Phoenix dactylifera L. sap enhances wound healing in Wistar rats

Phytochemical and histological assessment

Raed Abdennabi, Sana Bardaa, Meriem Mehdi, Mostafa E. Rateb, Andrea Raab, Faizah N. Alenezi, Zouheir Sahnoun, Neji Gharsallah, Lassaad Belbahri

Research output: Contribution to journalArticle

9 Citations (Scopus)
5 Downloads (Pure)

Abstract

The sap of the date palm "Lagmi" is a clear liquid, rich in sugars and minerals, with a pleasant flavour. Folk remedies based on the use of "Lagmi" for wound healing are still practiced. However, no studies investigated the relevance of "Lagmi" for wound healing. Therefore, the aim of this study was to identify the in vivo healing properties of "lagmi" on mechanically wounded wistar rats. Injured rats were divided into three groups: a first group treated by "lagmi", a second reference group processed by CICAFLORA(®) and a third untreated control group. On the 12th day of the experiment, total healing in the first group was reached, while healing was incomplete in the other groups. The sap seems to accelerate cell proliferation and contribute to faster healing with a gain of more than 30% as compared to CICAFLORA(®). Chemical Analysis of "Lagmi" showed important radical scavenging activity and high total antioxidant capacity. Features reported to help healing process and/or provides a favourable environment for tissue healing in wound sites. Extensive characterization of "Lagmi" phenolic and flavonoid compounds by High Resolution LC-MS (LC-HRESIMS) analysis indicates "Lagmi" is an important source of known anti-inflammatory compounds as well as promising wound healing candidates.

Original languageEnglish
Pages (from-to)443-450
Number of pages8
JournalInternational journal of biological macromolecules
Volume88
Early online date8 Apr 2016
DOIs
Publication statusPublished - Jul 2016

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Phytochemicals
Wound Healing
Wistar Rats
Rats
Flavors
Scavenging
Cell proliferation
Flavonoids
Sugars
Minerals
Anti-Inflammatory Agents
Antioxidants
Tissue
Liquids
Traditional Medicine
Chemical analysis
Experiments
Cell Proliferation
Control Groups
Phoeniceae

Keywords

  • date palm sap
  • minerals
  • wound healing
  • LC–MS analysis
  • antioxydant
  • bioactive phenolic compounds

Cite this

Phoenix dactylifera L. sap enhances wound healing in Wistar rats : Phytochemical and histological assessment. / Abdennabi, Raed; Bardaa, Sana; Mehdi, Meriem; Rateb, Mostafa E.; Raab, Andrea; Alenezi, Faizah N.; Sahnoun, Zouheir; Gharsallah, Neji; Belbahri, Lassaad.

In: International journal of biological macromolecules, Vol. 88, 07.2016, p. 443-450.

Research output: Contribution to journalArticle

Abdennabi, Raed ; Bardaa, Sana ; Mehdi, Meriem ; Rateb, Mostafa E. ; Raab, Andrea ; Alenezi, Faizah N. ; Sahnoun, Zouheir ; Gharsallah, Neji ; Belbahri, Lassaad. / Phoenix dactylifera L. sap enhances wound healing in Wistar rats : Phytochemical and histological assessment. In: International journal of biological macromolecules. 2016 ; Vol. 88. pp. 443-450.
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author = "Raed Abdennabi and Sana Bardaa and Meriem Mehdi and Rateb, {Mostafa E.} and Andrea Raab and Alenezi, {Faizah N.} and Zouheir Sahnoun and Neji Gharsallah and Lassaad Belbahri",
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T2 - Phytochemical and histological assessment

AU - Abdennabi, Raed

AU - Bardaa, Sana

AU - Mehdi, Meriem

AU - Rateb, Mostafa E.

AU - Raab, Andrea

AU - Alenezi, Faizah N.

AU - Sahnoun, Zouheir

AU - Gharsallah, Neji

AU - Belbahri, Lassaad

N1 - Acknowledgment Financial support of the Tunisian Ministry of Higher Education and Scientific Research is gratefully acknowledged.

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N2 - The sap of the date palm "Lagmi" is a clear liquid, rich in sugars and minerals, with a pleasant flavour. Folk remedies based on the use of "Lagmi" for wound healing are still practiced. However, no studies investigated the relevance of "Lagmi" for wound healing. Therefore, the aim of this study was to identify the in vivo healing properties of "lagmi" on mechanically wounded wistar rats. Injured rats were divided into three groups: a first group treated by "lagmi", a second reference group processed by CICAFLORA(®) and a third untreated control group. On the 12th day of the experiment, total healing in the first group was reached, while healing was incomplete in the other groups. The sap seems to accelerate cell proliferation and contribute to faster healing with a gain of more than 30% as compared to CICAFLORA(®). Chemical Analysis of "Lagmi" showed important radical scavenging activity and high total antioxidant capacity. Features reported to help healing process and/or provides a favourable environment for tissue healing in wound sites. Extensive characterization of "Lagmi" phenolic and flavonoid compounds by High Resolution LC-MS (LC-HRESIMS) analysis indicates "Lagmi" is an important source of known anti-inflammatory compounds as well as promising wound healing candidates.

AB - The sap of the date palm "Lagmi" is a clear liquid, rich in sugars and minerals, with a pleasant flavour. Folk remedies based on the use of "Lagmi" for wound healing are still practiced. However, no studies investigated the relevance of "Lagmi" for wound healing. Therefore, the aim of this study was to identify the in vivo healing properties of "lagmi" on mechanically wounded wistar rats. Injured rats were divided into three groups: a first group treated by "lagmi", a second reference group processed by CICAFLORA(®) and a third untreated control group. On the 12th day of the experiment, total healing in the first group was reached, while healing was incomplete in the other groups. The sap seems to accelerate cell proliferation and contribute to faster healing with a gain of more than 30% as compared to CICAFLORA(®). Chemical Analysis of "Lagmi" showed important radical scavenging activity and high total antioxidant capacity. Features reported to help healing process and/or provides a favourable environment for tissue healing in wound sites. Extensive characterization of "Lagmi" phenolic and flavonoid compounds by High Resolution LC-MS (LC-HRESIMS) analysis indicates "Lagmi" is an important source of known anti-inflammatory compounds as well as promising wound healing candidates.

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KW - LC–MS analysis

KW - antioxydant

KW - bioactive phenolic compounds

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DO - 10.1016/j.ijbiomac.2016.04.015

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SN - 0141-8130

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