Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 71-89 |
| Number of pages | 19 |
| Journal | Behavioural Processes |
| Volume | 95 |
| DOIs | |
| Publication status | Published - May 2013 |
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Keywords
- interval timing
- free-operant psychophysical procedure
- 5-HT receptors
- dopamine receptors
- prefrontal cortex
- corpus striatum
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Pharmacological studies of performance on the free-operant psychophysical procedure. / Body, S; Cheung, T H C; Valencia-Torres, L; Olarte Sanchez, C M; Fone, K C F; Bradshaw, C M; Szabadi, E.
In: Behavioural Processes, Vol. 95, 05.2013, p. 71-89.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Pharmacological studies of performance on the free-operant psychophysical procedure
AU - Body, S
AU - Cheung, T H C
AU - Valencia-Torres, L
AU - Olarte Sanchez, C M
AU - Fone, K C F
AU - Bradshaw, C M
AU - Szabadi, E
N1 - Copyright © 2013 Elsevier B.V. All rights reserved.
PY - 2013/5
Y1 - 2013/5
N2 - In the free-operant psychophysical procedure (FOPP), reinforcement is provided intermittently for responding on lever A in the first half and lever B in the second half of a trial. Temporal differentiation is measured from the psychometric function (percent responding on B, %B, versus time from trial onset, t), the index of timing being T50, the value of t at %B=50. T50 is reduced by acute treatment with 5-hydroxytryptamine (5-HT1A, 5-HT2A) and dopamine (D1-like, D2-like) receptor agonists. The effects of the agonists can be reversed by the respective antagonists of these receptors. Evidence is reviewed suggesting that the effect of endogenous 5-HT is mediated by 5-HT2A receptors and the effect of endogenous dopamine by D1-like receptors. Data are presented on the effects of lesions of the prefrontal cortex and corpus striatum on the sensitivity of performance on the FOPP to D1-like and D2-like receptor agonists. Lesions of the nucleus accumbens, but not the dorsal striatum or prefrontal cortex, attenuated the effects of a D1-like receptor agonist, 6-chloro-2,3,4,5-tetrahydro-1-phenyl-1H-3-benzazepine [SKF-81297], but not a D2-like receptor agonist, quinpirole, on T50. The results indicate that a population of D1-like receptors in the ventral striatum may contribute to the control of timing performance on the FOPP.
AB - In the free-operant psychophysical procedure (FOPP), reinforcement is provided intermittently for responding on lever A in the first half and lever B in the second half of a trial. Temporal differentiation is measured from the psychometric function (percent responding on B, %B, versus time from trial onset, t), the index of timing being T50, the value of t at %B=50. T50 is reduced by acute treatment with 5-hydroxytryptamine (5-HT1A, 5-HT2A) and dopamine (D1-like, D2-like) receptor agonists. The effects of the agonists can be reversed by the respective antagonists of these receptors. Evidence is reviewed suggesting that the effect of endogenous 5-HT is mediated by 5-HT2A receptors and the effect of endogenous dopamine by D1-like receptors. Data are presented on the effects of lesions of the prefrontal cortex and corpus striatum on the sensitivity of performance on the FOPP to D1-like and D2-like receptor agonists. Lesions of the nucleus accumbens, but not the dorsal striatum or prefrontal cortex, attenuated the effects of a D1-like receptor agonist, 6-chloro-2,3,4,5-tetrahydro-1-phenyl-1H-3-benzazepine [SKF-81297], but not a D2-like receptor agonist, quinpirole, on T50. The results indicate that a population of D1-like receptors in the ventral striatum may contribute to the control of timing performance on the FOPP.
KW - interval timing
KW - free-operant psychophysical procedure
KW - 5-HT receptors
KW - dopamine receptors
KW - prefrontal cortex
KW - corpus striatum
U2 - 10.1016/j.beproc.2013.02.004
DO - 10.1016/j.beproc.2013.02.004
M3 - Article
C2 - 23428704
VL - 95
SP - 71
EP - 89
JO - Behavioural Processes
JF - Behavioural Processes
SN - 0376-6357
ER -