Pharmacological blood pressure lowering in the older hypertensive patients may lead to cognitive impairment by altering neurovascular coupling

Yasir A Alrawi, Ronney B Panerai, Phyo Kyaw Myint, John F Potter

Research output: Contribution to journalComment/debate

9 Citations (Scopus)

Abstract

The link between both high and low blood pressure (BP) levels and cognitive impairment in later life has been reported in several studies. The mechanisms for this link are unclear but may be related to abnormalities in brain blood flow control. Our previous work has shown that cerebral autoregulation (CA) is unimpaired in both young and older people with hypertension at rest and that ageing does not appear to impact on the increase in the cerebral blood flow response to increased metabolic demand of neurones and other cells of the nervous system due to heightened activity (Neurovascular Coupling, NVC). Nonetheless, it is plausible that NVC efficiency becomes compromised during mental activity in older people with hypertension and that certain classes of anti-hypertensive agents may exacerbate the situation by reducing both NVC and CA contributing to cognitive decline. Such a link would have a major impact on prescribing patterns for anti-hypertensive medication.
Original languageEnglish
Pages (from-to)303-307
Number of pages5
JournalMedical hypotheses
Volume80
Issue number3
DOIs
Publication statusPublished - Mar 2013

Fingerprint

Pharmacology
Blood Pressure
Hypertension
Antihypertensive Agents
Cerebrovascular Circulation
Homeostasis
Hypotension
Nervous System
Neurons
Brain
Cognitive Dysfunction
Neurovascular Coupling

Keywords

  • antihypertensive agents
  • blood pressure
  • cerebrovascular circulation
  • cognition disorders
  • humans
  • hypertension
  • models, theoretical

Cite this

Pharmacological blood pressure lowering in the older hypertensive patients may lead to cognitive impairment by altering neurovascular coupling. / Alrawi, Yasir A; Panerai, Ronney B; Myint, Phyo Kyaw; Potter, John F.

In: Medical hypotheses, Vol. 80, No. 3, 03.2013, p. 303-307.

Research output: Contribution to journalComment/debate

@article{d11f5da2cde548fa9562164c3c191bf1,
title = "Pharmacological blood pressure lowering in the older hypertensive patients may lead to cognitive impairment by altering neurovascular coupling",
abstract = "The link between both high and low blood pressure (BP) levels and cognitive impairment in later life has been reported in several studies. The mechanisms for this link are unclear but may be related to abnormalities in brain blood flow control. Our previous work has shown that cerebral autoregulation (CA) is unimpaired in both young and older people with hypertension at rest and that ageing does not appear to impact on the increase in the cerebral blood flow response to increased metabolic demand of neurones and other cells of the nervous system due to heightened activity (Neurovascular Coupling, NVC). Nonetheless, it is plausible that NVC efficiency becomes compromised during mental activity in older people with hypertension and that certain classes of anti-hypertensive agents may exacerbate the situation by reducing both NVC and CA contributing to cognitive decline. Such a link would have a major impact on prescribing patterns for anti-hypertensive medication.",
keywords = "antihypertensive agents, blood pressure, cerebrovascular circulation, cognition disorders, humans, hypertension, models, theoretical",
author = "Alrawi, {Yasir A} and Panerai, {Ronney B} and Myint, {Phyo Kyaw} and Potter, {John F}",
note = "Copyright {\circledC} 2012 Elsevier Ltd. All rights reserved.",
year = "2013",
month = "3",
doi = "10.1016/j.mehy.2012.12.010",
language = "English",
volume = "80",
pages = "303--307",
journal = "Medical hypotheses",
issn = "1532-2777",
publisher = "Churchill Livingstone",
number = "3",

}

TY - JOUR

T1 - Pharmacological blood pressure lowering in the older hypertensive patients may lead to cognitive impairment by altering neurovascular coupling

AU - Alrawi, Yasir A

AU - Panerai, Ronney B

AU - Myint, Phyo Kyaw

AU - Potter, John F

N1 - Copyright © 2012 Elsevier Ltd. All rights reserved.

PY - 2013/3

Y1 - 2013/3

N2 - The link between both high and low blood pressure (BP) levels and cognitive impairment in later life has been reported in several studies. The mechanisms for this link are unclear but may be related to abnormalities in brain blood flow control. Our previous work has shown that cerebral autoregulation (CA) is unimpaired in both young and older people with hypertension at rest and that ageing does not appear to impact on the increase in the cerebral blood flow response to increased metabolic demand of neurones and other cells of the nervous system due to heightened activity (Neurovascular Coupling, NVC). Nonetheless, it is plausible that NVC efficiency becomes compromised during mental activity in older people with hypertension and that certain classes of anti-hypertensive agents may exacerbate the situation by reducing both NVC and CA contributing to cognitive decline. Such a link would have a major impact on prescribing patterns for anti-hypertensive medication.

AB - The link between both high and low blood pressure (BP) levels and cognitive impairment in later life has been reported in several studies. The mechanisms for this link are unclear but may be related to abnormalities in brain blood flow control. Our previous work has shown that cerebral autoregulation (CA) is unimpaired in both young and older people with hypertension at rest and that ageing does not appear to impact on the increase in the cerebral blood flow response to increased metabolic demand of neurones and other cells of the nervous system due to heightened activity (Neurovascular Coupling, NVC). Nonetheless, it is plausible that NVC efficiency becomes compromised during mental activity in older people with hypertension and that certain classes of anti-hypertensive agents may exacerbate the situation by reducing both NVC and CA contributing to cognitive decline. Such a link would have a major impact on prescribing patterns for anti-hypertensive medication.

KW - antihypertensive agents

KW - blood pressure

KW - cerebrovascular circulation

KW - cognition disorders

KW - humans

KW - hypertension

KW - models, theoretical

U2 - 10.1016/j.mehy.2012.12.010

DO - 10.1016/j.mehy.2012.12.010

M3 - Comment/debate

C2 - 23313333

VL - 80

SP - 303

EP - 307

JO - Medical hypotheses

JF - Medical hypotheses

SN - 1532-2777

IS - 3

ER -