Phased-array combination of 2D MRS for lipid composition quantification in patients with breast cancer

Vasiliki Mallikourti* (Corresponding Author), Sai Man Cheung, Tanja Gagliardi, Nicholas Senn, Yazan Masannat, Trevor McGordlrick, Ravi Sharma, Steven D. Heys, Jiabao He

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Lipid composition in breast cancer, a central marker of disease progression, can be noninvasively quantified using 2D MRS method of double quantum filtered correlation spectroscopy (DQF-COSY). The low signal to noise ratio (SNR), arising from signal retention of only 25% and depleted lipids within tumour, demands improvement approaches beyond signal averaging for clinically viable applications. We therefore adapted and examined combination algorithms, designed for 1D MRS, for 2D MRS with both internal and external
references. Lipid composition spectra were acquired from 17 breast tumour specimens, 15 healthy female volunteers and 25 patients with breast cancer on a clinical 3T MRI scanner. Whitened singular value decomposition (WSVD) with internal reference yielded maximal SNR with an improvement of 53.3%(40.3-106.9%) in specimens, 84.4±40.6% in volunteers, 96.9±54.2% in peritumoural adipose tissue and 52.4%(25.1-108.0%) in tumours in vivo. Non-uniformity, as variance of improvement across peaks, was low at 21.1%(13.7-28.1%) in specimens, 5.5%(4.2-7.2%) in volunteers, 6.1%(5.0-9.0%) in peritumoural tissue, and 20.7%(17.4-31.7%) in tumours in vivo. The bias (slope) in improvement ranged from -1.08 to 0.21 %/ppm along the diagonal directions. WSVD is therefore the optimal algorithm for lipid composition spectra with highest SNR uniformly across peaks, reducing acquisition by up to 70% in patients, enabling clinical applications.
Original languageEnglish
JournalScientific Reports
Publication statusAccepted/In press - 24 Aug 2020

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    Mallikourti, V., Cheung, S. M., Gagliardi, T., Senn, N., Masannat, Y., McGordlrick, T., Sharma, R., Heys, S. D., & He, J. (Accepted/In press). Phased-array combination of 2D MRS for lipid composition quantification in patients with breast cancer. Scientific Reports.