Phoenix dactylifera L. sap enhances wound healing in Wistar rats: Phytochemical and histological assessment

Raed Abdennabi; Sana Bardaa; Meriem Mehdi; Mostafa E. Rateb; Andrea Raab; Faizah N. Alenezi; Zouheir Sahnoun; Neji Gharsallah; Lassaad Belbahri

doi:10.1016/j.ijbiomac.2016.04.015

Phoenix dactylifera L. sap enhances wound healing in Wistar rats: Phytochemical and histological assessment

Raed Abdennabi, Sana Bardaa, Meriem Mehdi, Mostafa E. Rateb, Andrea Raab, Faizah N. Alenezi, Zouheir Sahnoun, Neji Gharsallah, Lassaad Belbahri

Chemistry

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21 Citations (Scopus)

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Abstract

The sap of the date palm "Lagmi" is a clear liquid, rich in sugars and minerals, with a pleasant flavour. Folk remedies based on the use of "Lagmi" for wound healing are still practiced. However, no studies investigated the relevance of "Lagmi" for wound healing. Therefore, the aim of this study was to identify the in vivo healing properties of "lagmi" on mechanically wounded wistar rats. Injured rats were divided into three groups: a first group treated by "lagmi", a second reference group processed by CICAFLORA(®) and a third untreated control group. On the 12th day of the experiment, total healing in the first group was reached, while healing was incomplete in the other groups. The sap seems to accelerate cell proliferation and contribute to faster healing with a gain of more than 30% as compared to CICAFLORA(®). Chemical Analysis of "Lagmi" showed important radical scavenging activity and high total antioxidant capacity. Features reported to help healing process and/or provides a favourable environment for tissue healing in wound sites. Extensive characterization of "Lagmi" phenolic and flavonoid compounds by High Resolution LC-MS (LC-HRESIMS) analysis indicates "Lagmi" is an important source of known anti-inflammatory compounds as well as promising wound healing candidates.

Original language	English
Pages (from-to)	443-450
Number of pages	8
Journal	International journal of biological macromolecules
Volume	88
Early online date	8 Apr 2016
DOIs	https://doi.org/10.1016/j.ijbiomac.2016.04.015
Publication status	Published - Jul 2016

Bibliographical note

Acknowledgment
Financial support of the Tunisian Ministry of Higher Education and Scientific Research is gratefully acknowledged.

Keywords

date palm sap
minerals
wound healing
LC–MS analysis
antioxydant
bioactive phenolic compounds

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© 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Accepted author manuscript, 1.21 MBLicence: CC BY-NC-ND

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title = "Phoenix dactylifera L. sap enhances wound healing in Wistar rats: Phytochemical and histological assessment",

abstract = "The sap of the date palm {"}Lagmi{"} is a clear liquid, rich in sugars and minerals, with a pleasant flavour. Folk remedies based on the use of {"}Lagmi{"} for wound healing are still practiced. However, no studies investigated the relevance of {"}Lagmi{"} for wound healing. Therefore, the aim of this study was to identify the in vivo healing properties of {"}lagmi{"} on mechanically wounded wistar rats. Injured rats were divided into three groups: a first group treated by {"}lagmi{"}, a second reference group processed by CICAFLORA({\textregistered}) and a third untreated control group. On the 12th day of the experiment, total healing in the first group was reached, while healing was incomplete in the other groups. The sap seems to accelerate cell proliferation and contribute to faster healing with a gain of more than 30% as compared to CICAFLORA({\textregistered}). Chemical Analysis of {"}Lagmi{"} showed important radical scavenging activity and high total antioxidant capacity. Features reported to help healing process and/or provides a favourable environment for tissue healing in wound sites. Extensive characterization of {"}Lagmi{"} phenolic and flavonoid compounds by High Resolution LC-MS (LC-HRESIMS) analysis indicates {"}Lagmi{"} is an important source of known anti-inflammatory compounds as well as promising wound healing candidates.",

keywords = "date palm sap, minerals, wound healing, LC–MS analysis, antioxydant, bioactive phenolic compounds",

author = "Raed Abdennabi and Sana Bardaa and Meriem Mehdi and Rateb, {Mostafa E.} and Andrea Raab and Alenezi, {Faizah N.} and Zouheir Sahnoun and Neji Gharsallah and Lassaad Belbahri",

note = "Acknowledgment Financial support of the Tunisian Ministry of Higher Education and Scientific Research is gratefully acknowledged.",

year = "2016",

month = jul,

doi = "10.1016/j.ijbiomac.2016.04.015",

language = "English",

volume = "88",

pages = "443--450",

journal = "International journal of biological macromolecules",

issn = "0141-8130",

publisher = "Elsevier",

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TY - JOUR

T1 - Phoenix dactylifera L. sap enhances wound healing in Wistar rats

T2 - Phytochemical and histological assessment

AU - Abdennabi, Raed

AU - Bardaa, Sana

AU - Mehdi, Meriem

AU - Rateb, Mostafa E.

AU - Raab, Andrea

AU - Alenezi, Faizah N.

AU - Sahnoun, Zouheir

AU - Gharsallah, Neji

AU - Belbahri, Lassaad

N1 - Acknowledgment Financial support of the Tunisian Ministry of Higher Education and Scientific Research is gratefully acknowledged.

PY - 2016/7

Y1 - 2016/7

N2 - The sap of the date palm "Lagmi" is a clear liquid, rich in sugars and minerals, with a pleasant flavour. Folk remedies based on the use of "Lagmi" for wound healing are still practiced. However, no studies investigated the relevance of "Lagmi" for wound healing. Therefore, the aim of this study was to identify the in vivo healing properties of "lagmi" on mechanically wounded wistar rats. Injured rats were divided into three groups: a first group treated by "lagmi", a second reference group processed by CICAFLORA(®) and a third untreated control group. On the 12th day of the experiment, total healing in the first group was reached, while healing was incomplete in the other groups. The sap seems to accelerate cell proliferation and contribute to faster healing with a gain of more than 30% as compared to CICAFLORA(®). Chemical Analysis of "Lagmi" showed important radical scavenging activity and high total antioxidant capacity. Features reported to help healing process and/or provides a favourable environment for tissue healing in wound sites. Extensive characterization of "Lagmi" phenolic and flavonoid compounds by High Resolution LC-MS (LC-HRESIMS) analysis indicates "Lagmi" is an important source of known anti-inflammatory compounds as well as promising wound healing candidates.

AB - The sap of the date palm "Lagmi" is a clear liquid, rich in sugars and minerals, with a pleasant flavour. Folk remedies based on the use of "Lagmi" for wound healing are still practiced. However, no studies investigated the relevance of "Lagmi" for wound healing. Therefore, the aim of this study was to identify the in vivo healing properties of "lagmi" on mechanically wounded wistar rats. Injured rats were divided into three groups: a first group treated by "lagmi", a second reference group processed by CICAFLORA(®) and a third untreated control group. On the 12th day of the experiment, total healing in the first group was reached, while healing was incomplete in the other groups. The sap seems to accelerate cell proliferation and contribute to faster healing with a gain of more than 30% as compared to CICAFLORA(®). Chemical Analysis of "Lagmi" showed important radical scavenging activity and high total antioxidant capacity. Features reported to help healing process and/or provides a favourable environment for tissue healing in wound sites. Extensive characterization of "Lagmi" phenolic and flavonoid compounds by High Resolution LC-MS (LC-HRESIMS) analysis indicates "Lagmi" is an important source of known anti-inflammatory compounds as well as promising wound healing candidates.

KW - date palm sap

KW - minerals

KW - wound healing

KW - LC–MS analysis

KW - antioxydant

KW - bioactive phenolic compounds

U2 - 10.1016/j.ijbiomac.2016.04.015

DO - 10.1016/j.ijbiomac.2016.04.015

M3 - Article

C2 - 27064088

SN - 0141-8130

VL - 88

SP - 443

EP - 450

JO - International journal of biological macromolecules

JF - International journal of biological macromolecules

ER -

Phoenix dactylifera L. sap enhances wound healing in Wistar rats: Phytochemical and histological assessment

Abstract

Bibliographical note

Keywords

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