Phoenix dactylifera L. sap enhances wound healing in Wistar rats: Phytochemical and histological assessment

Raed Abdennabi, Sana Bardaa, Meriem Mehdi, Mostafa E. Rateb, Andrea Raab, Faizah N. Alenezi, Zouheir Sahnoun, Neji Gharsallah, Lassaad Belbahri

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)
8 Downloads (Pure)


The sap of the date palm "Lagmi" is a clear liquid, rich in sugars and minerals, with a pleasant flavour. Folk remedies based on the use of "Lagmi" for wound healing are still practiced. However, no studies investigated the relevance of "Lagmi" for wound healing. Therefore, the aim of this study was to identify the in vivo healing properties of "lagmi" on mechanically wounded wistar rats. Injured rats were divided into three groups: a first group treated by "lagmi", a second reference group processed by CICAFLORA(®) and a third untreated control group. On the 12th day of the experiment, total healing in the first group was reached, while healing was incomplete in the other groups. The sap seems to accelerate cell proliferation and contribute to faster healing with a gain of more than 30% as compared to CICAFLORA(®). Chemical Analysis of "Lagmi" showed important radical scavenging activity and high total antioxidant capacity. Features reported to help healing process and/or provides a favourable environment for tissue healing in wound sites. Extensive characterization of "Lagmi" phenolic and flavonoid compounds by High Resolution LC-MS (LC-HRESIMS) analysis indicates "Lagmi" is an important source of known anti-inflammatory compounds as well as promising wound healing candidates.

Original languageEnglish
Pages (from-to)443-450
Number of pages8
JournalInternational journal of biological macromolecules
Early online date8 Apr 2016
Publication statusPublished - Jul 2016


  • date palm sap
  • minerals
  • wound healing
  • LC–MS analysis
  • antioxydant
  • bioactive phenolic compounds


Dive into the research topics of 'Phoenix dactylifera L. sap enhances wound healing in Wistar rats: Phytochemical and histological assessment'. Together they form a unique fingerprint.

Cite this