Phospholipid metabolites, prognosis and proliferation in human breast carcinoma

Timothy Andrew Davies Smith, C Bush, C Jamieson, Jenny Titley, Martin Leach, D Wilman, Ralph McReady

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

The content of the phospholipid metabolites, phosphocholine, phosphoethanolamine, glycerophosphorylcholine and glycerophosphorylethanolamine was measured in chemical extracts from 46 human breast carcinoma using 31P NMR spectroscopy. Some patients had received therapy prior to tumour resection. The data were therefore stratified into two groups: (i) all tumours; and (ii) untreated tumours. Three indices of tumour proliferation i.e., mitotic index, Ki67 and S-phase fraction were determined on tissue from the same tumours and were found not to correlate with the content of any of these metabolites. In addition oestrogen-receptor status and density, tumour grade and DNA ploidy were obtained on some tumours. The phosphocholine content was higher in high grade tumours when compared with low grade tumours. There was no apparent relationship between DNA ploidy and the content of any of these metabolites. Glycerophosphorylcholine content of oestrogen-receptor positive tumours correlated with receptor density. However, there was no significant difference between receptor positive and negative tumours in the content of any of the phospholipid metabolites measured.
Original languageEnglish
Pages (from-to)318-323
Number of pages6
JournalNMR in Biomedicine
Volume6
Issue number5
Publication statusPublished - 1993

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Metabolites
Tumors
Phospholipids
Breast Neoplasms
Neoplasms
Glycerylphosphorylcholine
Phosphorylcholine
Ploidies
Estrogen Receptors
Mitotic Index
DNA
S Phase
Nuclear magnetic resonance spectroscopy
Magnetic Resonance Spectroscopy
Tissue

Cite this

Smith, T. A. D., Bush, C., Jamieson, C., Titley, J., Leach, M., Wilman, D., & McReady, R. (1993). Phospholipid metabolites, prognosis and proliferation in human breast carcinoma. NMR in Biomedicine, 6(5), 318-323.

Phospholipid metabolites, prognosis and proliferation in human breast carcinoma. / Smith, Timothy Andrew Davies; Bush, C; Jamieson, C; Titley, Jenny; Leach, Martin ; Wilman, D; McReady, Ralph.

In: NMR in Biomedicine, Vol. 6, No. 5, 1993, p. 318-323.

Research output: Contribution to journalArticle

Smith, TAD, Bush, C, Jamieson, C, Titley, J, Leach, M, Wilman, D & McReady, R 1993, 'Phospholipid metabolites, prognosis and proliferation in human breast carcinoma', NMR in Biomedicine, vol. 6, no. 5, pp. 318-323.
Smith TAD, Bush C, Jamieson C, Titley J, Leach M, Wilman D et al. Phospholipid metabolites, prognosis and proliferation in human breast carcinoma. NMR in Biomedicine. 1993;6(5):318-323.
Smith, Timothy Andrew Davies ; Bush, C ; Jamieson, C ; Titley, Jenny ; Leach, Martin ; Wilman, D ; McReady, Ralph. / Phospholipid metabolites, prognosis and proliferation in human breast carcinoma. In: NMR in Biomedicine. 1993 ; Vol. 6, No. 5. pp. 318-323.
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AB - The content of the phospholipid metabolites, phosphocholine, phosphoethanolamine, glycerophosphorylcholine and glycerophosphorylethanolamine was measured in chemical extracts from 46 human breast carcinoma using 31P NMR spectroscopy. Some patients had received therapy prior to tumour resection. The data were therefore stratified into two groups: (i) all tumours; and (ii) untreated tumours. Three indices of tumour proliferation i.e., mitotic index, Ki67 and S-phase fraction were determined on tissue from the same tumours and were found not to correlate with the content of any of these metabolites. In addition oestrogen-receptor status and density, tumour grade and DNA ploidy were obtained on some tumours. The phosphocholine content was higher in high grade tumours when compared with low grade tumours. There was no apparent relationship between DNA ploidy and the content of any of these metabolites. Glycerophosphorylcholine content of oestrogen-receptor positive tumours correlated with receptor density. However, there was no significant difference between receptor positive and negative tumours in the content of any of the phospholipid metabolites measured.

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