evaluate the evidence from randomised control trials investigating pharmacological and non-pharmacological methods of pain management in head and neck cancer.

MATERIAL AND METHODS: Medline, Embase and the Cochrane library databases were searched. Squamous cell carcinomas of the head and neck excluding nasopharyngeal and salivary gland cancers were included. The limits were "human" and "randomised clinical trials". A quality assessment was carried out.

RESULTS: 13 studies were included with a total of 644 participants. The primary outcome for most of these papers was pain control post-treatment. Levels of bias varied between the studies. Majority (12 out of the 13 studies) reported intervention to be superior to the control or standard therapy in pain management. Only 46% of the studies were carried out on an intention to treat basis. Two studies reported high dropout rates, with one at 66%.

CONCLUSIONS: There is insufficient evidence from randomised clinical trials to suggest an optimal pharmacological intervention for head and neck cancer pain post-treatment. Further high quality randomised clinical trials should be conducted to develop an optimal management strategy for head and neck cancer pain.

Original languageEnglish
Pages (from-to)e1
Number of pages1
JournalJournal of Oral & Maxillofacial Research
Volume3
Issue number4
DOIs
Publication statusPublished - 2013

Fingerprint

Neck Pain
Head and Neck Neoplasms
Pharmacology
Randomized Controlled Trials
Pain Management
Salivary Gland Neoplasms
Pain
Libraries
Therapeutics
Databases
Cancer Pain

Keywords

  • head and neck neoplasms
  • pain
  • postoperative
  • analgesics
  • opioid
  • pain measurement
  • systematic review

Cite this

Pharmacological and other interventions for head and neck cancer pain : a systematic review. / Trotter, Patrick B; Norton, Lindsey A; Loo, Ann S; Munn, Jonathan I; Voge, Elena; Ah-See, Kim W; MacFarlane, Tatiana.

In: Journal of Oral & Maxillofacial Research, Vol. 3, No. 4, 2013, p. e1.

Research output: Contribution to journalArticle

Trotter, Patrick B ; Norton, Lindsey A ; Loo, Ann S ; Munn, Jonathan I ; Voge, Elena ; Ah-See, Kim W ; MacFarlane, Tatiana. / Pharmacological and other interventions for head and neck cancer pain : a systematic review. In: Journal of Oral & Maxillofacial Research. 2013 ; Vol. 3, No. 4. pp. e1.
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AU - Trotter, Patrick B

AU - Norton, Lindsey A

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AU - Voge, Elena

AU - Ah-See, Kim W

AU - MacFarlane, Tatiana

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