Pharmacological studies of performance on the free-operant psychophysical procedure

S Body, T H C Cheung, L Valencia-Torres, C M Olarte Sanchez, K C F Fone, C M Bradshaw, E Szabadi

Research output: Contribution to journalArticle

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Abstract

In the free-operant psychophysical procedure (FOPP), reinforcement is provided intermittently for responding on lever A in the first half and lever B in the second half of a trial. Temporal differentiation is measured from the psychometric function (percent responding on B, %B, versus time from trial onset, t), the index of timing being T50, the value of t at %B=50. T50 is reduced by acute treatment with 5-hydroxytryptamine (5-HT1A, 5-HT2A) and dopamine (D1-like, D2-like) receptor agonists. The effects of the agonists can be reversed by the respective antagonists of these receptors. Evidence is reviewed suggesting that the effect of endogenous 5-HT is mediated by 5-HT2A receptors and the effect of endogenous dopamine by D1-like receptors. Data are presented on the effects of lesions of the prefrontal cortex and corpus striatum on the sensitivity of performance on the FOPP to D1-like and D2-like receptor agonists. Lesions of the nucleus accumbens, but not the dorsal striatum or prefrontal cortex, attenuated the effects of a D1-like receptor agonist, 6-chloro-2,3,4,5-tetrahydro-1-phenyl-1H-3-benzazepine [SKF-81297], but not a D2-like receptor agonist, quinpirole, on T50. The results indicate that a population of D1-like receptors in the ventral striatum may contribute to the control of timing performance on the FOPP.
Original languageEnglish
Pages (from-to)71-89
Number of pages19
JournalBehavioural Processes
Volume95
DOIs
Publication statusPublished - May 2013

Fingerprint

Pharmacology
Prefrontal Cortex
receptors
agonists
Serotonin
Benzazepines
Quinpirole
Corpus Striatum
Receptor, Serotonin, 5-HT2A
Dopamine D1 Receptors
Nucleus Accumbens
Psychometrics
Dopamine
dopamine
serotonin
Population
antagonists
Ventral Striatum
Reinforcement (Psychology)
SK&F 81297

Keywords

  • interval timing
  • free-operant psychophysical procedure
  • 5-HT receptors
  • dopamine receptors
  • prefrontal cortex
  • corpus striatum

Cite this

Body, S., Cheung, T. H. C., Valencia-Torres, L., Olarte Sanchez, C. M., Fone, K. C. F., Bradshaw, C. M., & Szabadi, E. (2013). Pharmacological studies of performance on the free-operant psychophysical procedure. Behavioural Processes, 95, 71-89. https://doi.org/10.1016/j.beproc.2013.02.004

Pharmacological studies of performance on the free-operant psychophysical procedure. / Body, S; Cheung, T H C; Valencia-Torres, L; Olarte Sanchez, C M; Fone, K C F; Bradshaw, C M; Szabadi, E.

In: Behavioural Processes, Vol. 95, 05.2013, p. 71-89.

Research output: Contribution to journalArticle

Body, S, Cheung, THC, Valencia-Torres, L, Olarte Sanchez, CM, Fone, KCF, Bradshaw, CM & Szabadi, E 2013, 'Pharmacological studies of performance on the free-operant psychophysical procedure', Behavioural Processes, vol. 95, pp. 71-89. https://doi.org/10.1016/j.beproc.2013.02.004
Body S, Cheung THC, Valencia-Torres L, Olarte Sanchez CM, Fone KCF, Bradshaw CM et al. Pharmacological studies of performance on the free-operant psychophysical procedure. Behavioural Processes. 2013 May;95:71-89. https://doi.org/10.1016/j.beproc.2013.02.004
Body, S ; Cheung, T H C ; Valencia-Torres, L ; Olarte Sanchez, C M ; Fone, K C F ; Bradshaw, C M ; Szabadi, E. / Pharmacological studies of performance on the free-operant psychophysical procedure. In: Behavioural Processes. 2013 ; Vol. 95. pp. 71-89.
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